Hemolytic Anemia and Metabolic Acidosis: Think about Glutathione Synthetase Deficiency

2014 ◽  
Vol 34 (1) ◽  
pp. 18-20 ◽  
Author(s):  
Salma Ben Ameur ◽  
Hajer Aloulou ◽  
Fehmi Nasrallah ◽  
Thouraya Kamoun ◽  
Naziha Kaabachi ◽  
...  
Blood ◽  
1983 ◽  
Vol 62 (4) ◽  
pp. 754-757 ◽  
Author(s):  
JT Prchal ◽  
WM Crist ◽  
M Roper ◽  
VP Wellner

Abstract The clinical and laboratory features of a 3-mo-old black male infant with glutathione (GSH) synthetase deficiency of the generalized type was evaluated. Partial albinism, brisk hemolytic anemia, recurrent febrile episodes, and mental retardation were noted. Also, severe recurrent metabolic acidosis and marked oxoprolinemia and oxoprolinuria were found in the proband but not in his first-degree relatives. The relationship of these disease manifestations to the underlying metabolic defect is discussed.


Blood ◽  
1983 ◽  
Vol 62 (4) ◽  
pp. 754-757
Author(s):  
JT Prchal ◽  
WM Crist ◽  
M Roper ◽  
VP Wellner

The clinical and laboratory features of a 3-mo-old black male infant with glutathione (GSH) synthetase deficiency of the generalized type was evaluated. Partial albinism, brisk hemolytic anemia, recurrent febrile episodes, and mental retardation were noted. Also, severe recurrent metabolic acidosis and marked oxoprolinemia and oxoprolinuria were found in the proband but not in his first-degree relatives. The relationship of these disease manifestations to the underlying metabolic defect is discussed.


1989 ◽  
Vol 35 (4) ◽  
pp. 684-686 ◽  
Author(s):  
M H Creer ◽  
B W Lau ◽  
J D Jones ◽  
K M Chan

Abstract Pyroglutamic acidemia, a rare metabolic disorder, usually appears in infancy. It is characterized by retardation, ataxia, hemolytic anemia, and chronic acidosis and is caused by a marked deficiency of glutathione synthetase (EC 6.3.2.3) activity. This disease is inherited as an autosomal recessive trait, but the clinical condition is also detected in heterozygotes. We report an unusual case of high-anion-gap metabolic acidosis in a 52-year-old woman who was admitted with neurological complaints and breathing problems but without the characteristic clinical features of congenital glutathione synthetase deficiency. The etiology of the acidosis could not be attributed to ketoacidosis, lactic acidosis, or ingestion of methanol, salicylate, or ethylene glycol. Analysis of the patient's plasma and urine for organic acids revealed the presence of high concentrations of pyroglutamate (5-oxoproline), which remained high throughout her hospitalization.


PEDIATRICS ◽  
2016 ◽  
Vol 138 (3) ◽  
pp. e20154324-e20154324 ◽  
Author(s):  
I. Signolet ◽  
R. Chenouard ◽  
F. Oca ◽  
M. Barth ◽  
P. Reynier ◽  
...  

Author(s):  
David J. Timson ◽  
Richard J. Reece ◽  
James B. Thoden ◽  
Hazel M. Holden ◽  
Andrea L. Utz ◽  
...  

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