Non-targeted screening for novel psychoactive substances among agitated emergency department patients

2016 ◽  
Vol 54 (4) ◽  
pp. 319-323 ◽  
Author(s):  
Derrick Lung ◽  
Nathan Wilson ◽  
Francois-Thibaut Chatenet ◽  
Clemence LaCroix ◽  
Roy Gerona
Keyword(s):  
Emergency Department ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Targeted Screening ◽  
Emergency Department Patients

Fifteen-minute consultation: Recognition and management of the child or young person who has ingested a novel psychoactive substance

2020 ◽  
Vol 105 (6) ◽  
pp. 336-341
Author(s):  
Lee Tubman ◽  
Niall Mullen ◽  
Derek K Tracy
Keyword(s):  
Emergency Department ◽  
Legal Status ◽  
Young Person ◽  
Clinical Effects ◽  
Acute Management ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Children And Young People ◽  
Functional Classes

Intoxicated children and young people (CYP) attending the paediatric emergency department (PED) are typically under the influence of alcohol or established recreational agents such as cannabis or ecstasy. The last decade or so has seen an increase in the numbers of CYP in PED who have used novel psychoactive substances (NPS). In this review, we describe four different functional classes of NPS, their legal status, clinical effects, acute management and interventions to reduce harm.

scholarly journals The potential for complementary targeted/non-targeted screening of novel psychoactive substances in equine urine using liquid chromatography-high resolution accurate mass spectrometry

2016 ◽  
Vol 8 (8) ◽  
pp. 1789-1797 ◽  
Author(s):  
Adam Cawley ◽  
Daniel Pasin ◽  
Namuun Ganbat ◽  
Laura Ennis ◽  
Corrine Smart ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Forensic Toxicology ◽  
Accurate Mass ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Targeted Screening ◽  
Accurate Mass Spectrometry ◽  
High Resolution Accurate Mass

The use of LC-HRAM spectrometry to identify ‘unknown’ compounds by non-targeted screening provides a potential advantage for forensic toxicology.

A prospective observational study of emergency department presentations following novel psychoactive substance use

2018 ◽  
Vol 63 (2) ◽  
pp. 39-44 ◽  
Author(s):  
David E Henshall ◽  
Callum WD Innes ◽  
Scott R Morrison ◽  
Blair Wilson ◽  
Ryan A Brown ◽  
...  
Keyword(s):  
Emergency Department ◽  
Drug Use ◽  
Illicit Drugs ◽  
Behavioural Change ◽  
Population Characteristics ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Unique Challenge ◽  
Patient Demographics ◽  
History Of

Background and aims Novel psychoactive substances are compounds intended to mimic the effects of illicit drugs. They provide a unique challenge to healthcare, as complications of their use and their impact on services are relatively unknown. This study aims to determine nature of presentations, patient demographics and impact on healthcare. Methods Novel psychoactive substances users who presented to a large urban emergency department over 4 weeks were prospectively identified and followed for 1 year. Patients over 13 years old were eligible for inclusion. Information regarding patient demographics and presentations was collected. Results During the study period, 53 patients (39 male), mean age 32.6 ± 8.9 (±standard deviation), presented 148 times with complaints relating to novel psychoactive substances use. Study population characteristics included history of illicit drug use (83.0%), intravenous drug use (64.2%), psychiatric diagnosis or symptoms (56.6%), methadone prescription (52.8%) and having no fixed abode (37.7%). Injection was the most common method of use (72.3%), Burst the most commonly named agent (19.6%) and behavioural change the most common presenting complaint (31.1%). Patients collectively spent 10,620 h in hospital over 1 year. Conclusion This study highlights differences between the young population targeted by government campaigns regarding novel psychoactive substances use and the presenting population to hospital, and the associated burden on the National Health Service.

Prospettiva e Valore della matrice Cheratinica nella valutazione dell'utilizzo di Nuove Sostanze Psicoattive nella popolazione che afferisce ai SERD

MISSION ◽  
2020 ◽  
pp. 39-44
Author(s):  
Concettina Varango ◽  
Francesca Musarella ◽  
Mara Cella ◽  
Antonella Varango
Keyword(s):  
Novel Psychoactive Substances ◽  
Psychoactive Substances

Questo articolo nasce dall'esigenza di informare un più ampio pubblico sul pericolo rappresentato da queste sostanze, far conoscere le NPS (Novel Psychoactive substances) agli operatori del settore (personale di laboratorio, personale delle unità di emergenza/ urgenza, operatori sanitari, ricercatori, ecc.) al fine di agevolare l'analisi di campioni sconosciuti e divulgare i dati scientifici che cominciano ad emergere da studi clinici e preclinici sui loro effetti tossici e farmacologici. Dal 2009 sono comparsi nel gruppo delle N.P.S., i nuovi oppioidi sintetici, molecole estremamente potenti che comportano una seria minaccia per la salute pubblica. Si tratta di prodotti dalla notevole potenza (il fentanyl, per esempio, capostipite di questa famiglia, ha un'azione circa 100 volte maggiore rispetto a quella della morfina) che vengono utilizzati sia per sé sia come adulteranti di partite di sostanze classiche, soprattutto eroina, causando scie di decessi per overdose. 

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