Measures of neurologic impairment and disability in multiple sclerosis

2019 ◽  
pp. 51-65
Keyword(s):  
Multiple Sclerosis ◽  
Neurologic Impairment

scholarly journals Self-Assessment of Neurologic Impairment in Multiple Sclerosis

1997 ◽  
Vol 11 (4) ◽  
pp. 207-211 ◽  
Author(s):  
P. K. Ratzker ◽  
J. M. Feldman ◽  
L. C. Scheinberg ◽  
N. G. LaRocca ◽  
C. R. Smith ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Self Assessment ◽  
Neurologic Impairment

Observer Disagreement in Rating Neurologic Impairment in Multiple Sclerosis: Facts and Consequences

1991 ◽  
Vol 31 (2) ◽  
pp. 117-119 ◽  
Author(s):  
M.H. Verdier-Taillefer ◽  
M. Zuber ◽  
O. Lyon-Caen ◽  
M. Clanet ◽  
O. Gout ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurologic Impairment ◽  
Observer Disagreement

The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study

2002 ◽  
Vol 8 (6) ◽  
pp. 532-533 ◽  
Author(s):  
N F Kalkers ◽  
F Barkhof ◽  
E Bergers ◽  
R van Schijndel ◽  
C H Polman
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Brain Lesions ◽  
Cervical Cord ◽  
Primary Progressive Multiple Sclerosis ◽  
Resonance Imaging ◽  
Neuroprotective Agent ◽  
Primary Progressive ◽  
Neurologic Impairment ◽  
Versus Treatment

Progressive axonal loss is the most likely pathologic correlate of irreversible neurologic impairment in primary progressive multiple sclerosis. In a run-in versus treatment trial, we show that the neuroprotective agent riluzole seems to reduce the rate of cervical cord atrophy and the development of hypointense T1 brain lesions on magnetic resonance imaging.

scholarly journals Factors Associated with Health-Related Quality of Life Among Older People with Multiple Sclerosis

2014 ◽  
Vol 16 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Marijean Buhse ◽  
Wendy M. Banker ◽  
Lynn M. Clement
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Physical Disability ◽  
Health Related Quality ◽  
Neurologic Impairment ◽  
Related Quality ◽  
Health Related ◽  
Mental Hrqol ◽  
Physical Hrqol

Background: This study was conducted to determine which factors (clinical and demographic) are associated with mental and physical health-related quality of life (HRQOL) among people with multiple sclerosis (MS) aged 60 years and older. Methods: Data were collected at four MS centers on Long Island, New York, from a total of 211 patients. Three surveys were administered that collected demographic information and included validated questionnaires measuring quality of life (QOL), cognition, depression, and disability. Multivariate linear regression analyses examined the relationship between patient demographics and scores on standardized scales measuring mental and physical HRQOL (Multiple Sclerosis Quality of Life–54). Variables included in the regression models were selected on the basis of the Andersen Healthcare Utilization model. This framework encompasses the multiple influences on health status, including predisposing characteristics, enabling resources, need, and health behavior. Results: We found that mental HRQOL was negatively associated with having a high school education or less, risk of neurologic impairment, physical disability, and depression. No variables were positively associated with mental HRQOL. Physical HRQOL was negatively associated with risk of neurologic impairment, physical disability, depression, and the comorbidity of thyroid disease. However, patient employment and, surprisingly, being widowed were positively associated with physical HRQOL. These findings are consistent with those of similar studies among younger patients in which lower HRQOL was associated with increased disability, depression, risk of neurologic impairment, and lower levels of education. Conclusions: The findings that patient employment and being widowed were associated with better physical HRQOL suggest that older patients have the ability to adapt and adjust to the challenges of MS over time. Clinicians should regularly screen for HRQOL in older patients with MS.

Depression, coping and level of neurological impairment in multiple sclerosis

1997 ◽  
Vol 3 (4) ◽  
pp. 254-258 ◽  
Author(s):  
David C Mohr ◽  
Donald E Goodkin ◽  
Nicole Gatto ◽  
Judy Van Der Wende
Keyword(s):  
Multiple Sclerosis ◽  
Problem Solving ◽  
Neurological Impairment ◽  
Coping Behaviors ◽  
Neurologic Impairment ◽  
Cognitive Reframing ◽  
Disability Status ◽  
Multiple Sclerosis Patients ◽  
The Relationship ◽  
Different Levels

This study examined the relationship between coping and depression in multiple sclerosis patients, and how that relationship varies at different levels of physical impairment One-hundred and one patients with clinically definite MS were assessed using the Kurtzke Expanded Disability Status Scale (EDSS), the Ways of Coping Inventory (WCI) with three sub-scales developed by Wineman et al,25 and the Beck Depression Inventory (BDI). Depression was significantly higher at more advanced levels of neurologic impairment than at lower levels. Escape-Avoidance and Emotional Respite were positively related to level of depression. Planful Problem-Solving and Cognitive Reframing were negatively related to depression. An interaction between coping, depression, and level of neurologic impairment was observed in which Planful Problem-Solving and Cognitive Reframing were more strongly related to depression at higher levels of impairment The interaction effect for Escape-Avoidance and Emotional Respite with depression and level of impairment did not reach significance. It was concluded that there is a significant interaction between level of neurologic impairment, coping behaviors, and depression in patients with MS.

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