hnRNP U is differentially expressed in whole blood from patients with sepsis.

Hnrnp U ◽

Significant Gene ◽

Nuclear Ribonucleoprotein ◽

We probed published and public microarray datasets (1, 2) to discover the most significant gene expression changes in the blood of patients with sepsis. We identified significant differential expression of the heterogenous nuclear ribonucleoprotein hnRNP U in whole blood from patients with sepsis.

HNMT is differentially expressed in monocytes from patients with sepsis.

10.31219/osf.io/mztg2 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Differential Expression ◽

Whole Blood ◽

Blood Cells ◽

Significant Gene ◽

We probed published and public microarray datasets (1, 2) to discover the most significant gene expression changes in the blood and blood cells of patients with sepsis. We identified significant differential expression of the histamine N-methyltransferase HNMT in monocytes and whole blood from patients with sepsis.

The interleukin-18 receptor is differentially expressed in the blood during sepsis.

10.31219/osf.io/wved6 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Whole Blood ◽

Interleukin 18 ◽

Genes Encoding ◽

Significant Gene ◽

We probed published and public microarray datasets (1, 2) to discover the most significant gene expression changes in the blood of patients with sepsis. We found significant induction expression of IL18RAP and IL18R1, genes encoding subunits of the interleukin-18 receptor, in whole blood from patients with sepsis.

Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

10.31219/osf.io/6qphv ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Tissue Analysis ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dCTP pyrophosphatase 1, DCTPP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCTPP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DCTPP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCTPP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer. DCTPP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of TUFT1 in cancers of the breast.

10.31219/osf.io/3rk7f ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of KIF11 in cancers of the breast.

10.31219/osf.io/xh2ng ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the kinesin family member 11, KIF11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIF11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIF11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIF11 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. KIF11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

ERp29 is differentially expressed in the brains of patients with schizophrenia.

10.31219/osf.io/76vyd ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Frontal Cortex ◽

Differential Expression ◽

Schizoaffective Disorder ◽

Psychotic Disorders ◽

Auditory Hallucinations ◽

Gene Encoding ◽

Microarray Datasets ◽

Cardinal Feature

Visual and auditory hallucinations are a cardinal feature of psychotic disorders (1). We mined published and public microarray datasets (2, 3) to discover differentially expressed genes in schizophrenia and schizoaffective disorder. We found significant differential expression of the gene encoding ERp29 in neurons of the dorsolateral pre-frontal cortex from patients with schizophrenia and schizoaffective disorder.

Differential expression of hematological and neurological expressed 1 in cancers of the breast.

10.31219/osf.io/y9xjm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the hematological and neurological expressed 1, HN1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HN1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HN1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HN1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer. HN1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

NDUFA13/YJEFN3 is differentially expressed in the brains of patients with schizophrenia.

10.31219/osf.io/r6uyd ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Frontal Cortex ◽

Differential Expression ◽

Differentially Expressed Genes ◽

Schizoaffective Disorder ◽

Psychotic Disorders ◽

Auditory Hallucinations ◽

Microarray Datasets ◽

Cardinal Feature

Visual and auditory hallucinations are a cardinal feature of psychotic disorders (1). We mined published and public microarray datasets (2, 3) to discover differentially expressed genes in schizophrenia and schizoaffective disorder. We found significant differential expression of transcripts overlapping NDUFA13 and YJEFN3 genes in neurons of the dorsolateral pre-frontal cortex from patients with schizophrenia and schizoaffective disorder.

A pseudogene of Brd7, Brd7p3 is differentially expressed in the brains of patients with schizophrenia.

10.31219/osf.io/68at7 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Frontal Cortex ◽

Differential Expression ◽

Differentially Expressed Genes ◽

Schizoaffective Disorder ◽

Psychotic Disorders ◽

Auditory Hallucinations ◽

Microarray Datasets ◽

Cardinal Feature

Visual and auditory hallucinations are a cardinal feature of psychotic disorders (1). We mined published and public microarray datasets (2, 3) to discover differentially expressed genes in schizophrenia and schizoaffective disorder. We found significant differential expression of pseudogene 3 of the bromodomain containing 7 molecule, Brd7p3, in neurons of the dorsolateral pre-frontal cortex from patients with schizophrenia and schizoaffective disorder.

Differential expression of NACC1 in cancers of the breast.

10.31219/osf.io/gbk9w ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Luminal B ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding nucleus accumbens associated 1, NACC1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NACC1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. NACC1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NACC1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer. NACC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.