CBX7 is differentially expressed in high-grade serous ovarian cancers.

Global Gene Expression ◽

Ovarian Tumors ◽

High Grade ◽

Normal Ovary ◽

Primary Tumors ◽

Ovarian cancer is the most lethal gynecologic cancer (1). To identify genes associated with high-grade serous ovarian cancer (HGSC), we used published microarray data (2, 3) to compare global gene expression profiles of the normal ovary with that of primary tumors from women diagnosed with HGSC. We identified caspase-12 (CASP12) (4) as among the genes whose expression was most quantitatively different in HGSC ovarian tumors. CASP12 expression was decreased in ovarian tumors when compared to normal ovary. These data indicate that CASP12 might be relevant to the biology of high-grade serous ovarian cancers.

Open reading frame 28 on Chromosome 14 (C14ORF28) is differentially expressed in high-grade serous ovarian cancers.

10.31219/osf.io/t54mb ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Global Gene Expression ◽

Ovarian Tumors ◽

High Grade ◽

Normal Ovary ◽

Primary Tumors ◽

Ovarian cancer is the most lethal gynecologic cancer (1-3). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (4, 5). We identified C14ORF28 (6, 7) as among the genes whose expression was most different in HGSC ovarian tumors. C14ORF28 expression was significantly lower in ovarian tumors relative to normal ovary. These data indicate that expression of C14ORF28 might be perturbed in high-grade serous ovarian cancers.

PEG3 is differentially expressed in high-grade serous ovarian cancers.

10.31219/osf.io/962ha ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Ovarian Tumors ◽

Differentially Expressed ◽

High Grade ◽

Normal Ovary ◽

Primary Tumors ◽

Ovarian cancer is the most lethal gynecologic cancer (1-3). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (4, 5). We identified paternally expressed gene 3 (PEG3) (6) as among the genes whose expression was most different in HGSC ovarian tumors. PEG3 expression was significantly lower in ovarian tumors relative to normal ovary. In one dataset, an anti-sense transcript produced at the PEG3 locus was among those most differentially expressed between HGSC tumors and benign ovarial tissue. These data indicate that significant changes in expression at the PEG3 imprinted locus could be a feature of high-grade serous ovarian cancers.

The forkhead box L2 transcription factor (FOXL2) is differentially expressed in high-grade serous ovarian cancers.

10.31219/osf.io/8nt6v ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Ovarian Cancer ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Ovarian Tumors ◽

High Grade ◽

Normal Ovary ◽

Primary Tumors ◽

Forkhead Box ◽

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We identified the forkhead box L2, (FOXL2) (4) as among the genes whose expression was most different in HGSC ovarian tumors. FOXL2 expression was significantly lower in ovarian tumors relative to normal ovary. FOXL2 has established roles in ovarian development (4, 5), and the FOXL2 gene is mutated in granulosa-cell tumors of the ovary (6). These data indicate FOXL2 might also be perturbed, at the level of gene expression, in high-grade serous ovarian cancers.

Differential expression of cyclin B2 in human epithelial ovarian cancer.

10.31219/osf.io/935em ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Fallopian Tube ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Global Gene Expression ◽

High Grade ◽

Primary Tumors ◽

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding cyclin B2, CCNB2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CCNB2 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. These data indicate that expression of CCNB2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CCNB2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

Multiple members of the transcription factor elongation A like (TCEAL) family are differentially expressed in high-grade serous ovarian cancers.

10.31219/osf.io/m9fsw ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Microarray Data ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Global Gene Expression ◽

High Grade ◽

Significant Differential Expression ◽

Primary Tumors ◽

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). Perturbed expression of TCEAL7 has previously been reported in epithelial ovarian cancers (4). Here we find significant differential expression of multiple members of the TCEAL gene family in high-grade serous ovarian tumors.

Carboxypeptidase Z is differentially expressed in high-grade serous ovarian cancers.

10.31219/osf.io/7me3r ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Microarray Data ◽

Expression Profiles ◽

Global Gene Expression ◽

Ovarian Tumors ◽

High Grade ◽

Normal Ovary ◽

Serous Ovarian Cancer ◽

Primary Tumors ◽

We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (1, 2). We identified carboxypeptidase Z (CPZ) (3) as among the genes whose expression was most different in HGSC ovarian tumors. CPZ expression was significantly lower in ovarian tumors relative to normal ovary. CPZ may be relevant to the biology of high-grade serous ovarian cancers.

Differential expression of tropomyosin 3 in human epithelial ovarian cancer.

10.31219/osf.io/xp359 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Fallopian Tube ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Global Gene Expression ◽

High Grade ◽

Primary Tumors ◽

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding tropomyosin 3, TPM3, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. TPM3 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. TPM3 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of TPM3 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. TPM3 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

Differential expression of coronin 6 in human epithelial ovarian cancer.

10.31219/osf.io/va2u6 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Fallopian Tube ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Global Gene Expression ◽

High Grade ◽

Primary Tumors ◽

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding coronin 6, CORO6, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CORO6 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. CORO6 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of CORO6 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CORO6 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

BIRC5 is differentially expressed in epithelial ovarian cancer.

10.31219/osf.io/t5jmg ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Ovarian Cancer ◽

Cancer Progression ◽

Expression Profiles ◽

Gynecologic Cancer ◽

Ovarian Tumors ◽

Normal Ovary ◽

Primary Tumors ◽

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We sought to identify genes associated with epithelial ovarian cancer and the high-grade serous ovarian cancer (HGSC) subtype by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with epithelial cancer and HGSC in specific using published microarray data (2, 3). We identified the gene encoding the baculoviral inhibitor of apoptosis repeat (IAP) containing 5, BIRC5 as among the genes whose expression was most different in epithelial ovarian cancer and in HGSC ovarian tumors. BIRC5 expression was significantly higher in ovarian tumors relative to normal ovary. Correlation of BIRC5 expression with survival outcomes in patients with ovarian cancer was complex, with low expression favorable early in disease and high expression favorable later in disease. These data indicate that expression of BIRC5 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. BIRC5 may be relevant to pathways underlying ovarian cancer progression.