Open reading frame 28 on Chromosome 14 (C14ORF28) is differentially expressed in high-grade serous ovarian cancers.
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Ovarian cancer is the most lethal gynecologic cancer (1-3). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (4, 5). We identified C14ORF28 (6, 7) as among the genes whose expression was most different in HGSC ovarian tumors. C14ORF28 expression was significantly lower in ovarian tumors relative to normal ovary. These data indicate that expression of C14ORF28 might be perturbed in high-grade serous ovarian cancers.
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