Expression of T-cell receptor gamma, delta, and alpha gene segments associates with survival in triple negative breast cancer.
Keyword(s):
We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer (TNBC) patients based on survival at time of analysis: dead or alive. TRAJ27, TRDC, TRDJ1, and TRGV1 emerged as among the most differentially expressed genes, transcriptome-wide, when comparing the primary tumors of triple negative breast cancer patients dead or alive. TRAJ27, TRDC, TRDJ1, and TRGV1 were all present at significantly higher quantities in the tumors of TNBC patients alive. Differential expression of TCR genes TRAJ27, TRDC, TRDJ1, and TRGV1 may be of relevance in understanding the etiology or progression of triple negative breast cancer.
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