Differential expression of fibronectin in cancers of the breast.

Primary Tumors ◽

Tumor Expression ◽

Microarray Datasets ◽

Cd34 Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of CD34 when comparing primary tumors of the breast to the tissue of origin, the normal breast. CD34 expression in primary tumors of the breast was significantly lower than in normal breast tissue, and relapse-free and overall survival in breast cancer patients was significantly worse CD34 patients with low tumor expression of CD34 than in patients with high tumor expression of CD34. CD34 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the Wolf-Hirschhorn syndrome candidate 1, WHSC1 (NSD2/KMT3G), in cancers of the breast.

10.31219/osf.io/x5ek8 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Normal Breast ◽

Breast Cancer Patients ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Tumor Expression ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the H3K36 methyltransferase Wolf-Hirschhorn syndrome candidate 1, WHSC1, also known as Nsd2 or KMT3G, when comparing primary tumors of the breast to the tissue of origin, the normal breast. WHSC1 expression in primary tumors of the breast was significantly higher than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly worse in patients with high tumor expression of WHSC1 than in patients with low tumor expression of WHSC1. WHSC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the oxytocin receptor, OXTR, in cancers of the breast.

10.31219/osf.io/wc7kb ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Oxytocin Receptor ◽

Normal Breast ◽

Breast Cancer Patients ◽

Gene Encoding ◽

Primary Tumors ◽

Tumor Expression ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2 , 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the oxytocin receptor, OXTR, when comparing primary tumors of the breast to the tissue of origin, the normal breast. OXTR expression in primary tumors of the breast was significantly lower than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly longer in patients with high tumor expression of OXTR than in patients with low tumor expression of OXTR. OXTR may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the DREAM MuvB core complex component Lin37 in cancers of the breast.

10.31219/osf.io/p7bfw ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Normal Breast ◽

Core Complex ◽

Relapse Free Survival ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the MuvB core complex and DREAM component Lin37 when comparing primary tumors of the breast to the tissue of origin, the normal breast. Expression of Lin37 in primary tumors of the breast was significantly higher than in normal breast tissue, and patients with low expression of Lin37 in primary tumors had greater relapse-free survival. Lin37 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the integrator complex subunit 7 in cancers of the breast.

10.31219/osf.io/zkftb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the integrator complex subunit 7, INTS7, when comparing primary tumors of the breast to the tissue of origin, the normal breast. INTS7 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of INTS7 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal A and HER2+ type cancers, but contrarily. INTS7 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of plexin A3 in cancers of the breast.

10.31219/osf.io/qxa6r ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Tissue Analysis ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding plexin A3, PLXNA3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PLXNA3 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PLXNA3 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ type cancer. PLXNA3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of topoisomerase IIα in cancers of the breast.

10.31219/osf.io/udgz2 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Normal Breast ◽

Topoisomerase Iiα ◽

Gene Encoding ◽

Dna Topoisomerase ◽

Primary Tumors ◽

Free Survival ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We identified significant differential expression of the gene encoding the DNA topoisomerase IIα, TOP2A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. Expression of TOP2A in primary tumors of the breast was significantly higher than in normal breast tissue, and patients with low expression of TOP2A in primary tumors had markedly superior overall and relapse-free survival. TOP2A may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the recombination activating gene 1 activating protein 1 in cancers of the breast.

10.31219/osf.io/g8qjp ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Recombination Activating Gene ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the recombination activating gene 1 activating protein 1, RAG1AP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. RAG1AP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of RAG1AP1 in primary tumors of the breast was correlated with recurrence-free survival in patients with basal type cancer. RAG1AP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression, coding and non-coding, of FGF14 in cancers of the breast.

10.31219/osf.io/em5g6 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Differentially Expressed ◽

Primary Tumors ◽

Tumor Expression ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of an antisense RNA transcribed from the FGF14 locus, FGF14-AS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. A coding FGF14 transcript was differentially expressed in the tumor cells of patients with triple negative breast cancer. FGF14-AS2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FGF14-AS2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed antisense transcript and patient survival outcomes influenced by PAM50 molecular subtype. FGF14-AS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of spermatogenesis associated serine rich 2 in cancers of the breast.

10.31219/osf.io/q6wvb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Microarray Datasets ◽

Basal Type

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding spermatogenesis associated serine rich 2, SPATS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SPATS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SPATS2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal type cancer. SPATS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.