scholarly journals Differential expression of CD34 in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Breast Tissue ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression ◽  
Microarray Datasets ◽  
Cd34 Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of CD34 when comparing primary tumors of the breast to the tissue of origin, the normal breast. CD34 expression in primary tumors of the breast was significantly lower than in normal breast tissue, and relapse-free and overall survival in breast cancer patients was significantly worse CD34 patients with low tumor expression of CD34 than in patients with high tumor expression of CD34. CD34 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of fibronectin in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Breast Tissue ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of fibronectin, encoded by FN1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FN1 expression in primary tumors of the breast was significantly higher than in normal breast tissue, and distant metastasis-free survival in breast cancer patients was significantly worse in patients with high tumor expression of FN1 than in patients with low tumor expression of FN1. FN1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the oxytocin receptor, OXTR, in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Oxytocin Receptor ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2 , 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the oxytocin receptor, OXTR, when comparing primary tumors of the breast to the tissue of origin, the normal breast. OXTR expression in primary tumors of the breast was significantly lower than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly longer in patients with high tumor expression of OXTR than in patients with low tumor expression of OXTR. OXTR may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the Wolf-Hirschhorn syndrome candidate 1, WHSC1 (NSD2/KMT3G), in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the H3K36 methyltransferase Wolf-Hirschhorn syndrome candidate 1, WHSC1, also known as Nsd2 or KMT3G, when comparing primary tumors of the breast to the tissue of origin, the normal breast. WHSC1 expression in primary tumors of the breast was significantly higher than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly worse in patients with high tumor expression of WHSC1 than in patients with low tumor expression of WHSC1. WHSC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression, coding and non-coding, of FGF14 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of an antisense RNA transcribed from the FGF14 locus, FGF14-AS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. A coding FGF14 transcript was differentially expressed in the tumor cells of patients with triple negative breast cancer. FGF14-AS2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FGF14-AS2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed antisense transcript and patient survival outcomes influenced by PAM50 molecular subtype. FGF14-AS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Tissue Analysis ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dCTP pyrophosphatase 1, DCTPP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCTPP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DCTPP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCTPP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer. DCTPP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of TUFT1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of KIF11 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the kinesin family member 11, KIF11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIF11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIF11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIF11 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. KIF11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of FXYD1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Normal Breast ◽  
Luminal A ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding FXYD domain containing ion transport regulator 1, FXYD1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FXYD1 mRNA was present at significantly reduced quantity in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FXYD1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. FXYD1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of phosphodiesterase 7B in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 7B, PDE7B, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE7B mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE7B in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE7B may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the DREAM MuvB core complex component Lin37 in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Normal Breast ◽  
Core Complex ◽  
Relapse Free Survival ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Free Survival ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the MuvB core complex and DREAM component Lin37 when comparing primary tumors of the breast to the tissue of origin, the normal breast. Expression of Lin37 in primary tumors of the breast was significantly higher than in normal breast tissue, and patients with low expression of Lin37 in primary tumors had greater relapse-free survival. Lin37 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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