Differential expression of the DREAM MuvB core complex component Lin37 in cancers of the breast.
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the MuvB core complex and DREAM component Lin37 when comparing primary tumors of the breast to the tissue of origin, the normal breast. Expression of Lin37 in primary tumors of the breast was significantly higher than in normal breast tissue, and patients with low expression of Lin37 in primary tumors had greater relapse-free survival. Lin37 may be of relevance to initiation, maintenance or progression of cancers of the female breast.