scholarly journals CD300LG (Nepmucin) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Messenger Rna ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Global Gene Expression ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Primary Tumors ◽  
The Brain

Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified differential expression of CD300LG as a transcriptional feature of brain metastasis in patients with breast cancer. Messenger RNA for CD300LG was present at significantly lower quantities in the brain metastatic tissues of patients with metastatic breast cancer. Additional microarray analysis revealed that CD300LG was also among the genes whose expression, transcriptome-wide, was most significantly different in primary tumors of the breast when compared to normal breast tissues. CD300LG is part of the transcriptional signature of human metastatic breast cancer.

scholarly journals LINC00968 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Non Coding Rna ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer at the transcriptome-level and in an unbiased fashion. We describe here the differential expression of the long intergenic non-coding RNA LINC00968 in the brain metastatic tissues and primary tumors of women with breast cancer. LINC00968 transcript was present at significantly reduced quantities at in brain metastases and in primary tumors of the breast as compared to untransformed breast tissues. Molecular functions and down-regulation of LINC00968, a non-coding RNA that has not previously been described in relation to central nervous system metastasis in human breast cancer represents a feature of the transcriptional fingerprint of brain metastatic breast cancer in humans and may be relevant to pathways underlying invasion and colonization of the brain.

scholarly journals Aldolase B is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Global Gene Expression ◽  
Breast Cancer Patients ◽  
Clinical Control ◽  
Global Gene Expression Analysis ◽  
Aldolase B ◽  
The Brain

Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified differential expression of aldolase B, encoded by the gene Aldob, an enzyme functioning in the metabolism of fructose (7, 8), as a transcriptional feature of brain metastasis in patients with breast cancer. Aldolase B may be of relevance to processes underlying metastasis to the brain in human metastatic breast cancer.

scholarly journals SEC61A2 is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Messenger Rna ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the Sec61 translocon alpha 2 subunit encoded by SEC61A2 was among the genes whose expression was most different in the brain metastatic tumor tissues of patients with metastatic breast cancer. SEC61A2 messenger RNA was present at significantly increased quantities in metastasis to the brain when compared to normal breast tissues. SEC61A2 was also differentially expressed in primary tumors of the breast when compared to normal breast tissues. Up-regulation of SEC61A2 may be important for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer, and these data suggest that a specific function of the Sec61 translocon may be important for central nervous system metastasis, or that the biosynthesis and transport of integral membrane and secreted proteins more broadly is in higher demand during this process.

scholarly journals The vitamin D receptor is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Metastatic Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Global Gene Expression ◽  
Breast Cancer Patients ◽  
Global Gene Expression Analysis ◽  
Tumor Expression ◽  
The Brain

Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified differential expression of the vitamin D (1α,25(OH)2D3) receptor, encoded by VDR, as a transcriptional feature of brain metastasis in patients with breast cancer. Primary tumor expression of VDR was significantly correlated with overall survival in patients with breast cancer. VDR may be of relevance to processes underlying metastasis to the brain in human metastatic breast cancer.

scholarly journals Fli1 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Global Gene Expression ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Clinical Control ◽  
Global Gene Expression Analysis ◽  
The Brain

Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified Fli1 as a transcriptional feature of brain metastasis in patients with breast cancer. Fli1 may be of relevance to any one of numerous processes involved in metastasis of breast cancers to the brain, including the generation of tumor clones with sufficient oncogenic potential to colonize the brain.

scholarly journals FGF12 is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the fibroblast growth factor 12, encoded by FGF12, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues. FGF12 mRNA expression was significantly higher in brain metastatic tissues as compared to primary tumors of the breast. Up-regulation of FGF12 expression may contribute to metastasis of tumor cells from the breast to the brain in humans with metastatic breast cancer.

scholarly journals C1R is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the complement component 1, r subcomponent, encoded by C1R, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues. C1R mRNA was present at significantly reduced quantities in brain metastatic tissues as compared to primary tumors of the breast. Down-regulation of C1R expression may contribute to metastasis of tumor cells from the breast to the brain in humans with metastatic breast cancer.

scholarly journals HIST1H2BE is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that histone cluster 1, H2be, encoded by HIST1H2BE, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues and primary tumors of the breast. HIST1H2BE mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast and to normal breast tissues. Up-regulation of HIST1H2BE expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals HIST1H3B is differentially expressed in the brain metastases of patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that histone cluster 1, H3b (H3.1), encoded by HIST1H3B, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues and primary tumors of the breast. HIST1H3B mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast and to normal breast tissues. Up-regulation of HIST1H3B expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals PTPRH is a differentially expressed gene in brain metastatic human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tyrosine Phosphatase ◽  
Differentially Expressed Gene ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Normal Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the protein tyrosine phosphatase receptor type H , encoded by PTPRH, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast4, as well as in primary tumors of the breast when compared to normal breast tissue5. PTPRH mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of PTPRH in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of PTPRH expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

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