The relaxin family peptide receptor 1, RXFP1, is differentially expressed in non-small cell lung cancer and associates with patient survival.
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the relaxin family peptide receptor 1, RXFP1, was among those whose expression was most different in human NSCLC tumors as compared to the lung. RXFP1 expression levels were significantly decreased in NSCLC tumors relative to normal lung tissue, and lower expression of RXFP1 in patient tumors was significantly associated with decreased overall survival. RXFP1 may be important for initiation or progression of non-small cell lung cancer in humans.
2020 ◽
2020 ◽
2020 ◽
2020 ◽
2020 ◽
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2020 ◽
2020 ◽
2020 ◽
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