scholarly journals Tyrosine kinases Tie1 and Tie2 are differentially expressed in non-small cell lung cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tyrosine Kinases ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Genes Encoding ◽  
Epidermal Growth

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the genes encoding the tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 - Tie1, and its counterpart Tie2 - were both among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. Tie1 and Tie2 may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals The type III TGF beta receptor is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Transforming Growth Factor ◽  
Patient Survival ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Type Iii

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the type III transforming growth factor (TGF)-β receptor, TGFBR3, was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. TGFBR3 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of TGFBR3 in patient tumors was significantly associated with worse overall survival. We previously reported differential and decreased expression of LTBP4 (5) which associated with patient survival in NSCLC. TGFBR3, and the TGF-β signaling pathway may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals The roundabout guidance receptor 4, ROBO4, is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microarray Data ◽  
Patient Survival ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that ROBO4 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. ROBO4 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ROBO4 in patient tumors was significantly associated with worse overall survival. ROBO4 may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals Glycoprotein M6A is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Gene Encoding ◽  
Human Nsclc ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that gene encoding glycoprotein M6A, GPM6A, was among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. GPM6A expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of GPM6A in patient tumors was significantly associated with worse overall survival. GPM6A may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals RhoJ is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Gene Encoding ◽  
Human Nsclc ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding RhoJ, the ras homolog family member J (RhoJ) among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. RhoJ expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of RhoJ in patient tumors was significantly associated with worse overall survival. RhoJ may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals The relaxin family peptide receptor 1, RXFP1, is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Normal Lung ◽  
Small Cell Lung ◽  
Peptide Receptor ◽  
Relaxin Family

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the relaxin family peptide receptor 1, RXFP1, was among those whose expression was most different in human NSCLC tumors as compared to the lung. RXFP1 expression levels were significantly decreased in NSCLC tumors relative to normal lung tissue, and lower expression of RXFP1 in patient tumors was significantly associated with decreased overall survival. RXFP1 may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals Leucine-rich repeat neuronal 3, LRRN3, is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Leucine Rich Repeat ◽  
Small Cell Lung ◽  
Gene Encoding ◽  
Human Nsclc

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the leucine-rich repeat neuronal 3, LRRN3, was among those whose expression was most different in human NSCLC tumors as compared to the lung. LRRN3 expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of LRRN3 in patient tumors was significantly associated with worse overall survival. LRRN3 may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals ADH1B is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microarray Data ◽  
Patient Survival ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that ADH1B was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. ADH1B expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ADH1B in patient tumors was significantly associated with worse overall survival. ADH1B may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals TCF21 is differentially expressed in non-small cell lung cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microarray Data ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Cancer Death ◽  
Small Cell Lung ◽  
Gene Encoding

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4, 5) to identify differentially expressed genes in NSCLC. We found that the gene encoding the transcription factor TCF21 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. TCF21 may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals The myocardial zonula adherens protein, MYZAP, is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Gene Encoding ◽  
Human Nsclc ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the myocardial zonula adherens protein, MYZAP, was among those whose expression was most different in human NSCLC tumors as compared to the lung. MYZAP expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of MYZAP in patient tumors was significantly associated with worse overall survival. MYZAP may be important for initiation or progression of non-small cell lung cancer in humans.

scholarly journals FHL1 is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Microarray Data ◽  
Patient Survival ◽  
The United States ◽  
Small Cell ◽  
Differentially Expressed ◽  
Small Cell Lung ◽  
Lower Expression

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that FHL1 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. FHL1 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of FHL1 in patient tumors was significantly associated with worse overall survival. FHL1 may be important for initiation or progression of non-small cell lung cancer in humans.

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