IFI44 is differentially expressed in models of coronavirus infection in vivo.

Domain Family ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the La ribonucleoprotein domain family member 6 (LARP6) as a conserved differentially expressed gene following coronavirus infection. LARP6 may be involved in the cellular response to COVID19 infection.

TRIB1 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/yjrh9 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The World ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified tribbles homolog 1, TRIB1 as a conserved differentially expressed gene following coronavirus infection. TRIB1 may be involved in the cellular response to COVID19 infection.

The DNA Damage Inducible Transcript DDIT3 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/dfcbv ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Dna Damage ◽

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the DNA Damage Inducible Transcript DDIT3 as a conserved differentially expressed gene following coronavirus infection. DDIT3 may be involved in the cellular response to COVID19 infection.

The methylenetetrahydrofolate dehydrogenase/cyclohydrolase MTHFD2 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/qt2rz ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

Methylenetetrahydrofolate Dehydrogenase ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the methylenetetrahydrofolate dehydrogenase/cyclohydrolase MTHFD2 as a conserved differentially expressed gene following coronavirus infection. MTHFD2 may be involved in the cellular response to COVID19 infection.

The transcription factor ZBTB43 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/jhnfv ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Transcription Factor ◽

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the transcription factor ZBTB43 as a conserved differentially expressed gene following coronavirus infection. ZBTB43 may be involved in the cellular response to COVID19 infection.

The MAX dimerization protein MXD1 is differentially expressed and transcriptionally induced in multiple models of coronavirus infection.

10.31219/osf.io/8unvq ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

Coronavirus Infection ◽

Human Coronavirus 229E

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined independent public (3) and published (4, 5) datasets, containing transcriptome data from infection models of the human coronavirus 229E, severe acute respiratory syndrome (SARS) coronavirus and Middle East (MERS) coronavirus to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified MXD1 as differentially expressed genes following coronavirus infection in vivo and in vitro, conserved across HCoV, MERS-CoV, and SARS-CoV. MXD1 may be involved in the cellular response to COVID19 infection.

C3ORF19/CCDC174 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/2w7ap ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The World ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified C3ORF19, also known as CCDC174 as a conserved differentially expressed gene following coronavirus infection. C3ORF19 may be involved in the cellular response to COVID19 infection.

MAP3K8 (COT/Tpl-2) is differentially expressed and transcriptionally repressed in models of coronavirus infection.

10.31219/osf.io/m9sv8 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Host Cell ◽

Cellular Response ◽

Human Cell Line ◽

Human Cells ◽

Sars Coronavirus ◽

Lack Of Information ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined three independent datasets (3-5), public (3) and published (4, 5) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus, human coronavirus (HCoV) and SARS coronavirus to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified MAP3K8, also known as COT and Tpl-2 (6-8) as a conserved differentially expressed gene following coronavirus infection in primary human cells, in a human cell line, and in the lungs of infected ferrets. MAP3K8 expression dramatically decreased within 12-24 hours of coronavirus infection, both in the lungs of ferrets infected with SARS coronavirus and in primary human microvascular endothelial cells infected with MERS coronavirus. MAP3K8 may be involved in the cellular response to COVID19 infection or a host cell vulnerability, exploited by coronaviruses.

The transcription factor and basic helix-loop-helix family member e41 BHLHE41 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/dfjx6 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Transcription Factor ◽

Family Member ◽

Cellular Response ◽

Basic Helix Loop Helix ◽

Helix Loop Helix ◽

Lack Of Information ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the transcription factor basic helix-loop-helix family member e41 BHLHE41 as a conserved differentially expressed gene following coronavirus infection. BHLHE41 may be involved in the cellular response to COVID19 infection.

IL6 and IL1RN is differentially expressed and transcriptionally induced in models of SARS coronavirus infection.

10.31219/osf.io/h9bmt ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Sars Coronavirus ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

Coronavirus Infection ◽

Human Coronavirus 229E

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined independent published (3-5) and public (6) datasets, containing transcriptome data from infection models of the human coronavirus 229E and of severe acute respiratory syndrome (SARS) coronavirus to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified IL6 and IL1RN as conserved differentially expressed genes following coronavirus infection. IL6 and IL1RN may be involved in the cellular response to COVID19 infection.