scholarly journals Reproductive Biology 2019: Human Chorionic Gonadotropin–Can Nature’s Own Anti-Rejection Agent Help in reducing chronic Rejection in Solid Organ Transplantation?

2021 ◽  
Author(s):  
Mohd Riyaz Beg
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Organ Transplantation ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Chronic Rejection ◽  
Solid Organ Transplantation ◽  
Hla Antigens ◽  
Solid Organ ◽  
Cardiovascular Profile

The safe changes that go with pregnancy are in a fewdifferent ways like those required for strong organtransplantation. Fruitful pregnancy includes controlleddownregulation of the maternal insusceptibleframework with expanded resilience of fetal cellscommunicating fatherly HLA antigens. This has intercededessentially by human chorionic gonadotrophinwhich has an archived capacity to change the activityof T cells, dendritic cells and common executionercells just as expanding vascularisation.Constant unite dismissal is currently the main sourceof join brokenness and disappointment. Long haulhostile to dismissal treatment is joined by safe inadequacyand an unfriendly cardiovascular profile. Interestingly,by and large, insusceptible capacity is savedin pregnancy and pregnant ladies, by and large, feelwell. As such hCG at first added to ordinary treatmentmay lessen or forestall interminable dismissalin transplantation.

Clinical epigenetics and acute/chronic rejection in solid organ transplantation: An update

2021 ◽  
pp. 100609
Author(s):  
Maria Vasco ◽  
Giuditta Benincasa ◽  
Carmela Fiorito ◽  
Mario Faenza ◽  
Paride De Rosa ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Chronic Rejection ◽  
Solid Organ Transplantation ◽  
Solid Organ

Low-dose of tacrolimus favors the induction of functional CD4+CD25+FoxP3+ regulatory T cells in solid-organ transplantation

2009 ◽  
Vol 9 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Zhen Wang ◽  
Bingyi Shi ◽  
Hailong Jin ◽  
Li Xiao ◽  
Yongwei Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Low Dose ◽  
Solid Organ Transplantation ◽  
Solid Organ

scholarly journals Regulatory T Cells and Kidney Transplantation

2018 ◽  
Vol 13 (11) ◽  
pp. 1760-1764 ◽  
Author(s):  
Paloma Leticia Martin-Moreno ◽  
Sudipta Tripathi ◽  
Anil Chandraker
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Tissue Repair ◽  
Solid Organ Transplantation ◽  
Immunosuppressive Drugs ◽  
Solid Organ ◽  
Effective Expansion ◽  
Conventional Immunosuppression

The ability of the immune system to differentiate self from nonself is critical in determining the immune response to antigens expressed on transplanted tissue. Even with conventional immunosuppression, acceptance of the allograft is an active process often determined by the presence of regulatory T cells (Tregs). Tregs classically are CD4+ cells that constitutively express high levels of the IL-2 receptor α chain CD25, along with the transcription factor Foxp3. The use of Tregs in the field of solid organ transplantation is related specifically to the objective of achieving tolerance, with the goal of reducing or eliminating immunosuppressive drugs as well as maintaining tissue repair and managing acute rejection. A key issue in clinical use of Tregs is how to effectively expand the number of Tregs, either through increasing numbers of endogenous Tregs or by the direct infusion of exogenously expanded Tregs. In order to realize the benefits of Treg therapy in solid organ transplantation, a number of outstanding challenges need to be overcome, including assuring an effective expansion of Tregs, improving long-term Treg stability and reduction of risk-related to off-target, nonspecific, immunosuppressive effects related specially to cancer.

scholarly journals Cytomegalovirus-Responsive CD8+T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease

2017 ◽  
Vol 17 (8) ◽  
pp. 2045-2054 ◽  
Author(s):  
L. E. Higdon ◽  
J. Trofe-Clark ◽  
S. Liu ◽  
K. B. Margulies ◽  
M. K. Sahoo ◽  
...  
Keyword(s):  
T Cells ◽  
Organ Transplantation ◽  
Cd8 T Cells ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Cmv Disease

scholarly journals Heterologous Immunity of Virus-Specific T Cells Leading to Alloreactivity: Possible Implications for Solid Organ Transplantation

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2359
Author(s):  
Gonca E. Karahan ◽  
Frans H. J. Claas ◽  
Sebastiaan Heidt
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Organ Transplantation ◽  
Specific Antigen ◽  
Solid Organ Transplantation ◽  
Adaptive Immune System ◽  
Cross Reactivity ◽  
Solid Organ ◽  
Heterologous Immunity ◽  
Specific Memory

Exposure of the adaptive immune system to a pathogen can result in the activation and expansion of T cells capable of recognizing not only the specific antigen but also different unrelated antigens, a process which is commonly referred to as heterologous immunity. While such cross-reactivity is favourable in amplifying protective immune responses to pathogens, induction of T cell-mediated heterologous immune responses to allo-antigens in the setting of solid organ transplantation can potentially lead to allograft rejection. In this review, we provide an overview of murine and human studies investigating the incidence and functional properties of virus-specific memory T cells cross-reacting with allo-antigens and discuss their potential relevance in the context of solid organ transplantation.

Role of Endothelial Cells in Allograft Rejection

1997 ◽  
Vol 2 (2) ◽  
pp. 105-114 ◽  
Author(s):  
Marlene L Rose
Keyword(s):  
Endothelial Cells ◽  
Mhc Class Ii ◽  
Allograft Rejection ◽  
Chronic Rejection ◽  
Solid Organ Transplantation ◽  
Hla Antigens ◽  
Constitutive Expression ◽  
Class Ii ◽  
Solid Organ ◽  
Antigen Presenting

The immunological properties of endothelial cells suggest they perform a pivotal role in acute and chronic rejection following solid organ transplantation. Their constitutive expression of MHC class II molecules (which initiate allograft rejection by activating CD4 T cells) and accessory molecules allows them to present foreign antigen by both the direct and indirect route to the recipient's immune system. The costimulatory molecules used by endothelial cells appear to differ from those used by traditional antigen-presenting cells such as B cells and dendritic cells. Release of non-HLA antigens from damaged endothelial cells results in a chronic antibody response — possibly contributing to graft vasculopathy and chronic rejection. Further understanding of the factors that regulate MHC class II and accessory molecule expression on endothelial cells could lead to novel strategies of therapeutic intervention.

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