scholarly journals Teleology beyond explanation: What factors influence teleology judgments?

2020 ◽  
Author(s):  
Sehrang Joo ◽  
Sami Yousif ◽  
Joshua Knobe

What do we mean when we say something is for a given purpose? Teleology (i.e., something’s purpose) is often associated with teleological explanation (i.e., an explanation referring to that purpose). For instance, a knife may be for cutting things precisely because its existence can be explained by that purpose. But do people ascribe a telos to an object only if they think that object has a teleological explanation? Experiment 1 examined cases where an object was designed for one purpose but is now widely used for a different purpose, and found that teleology judgments and teleological explanation judgments are dissociable: Only an artifact’s original purpose could serve as an explanation, but its new purpose could also be its telos. Experiments 2-3 identified three factors that influence teleology judgments other than intentional design: present use (i.e., how a community is currently using the artifact), collective recognition (i.e., how a community together characterizes the artifact) and success at a function (i.e., how well the artifact can perform its purpose). Finally, Experiment 4 identified one factor that (perhaps unexpectedly) did not affect teleology judgments. In contrast to its role in teleological explanation, structure- function fit did not impact teleology judgments. Implications for work on object teleology and interpretations of teleological reasoning more generally are discussed.

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
J Usta ◽  
K Racha ◽  
K Boushra ◽  
S Shatha ◽  
B Yolla ◽  
...  

1993 ◽  
Vol 70 (01) ◽  
pp. 177-179 ◽  
Author(s):  
Daniel B Rifkin ◽  
Soichi Kojima ◽  
Mayumi Abe ◽  
John G Harpel
Keyword(s):  

1994 ◽  
Vol 72 (01) ◽  
pp. 001-015 ◽  
Author(s):  
Juan J Calvete

SummaryThe glycoprotein (GP) IIb/IIIa, a Ca2+-dependent heterodimer, is the major integrin on the platelet plasma membrane. On resting platelets GPIIb/IIIa is maintained in an inactive conformation and serves as a low affinity adhesion receptor for surface-coated fibrinogen, whereas upon platelet activation signals within the cytoplasma alter the receptor function of GPIIb/IIIa (inside-out signalling), which undergoes a measurable conformational change within its exoplasmic domains, and becomes a competent receptor for soluble fibrinogen and some other RGD sequence-containing plasma adhesive proteins. Upon ligand binding, further structural alterations trigger the association of receptor-occupied GPIIb/IIIa complexes with themselves within the plane of the membrane. The simultaneous binding of dimeric fibrinogen molecules to GPIIb/IIIa clusters on adjacent platelets leads to platelet aggregation, which promotes attachment of fibrinogen-GPIIb/IIIa clusters to the cytoskeleton (outside-in signalling). This, in turn, provides the necessary physical link for clot retraction to occur, and generates a cascade of intracellular biochemical reactions which result in the formation of a multiprotein signalling complex at the cytoplasmic domains of GPIIb/IIIa. Glycoprotein IMIIa, also called αIIbβ3 in the integrin nomenclature, plays thus a primary role in both platelet adhesion and thrombus formation at the site of vascular injury. In addition, the human glycoprotein Ilb/IIIa complex is the most thoroughly studied integrin receptor, its molecular biology and major features of its primary structure having been elucidated mainly during the last six years. Furthermore, localization of functionally relevant monoclonal antibody epitopes, determination of the cross-linking sites of inhibitory peptide ligands, proteolytic dissection of the isolated integrin, and analysis of natural and artificial GPIIb/IIIa mutants have recently provided a wealth of information regarding structure-function relationships of human GPIIb/IIIa. The aim of this review is to summarize these many structural and functional data in the perspective of an emerging model. Although most of the interpretations based on structural elements of this initial biochemical model require independent confirmation, they may help us to understand the structure-function relationship of this major platelet receptor, and of other members of the integrin superfamily, as well as to perform further investigations in order to test current hypotheses.


Author(s):  
John A. Romberger ◽  
Zygmunt Hejnowicz ◽  
Jane F. Hill

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