Transdiagnostic clinical staging for childhood mental health: An adjunctive tool for classifying internalizing and externalizing syndromes that emerge in children aged 5-11 years

Clinical staging is now recognized as a key tool for facilitating innovation in personalized and preventative mental health care. It places a strong emphasis on the salience of indicated prevention, early intervention, and secondary prevention of major mental disorders. By contrast to established models for major mood and psychotic syndromes that emerge after puberty, developments in clinical staging for childhood-onset disorders lags significantly behind. In this article, criteria for a transdiagnostic staging model for those internalizing and externalizing disorders that emerge in childhood is presented. This sits alongside three putative pathophysiological profiles (developmental, circadian, and anxious-arousal) that may underpin these common illness trajectories. Given available evidence, we argue that it is now timely to develop a transdiagnostic staging model for childhood-onset syndromes. It is further argued that a transdiagnostic staging model has the potential to capture more precisely the dimensional, fluctuating developmental patterns of illness progression of childhood psychopathology. Given potential improvements in modelling etiological processes, and delivering more personalized interventions, transdiagnostic clinical staging for childhood holds much promise for assisting to improve outcomes. We finish by presenting an agenda for research in developments of transdiagnostic clinical staging for childhood mental health.

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Validating Screening Questionnaires for Internalizing and Externalizing Disorders against Clinical Interviews in 8 to 17-Year-Old Syrian Refugee Children

10.31234/osf.io/6zu87 ◽

2021 ◽

Author(s):

Fiona McEwen ◽

Patricia Moghames ◽

Tania Bosqui ◽

Vanessa Kyrillos ◽

Nicolas Chehade ◽

...

Keyword(s):

Mental Health ◽

Functional Impairment ◽

Mental Health Problems ◽

Externalizing Disorders ◽

Parent Report ◽

Health Problems ◽

Self Report ◽

Refugee Children ◽

Screening Questionnaires ◽

Internalizing And Externalizing

Syrian children affected by the civil war are at increased risk of mental health problems, including depression, anxiety, post-traumatic stress disorder (PTSD), and externalizing behaviour problems. Screening questionnaires are designed to identify individual children who require further assessment and treatment, and also estimate the need for mental health services in a population. However, few questionnaires have been rigorously tested in this population. This study examined the reliability and validity of questionnaires for depression (Center for Epidemiological Studies Depression Scale for Children, CES-DC, self-report, 10-item version), anxiety (Screen for Child Anxiety Related Emotional Disorders, SCARED, self-report, 18-item version), PTSD (Child PTSD Symptom Scale, CPSS, self-report), and internalizing and externalizing behavior problems (Strengths and Difficulties Questionnaire, SDQ, parent-report version) in a population sample of 8-17 year old Syrian children living in Informal Tented Settlements (ITS) in the Beqaa region of Lebanon. In addition, several ways of measuring functional impairment due to mental health problems were compared. These included self- and parent-report questionnaires (World Health Organization Disability Assessment Schedule, WHODAS-Child; SDQ Impact supplement, parent-report only) and an interviewer rating of severity (Clinical Global Impression–severity, CGI-s). Questionnaires were translated into Arabic and modified based on pilot testing with Syrian children. Responses from N=1006 children and caregivers were used for analysis, a subset of whom had additional clinical interview data (MINI KID + clinical judgement; N=119). The self-report questionnaires showed good internal consistency reliability with alpha>.80, though the parent-report SDQ and WHODAS-Child fell below this level. In terms of validity, the SDQ externalizing scale performed well in differentiating children with conduct problems from those without and it was possible to achieve a fair balance between sensitivity (82%) and specificity (71%). The CES-DC, CPSS, SDQ total difficulties, and WHODAS-Child (selfreport) achieved an acceptable level of validity, though it was harder to achieve a good balance between sensitivity and specificity. In most cases, at least 50% of those screening positive were false positives, meaning that a more in-depth follow up assessment would be required if these tools were used as screeners in a clinical setting. Furthermore, correctionwould be needed if used to estimate prevalence rates for mental disorders in this population. There was moderate convergent validity between measures of functional impairment, with self-report WHODAS-Child showing greater agreement with interviewer ratings when compared to parent-report measures (WHODAS and SDQ Impact). Measuring functional impairment and distress due to mental health problems should help to differentiate children with clinically significant mental health problems from those with subthreshold problems; however, more work will be required to establish how helpful the tools used here are in achieving that aim.

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Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care

Annual Review of Developmental Psychology ◽

10.1146/annurev-devpsych-050620-030405 ◽

2021 ◽

Vol 3 (1) ◽

Author(s):

Patrick D. McGorry ◽

Cristina Mei

Keyword(s):

Mental Health ◽

Mental Disorders ◽

Developmental Psychology ◽

Clinical Care ◽

Clinical Staging ◽

Annual Review ◽

Publication Date ◽

Diagnostic Systems ◽

Illness Progression ◽

Selection Of

Current silo-based diagnostic systems for mental disorders lack utility and fail to fulfil a fundamental purpose of diagnosis: to guide treatment planning and predict outcomes. Diagnostic reform has gained momentum, and clinical staging has emerged as a promising framework to improve the precision of diagnosis, particularly in early illness stages, and fill current gaps in linking diagnosis to more personalized and effective intervention, prognosis, and neurobiological markers. Transdiagnostic clinical staging recognizes that the early development of mental ill-health is marked by substantial fluidity and that symptoms may, although not inevitably, evolve into more stable diagnosable syndromes. Staging facilitates the selection of interventions that are proportionate to the current need and risk of illness progression and provides an efficient framework to organize biomarker data and guide service delivery. Here, we provide an overview of transdiagnostic clinical staging and summarize key evidence supporting its ability to integrate biomarkers and guide mental health care. Expected final online publication date for the Annual Review of Developmental Psychology, Volume 3 is December 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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