In children acute severe asthma is a serious condition. The inhaled route for drug delivery is not appropriate when only small respiratory gas volumes are shifted; the i.v. route may be associated with greater side effects. Magnesium sulphate IV has a place in acute asthma management because it is a mild bronchodilator, and has a stabilizing effect on the atria.
Objective: To compare the effectiveness of intravenous magnesium sulphate versus intravenous aminophylline in acute attack of asthma.
Study Design: Randomized control trial.
Setting: Emergency Department of pediatric
Duration: April 2017 to October 2017.Material & Methods: 60
cases were included in the study. They were randomly divided in two comparable groups. Children in group A ware treated with intravenous magnesium sulphate and group B with intravenous aminophylline. The efficacy of the drug was judged by the improvement in the sign observed like respiratory rate (less than 40 per minute), pulse rate(<100), oxygen saturation( above 90 %) assessed after the time period of three hours.
Results: Effectiveness of intravenous magnesium sulphate in acute attack of asthma was found in 28 cases in Group A (93.33%) and in 22 cases in Group B (73.33%) with p-value 0.03. However, 6.67% cases (2 cases) in Group A and 26.67% cases (8 cases) in Group B did not show effectiveness.
Conclusion: The clinical efficacy of intravenous magnesium sulphate in managing case of acute severe asthma was better when compared with intravenous aminophylline.
Intravenous magnesium sulphate as an adjuvant in acute severe asthma refractory to conventional therapy
