scholarly journals Nerve Conduction Study in Healthy Individuals: a Gender Based Study

1970 ◽  
Vol 8 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Dilip Thakur ◽  
BH Paudel ◽  
BK Bajaj ◽  
CB Jha
Keyword(s):  
Action Potential ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Muscle Action ◽  
Muscle Action Potential ◽  
Sensory Nerve Action ◽  
Motor Nerves

Background: Nerve conduction study (NCS) assesses peripheral nerve functions and has clinical implication. Objective: To study effect of gender on NCS variables in healthy adults. Settings and Design: Department of Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Material and Method: The study was done in 34 (m=19, 32±11 years; f=15, 32±12 years) consenting healthy adults. The compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) were recorded. Statistical analysis: The effect of gender on NCS variables was analyzed using Mann Whitney U test. Results: Male vs. female: males had increased CMAP and F-wave latencies (ms) in all tested motor nerves. CMAP duration (ms) was longer in males (p<0.05) in all tested motor nerves: right median (5.9±1.3 vs. 4.92±0.65), left median (5.54±0.91 vs. 4.72±0.57), right ulnar (5.55±1.01 vs. 4.56±0.59), left ulnar (5.71±0.97 vs. 4.64±0.51), right tibial (6.58±0.95 vs. 5.95±0.71), and left tibial (6.98±1.31 vs. 6.21±0.78). Females showed higher sural SNAP amplitude (µV) (23.26±9.23 vs. 15.94±8.42). SNAP duration (ms) was longer in males: right ulnar (1.16±0.19 vs. 1.03±0.06). SNAP latencies (ms) were also longer in males: right sural (2.61±0.44 vs. 2.21±0.36). Males had greater height (165.9±4.74 vs. 149.3±7.24) and weight (60.4±7.2 vs. 53±7.2).Conclusion: Gender has definite effects on NCS variables. Males had higher CMAP amplitude, longer latencies and duration. SNAP latencies and duration were longer in males whereas amplitude was higher in females. Without adjustment for these factors, the sensitivity and specificity of NCS will decrease when using the same reference data in patients with different gender. Keywords: compound muscle action potential; gender; nerve conduction study; sensory nerve action potential DOI: 10.3126/hren.v8i3.4210Health Renaissance, September-December 2010; Vol 8 (No.3);169-175

scholarly journals Nerve Conduction study in healthy individuals, a preliminary age based study

2012 ◽  
Vol 8 (3) ◽  
pp. 311-316 ◽  
Author(s):  
D Thakur ◽  
B H Paudel ◽  
C B Jha
Keyword(s):  
Action Potential ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Muscle Action ◽  
Potential Amplitude ◽  
Muscle Action Potential ◽  
Motor Nerves ◽  
Effect Of Age

Background Nerve conduction study assesses peripheral nerve functions and has clinical implication. Objectives To study the effect of age on nerve conduction study variables in healthy adults. Methods Cross sectional study was done from Jan 2006 to Dec 2006 in department of Physiology, BP Koirala Institute of Health Sciences, Dharan, Nepal. The study was done in 34 (younger, n= 18, 17 to 29 years; older, n= 16, 30 to 57 years) consenting healthy adults of either sex. The compound muscle action potential and sensory nerve action potential were recorded using standard technique. Due to the non-normal distribution of data, the effect of age on nerve conduction study variables was analyzed using Mann Whitney U test. Results Younger vs. older individuals: older had lower Compound Muscle action potential amplitude (mV) in all motor nerves except radial and left ulnar nerves. Compound Muscle action potential duration (ms) was shorter in older (p<0.05) in ulnar, tibial, right median and left common peroneal motor nerves than the younger: right median (6.92±1.3 vs. 8.5±1.88), right ulnar (7.09±1.54vs. 8.2±1.31), left ulnar (10.56±1.44 vs. 12.06±1.5), right tibial (6.28±0.81vs. 7.28±1.12), and left tibial (9.58±1.52vs.10.78±1.71). Sensory nerve actional potential amplitude (?V) was smaller in older as compared to younger: right median (19.01±7.83 vs. 26.97±10.63), right ulnar (10.9±3.44 vs.16.09±5.85) and right radial (14.31±4.34 vs.19.72±6.47). SNAP duration (ms) was longer in older: right ulnar (1.34±0.17 vs.1.26± 0.18), left ulnar (1.46±0.14 vs. 1.29±0.26), and left median (1.11± 0.14 vs. 1± 0.14). Conclusions Age has definite effects on amplitude and duration of motor and sensory nerves. Different nerves have different timing of aging. Without adjustment for age, the sensitivity and specificity of nerve conduction study will decrease whenusing the same reference data in patients with different age.DOI: http://dx.doi.org/10.3126/kumj.v8i3.6218 Kathmandu Univ Med J 2010;8(3):311-6

The correlation of neurophysiological findings with clinical and functional status in patients following traumatic nerve injury

2013 ◽  
Vol 39 (2) ◽  
pp. 199-206 ◽  
Author(s):  
F. Şahin ◽  
N. Ş. Atalay ◽  
N. Akkaya ◽  
Ö. Ercidoğan ◽  
B. Başakçı ◽  
...  
Keyword(s):  
Action Potential ◽  
Functional Status ◽  
Nerve Injury ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Muscle Action ◽  
Nerve Action ◽  
Muscle Action Potential ◽  
Sensory Nerve Action

In this study, we aimed to determine whether there is a correlation between the electrodiagnostic findings and the functional status, muscle strength and sensibility in patients with traumatic nerve injury to the wrists. We assessed 50 patients at a mean of 11.6 months (SD 5.85) (range 6–25) after nerve injury. Sensibility was assessed by monofilament testing. Motor function was evaluated by assessing the manual muscle grade of the abductor pollicis brevis and abductor digiti minimi muscles. Function was evaluated by the Sollerman Hand Function Test. The amplitudes of the compound muscle action potential and the sensory nerve action potential were determined by electroneuromyography. While the compound muscle action potential and sensory nerve action potential amplitudes had significant correlation with muscle grade and Semmes Weinstein Monofilament tests, there was no correlation with the functional scores.

scholarly journals Clinical predictors of surgical outcomes of severe carpal tunnel syndrome patients: utility of palmar stimulation in a nerve conduction study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuichi Sasaki ◽  
Tohru Terao ◽  
Emiko Saito ◽  
Keiichiro Ohara ◽  
Shotaro Michishita ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Action Potential ◽  
Carpal Tunnel ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Muscle Action ◽  
Muscle Action Potential ◽  
Sensory Nerve Action ◽  
Tunnel Syndrome

Abstract Background Carpal tunnel syndrome is a common peripheral nerve compression disorder. However, there is no established opinion regarding the predictors of symptom improvement after surgery. This study aimed to identify the predictors of surgical outcomes of severe carpal tunnel syndrome patients. Methods In the patients who underwent a carpal tunnel syndrome surgery, we selected the patients who had a preoperative Bland’s classification of grade 5 or 6, and assessed for the changes in Bland’s classification grade before and after surgery. Those who showed improvement from preoperative grades 5–6 to postoperative grades 1–4 comprised the improvement group. In contrast, those who did not show improvement and had postoperative grades 5 or 6 comprised the non-improvement group. In a nerve conduction study, amplitudes of the compound muscle action potential and sensory nerve action potential of the palms were assessed between the improvement and non-improvement groups. Results Among the 60 hands of 46 patients who had a preoperative Bland’s classification of grade 5 or 6, 49 hands of 37 patients comprised the improvement group, and 11 hands of 9 patients comprised the non-improvement group. The amplitudes of the compound muscle action potential and sensory nerve action potential of the palms before surgery were significantly higher in the improvement group. The degree of improvement in Bland’s classification grade was correlated with the degree of clinical symptom improvement. Conclusions Amplitudes of compound muscle action potential and sensory nerve action potential before surgery induced by palmar stimulation can predict improvements in nerve conduction study scores and clinical findings after surgical treatment.

scholarly journals Normal neurophysiologic parameters of the median nerve among adult healthy Sudanese population

2020 ◽  
Vol 10 (4) ◽  
pp. 136-141
Author(s):  
Mohammed Salah Elmagzoub ◽  
Ahmed Hassan Ahmed ◽  
Hussam M A Hameed
Keyword(s):  
Action Potential ◽  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Peak Latency ◽  
Muscle Action Potential ◽  
Sensory Nerve Action

Background: Nerve conduction studies (NCSs) help in delineating the extent distribution of neural lesion, and the diagnosis of peripheral nerve disorders. Because normative nerve conduction parameters were not yet established in Sudan EMG laboratories, this study aims towards having our own reference values, as we are using the American and British parameters. This will allow avoiding the discrepancies that might be induced by many factors. Methods: NCSs were performed in 200 Median nerves of 100 adult healthy Sudanese subjects using standardized techniques. Results: The median SNAP (sensory nerve action potential) values were as follows: distal latency, 2.6±3 ms with a range of (2.3-2.9); peak latency, 3.5±0.5 ms (3.0-4.0); amplitude, 47.7±18.0μV (29.7-65.7); conduction velocity, 53.0±7.8 m/s (45.2-60.8). The following values were obtained for the Median nerve CMAP (compound muscle action potential) at wrist stimulation: distal latency, 3.5±0.5 ms with a range of (3.0-4.0); peak latency, 9.4± 1.0 ms (8.4-10.4); duration, 5.9±0.9 ms (5.0-6.8); amplitude, 12.3±2.5 mV (9.8-14.8); area, 43.0±10.4 mVms (32.6-53.4); conduction velocity, 63.6±6.2 m/s (57.4-69.8). The F wave was 28.4±1.8 ms (26.6-30.2). Conclusion: The overall mean sensory and motor nerve conduction parameters for the tested nerve compared favorably with the existing literature with some discrepancies that were justified.

Nerve physiology

2017 ◽  
Author(s):  
Matthew Pitt
Keyword(s):  
Action Potential ◽  
Normative Data ◽  
Axonal Degeneration ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Muscle Action ◽  
Nerve Fibres ◽  
Muscle Action Potential ◽  
Motor Nerves ◽  
F Wave

The chapter begins with a description of the normal findings in healthy sensory and motor nerves. The distribution of nerve fibres by diameter in the sensory nerve and its effect on the recorded action potential is outlined. The method by which velocity and compound muscle action potential are derived from motor stimulation follows. H-reflex studies and F-wave identification are described. A section on the strategies used for nerve conduction study in children and the nerves chosen for examination leads on to a description of the difficulties of deriving normative data in children. Next follows a detailed description of the findings in both sensory and motor nerves in demyelination where a distinction between patchy and homogenous demyelination is possible. An analysis of the nerve findings in axonal degeneration is then presented. The chapter finishes with a discussion of the variability in nerve testing.

Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

2019 ◽  
Vol 18 (04) ◽  
pp. 182-184
Author(s):  
Roshan Koul ◽  
Saleem Saleh Naiha Al Harousi ◽  
Sousan AlNabhani ◽  
Amna AlFutaisi
Keyword(s):  
Retrospective Study ◽  
Action Potential ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Compound Muscle Action Potential ◽  
University Hospital ◽  
Muscle Action ◽  
Sultan Qaboos University ◽  
Muscle Action Potential ◽  
Vincristine Neuropathy

Abstract Objective The main objective of this article was to evaluate vincristine neuropathy effect on common peroneal and tibial nerves. Methods A retrospective study was conducted in children with vincristine neuropathy between August 2006 and January 2016 at Sultan Qaboos University Hospital. Results Twenty-eight children (15 females and 13 males) were included in the study. The compound muscle action potential of common peroneal nerves was significantly reduced relative to the tibial nerves (p < 0.05)). There was no difference in latency and nerve conduction velocity between the two nerves. Conclusion Children receiving vincristine demonstrate severe peroneal neuropathy compared with tibial nerves. We conclude that squatting posture effects peroneal nerves and postulate that the peroneal nerves are affected more due to the squatting posture. This squatting posture stretches the nerves that are already affected by the toxic effect of vincristine.

scholarly journals Injection nerve palsy

2013 ◽  
Vol 04 (01) ◽  
pp. 13-18 ◽  
Author(s):  
Arindhom Kakati ◽  
Dhananjaya Bhat ◽  
Bhagavathula Indira Devi ◽  
Dhaval Shukla
Keyword(s):  
Action Potential ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Motor Deficit ◽  
Nerve Action ◽  
Muscle Action Potential ◽  
Sensory Nerve Action ◽  
Operative Findings ◽  
Case Outcome ◽  
Outcome Of Surgery

ABSTRACT Objective: To study the clinical profile and outcome of surgery for injection nerve palsies. Materials and Methods: This is a retrospective study of patients with INP who were treated at our institute during May 2000 to May 2009. Clinical, electroneuromyography (ENMG), and operative findings were noted. Intraoperative nerve action potential monitoring was not used in any case. Outcome of patients who were followed was reviewed. Results: INP comprised 92 (11%) of 837 nerve injury patients. Seventy one patients were children less than 16 years. The nerves involved were sciatic in 80 patients, radial in 8, and others in four. Fifty seven patients had power, grade 0/5. ENMG studies revealed absent compound muscle action potential in 64 and absent sensory nerve action potential in 67 patients. Thirty nine (42.3%) of 92 patients underwent surgery. The mean duration since injury in these patients was 5.2 months (3 months to 11 months). All underwent neurolysis. Only 18 patients who underwent surgery had a follow up of more than 3 months. Ten (55.5%) patients had good or fair outcome after surgery. Except for grade of motor deficit prior to surgery, none of the variables were found to significantly affect the outcome. Conclusion: The outcome of INP is generally good and many patients recover spontaneously. The outcome of surgery is dependent on preoperative motor power.

scholarly journals Role of Electro-Diagnostic Tests In Early Detection of Diabetic Neuropathy

1970 ◽  
Vol 24 (1) ◽  
pp. 34-44
Author(s):  
Zahed Ali ◽  
Maliha Hakim ◽  
Monirul Islam ◽  
Nirmalendu Bikash Bhowmik ◽  
Shamsun Nahar ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Action Potential ◽  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Sensory Nerve ◽  
Diabetic Patients ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action

Since the peripheral nerve has the ability to regenerate, therapeutic intervention at earlier stages expected to have a better result in the treatment of diabetic neuropathy. So early detection of diabetic neuropathy is one of the major goals in its management. Purpose: The purpose of present study is to evaluate the efficacy of the electrodiagnostic tests to detect diabetic neuropathy at an early stage (before development of the signs of neuropathy). Method: 30 diabetic patients with or without symptoms of diabetic neuropathy were included in the test group. Diabetic patients with signs of neuropathy and with other complications, like stroke, peripheral vascular diseases were excluded. Twenty six control subjects (non-diabetic with no family history of diabetes) were included. Both the groups were matched for age. To see the functional status of peripheral nerves motor nerve conduction velocity (NCV), compound muscle action potentials (CAMP) of median nerve were studied. Sensory nerve conduction velocities (NCV), and sensory nerve action potential (SNAP) of median and sural nerves were also measured. Results: Sensory nerve conduction velocity of sural nerve was significantly slowed (43.84±8.23 vs 48.23±5.03 m/sec, p < .05) in diabetic patients. Sural sensory nerve action potential has lower in amplitude (13.31±7.03 vs 14.24±4.714 mv, p<.3) in diabetic patients. Median sensory nerve conduction velocity did show difference (50.89+8.23 vs 57.17±6.67 m/s, p < .01) and median sensory nerve action potential has significantly lower in amplitude (3.86±1.016 vs 7.39±4.79, p < .001) in diabetic patients. No significant difference was found in median nerve motor conduction velocity between the two groups of subjects. Amplitude of compound muscle action potential of median nerve also shows no significant variations.Considering mean±SD value of conduction parameter as the cut off value, sural nerve sensory conduction velocity was found slowed in 8 diabetic subjects (26%). Sural nerve sensory action potential was of lower amplitude in 12 diabetic subjects (40%). Eleven diabetic subjects (36%) had lower amplitude for median sensory nerve action potential (SNAP). For compound muscle action potential (CAMP) and sensory nerve action potential (SNAP) half the mean value of control was the cut off point. Conclusion: The result suggests that in diabetic patients of Bangladesh with or without symptoms of neuropathy, abnormalities of nerve conduction parameters can be detected early by routine electrodiagnostic monitoring. Sensory nerve conduction parameters are affected more than motor ones. Amplitude abnormalities are slightly more common than conduction velocity or latency abnormalities for sensory studies. Lower extremity nerves were affected more. Sural median nerve has the highest abnormalities in diabetic patients with early neuropathy. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3038 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) :34-44

Motor Nerve Conduction Studies

2016 ◽  
pp. 257-291
Author(s):  
Lyell K. Jones ◽  
James C. Watson
Keyword(s):  
Action Potential ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Conduction Block ◽  
Neuromuscular Diseases ◽  
Muscle Action ◽  
Motor Nerve Conduction ◽  
Muscle Action Potential ◽  
Nerve Disease

A compound muscle action potential (CMAP) is the summated action potential recorded from muscle during a motor nerve conduction study (NCS). Motor NCSs with recording of CMAPs may be used for several purposes in assessing neuromuscular diseases, including providing objective measurements of the extent and localization of the cause of weakness; determining the underlying pathological abnormality, such as conduction block or slowing of conduction at a localized area of neurapractic injury; identifying the changes associated with Wallerian degeneration and regeneration in the motor nerve; and assisting (along with needle EMG) in distinguishing peripheral nerve disease from lower motor neuron disease, neuromuscular junction disease, and myopathies. This chapter will review the concepts and techniques of motor NCS and CMAP recording, will describe the technique and measurements, and will discuss the findings in various neuromuscular diseases.

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