scholarly journals Ovarian Germ Cell Tumor – Histopathological and statistical analysis

2013 ◽  
Vol 3 (6) ◽  
pp. 441-446
Author(s):  
A Ghosh ◽  
D Magar Gharti ◽  
B Sathian ◽  
R Narasimhan ◽  
Op Talwar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Mature Cystic Teratoma ◽  
Age Group ◽  
Malignant Germ Cell Tumors

Background: Ovarian cancers are common among females. The ovarian tumors are classified according to its histogenesis. In the present study, we analyzed the germ cell ovarian tumors reported in our institute. Materials and Methods: This study was a hospital based retrospective study. All ovarian germ cell tumor reported from Jan 2001 to Feb 2013 were retrieved and analyzed. The specimens were routinely processed and the slides were stained with H&E and special stains wherever required. Results: A total of 340 cases of ovarian tumors were reported and 150 cases (44%) were of germ cell origin. We had 137 cases of benign and 13 cases of malignant germ cell tumors. Most common subtype was mature cystic teratoma comprising 125 cases. Among the malignant cases, the most common was immature teratoma (5 cases). Age range in our series was from 8 to 82 years (mean 28 years). The most common age group affected was 21-30 years. Most of the malignant cases (76.9%) were in less than 30 years. Among the malignant cases majority (84.6%) were more than 10 cm in size. None of the malignant germ cell tumors were bilateral. Conclusion: Among germ cell tumors of ovary, mature cystic teratoma is the most common tumor and malignant subtypes are uncommon. Malignant tumors tend to occur in younger age group. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8990 Journal of Pathology of Nepal (2013) Vol. 3, 441-446

scholarly journals Clinicopathological study of benign ovarian tumuors

2018 ◽  
Vol 6 (8) ◽  
pp. 2750
Author(s):  
Nikita V. Vohra ◽  
Cyrus Dara Jokhi ◽  
Sujata R. Kanetkar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Malignant Tumors ◽  
Ovarian Neoplasm ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Age Group ◽  
Common Procedure ◽  
Epithelial Tumour

Background: The incidence of ovarian tumor amongst gynecological admissions have been reported to vary from 1-3 %. About 75% of these tumors have been found to be benign. Ovarian malignancies represent the greatest clinical challenge of all the gynecological malignancies. During the reproductive years most of the ovarian tumors encountered are benign. About 2/3 of the ovarian tumors are encountered in this group only. The chance that an ovarian tumor is malignant in a patient younger than 45 years is 1 in 15. The differentiation of the benign from malignant tumors can go wrong even with imaging modalities.CA125 along with ultrasound are useful in differentiating benign from malignant tumors. Histopathological examination is gold standard for diagnosis of ovarian neoplasm.Methods: The present study includes consecutive cases of histopathologically proven ovarian tumors of 3 years from June 2010 to May 2013 reported by the Department of Pathology of our tertiary care center. It includes total 150 cases. After careful study of gross findings, appropriate bits were taken from received ovarian specimen, followed by routine paraffin processing to make H and E stained slides. Special stains were used wherever needed.Results: Majority of the cases 91 (60.67%) were benign, 53 (35.33%) were malignant and 6 (4.0%) were borderline. Surface epithelial tumours were the most common type (68.13%) of ovarian neoplasm in this study. Most of tumours in our study occurred in the age group of 21-40 years. Mucinous cystadenomas were most common benign surface epithelial tumour and most common benign tumors overall. There were 22 cases of benign germ cell tumor, all were mature teratoma. All the sex-cord stromal tumours were diagnosed in women older than 40 years. Most common benign lesion in our study is surface epithelial tumour and in age group of 21-40 years. 84% patients studied had symptoms at presentation, out of which 26% of patient presented with dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management.Conclusions: Most of ovarian neoplasm are benign with mucinous cystadenoma being commonest entity. Commonest age group is 21-40 years. Commonest benign germ cell tumor is Mature cystic teratoma. Commonest clinical symptom is dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management. 

scholarly journals Study of malignant germ cell tumors with special reference to malignant ovarian germ cell tumors: 5 years experience

2012 ◽  
Vol 2 (4) ◽  
pp. 289-292 ◽  
Author(s):  
R Jha ◽  
S Jha
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
University Teaching ◽  
Age Group ◽  
Common Site ◽  
Large Size ◽  
Malignant Germ Cell Tumor ◽  
Malignant Germ Cell Tumors

Background: Germ cell tumors are rare and complex group of heterogenous neoplasms that comprise both benign and malignant histology. The testes and ovaries are the most common sites. This descriptive study focused on distribution of malignant germ cell tumors with more detail study of ovarian malignant germ cell tumors.Materials and Methods: All cases of malignant germ cell tumor reported from department of pathology of Tribhuvan University Teaching Hospital over five years from April 2007 to April 2012 were included in the study.Results: Thirty five cases (24 female and 11 male) were diagnosed as having malignant germ cell tumors. Most patients were below 30 years of age. Ovary was the most common site followed by testes. Malignant ovarian germ cell tumor comprised 54.3% of all malignant germ cell tumors. Age of these patients ranged from 6 years to 32 years. Most common histologic type was yolk sac tumor.Conclusion: Malignant germ cell tumors can be seen in any age group from new born to old age. However malignant ovarian germ cell tumors occur mainly in first three decades of life, are mostly unilateral and are of large size at the time of diagnosis due to rapid growth. However these tumors are often of low stage and managed with conservative surgery.Journal of Pathology of Nepal (2012) Vol. 2, 289-292DOI: http://dx.doi.org/10.3126/jpn.v2i4.6880

Mature Cystic Teratoma of the Lung With a Somatic-Like Malignant Component in a Patient With Testicular Germ-Cell Tumor

2018 ◽  
Vol 54 (12) ◽  
pp. 629-630
Author(s):  
Ana Vallejo-Benítez ◽  
Enrique Rodríguez-Zarco ◽  
Sofia Pereira-Gallardo ◽  
Laura Macías-García
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cystic Teratoma ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Mature Cystic Teratoma ◽  
Testicular Germ Cell

scholarly journals Spectrum of ovarian tumors in a referral hospital in Nepal

2014 ◽  
Vol 4 (7) ◽  
pp. 539-543 ◽  
Author(s):  
S Vaidya ◽  
P Sharma ◽  
S KC ◽  
SA Vaidya
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Age Distribution ◽  
Germ Cell Tumors ◽  
Clinical Manifestations ◽  
Cystic Teratoma ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Benign Tumors ◽  
Malignant Germ Cell Tumors

Background: Ovarian tumors are common forms of neoplasia in women. Among cancers of the female genital tract, it ranks only below carcinoma of the cervix and the endometrium, but is responsible for approximately 50% of the deaths. They arise from different cell lineages and hence constitute a wide variety of neoplastic entities with diverse morphological and clinical manifestations. Materials and Methods: A descriptive study of 363 cases of ovarian tumors was carried out during a three year period from January 2011 to December 2013. Results: Of the 363 ovarian tumors, 293 (80.72%) cases were benign, 57 (15.70%) were malignant and 13 (3.58%) were borderline. Germ cell tumour was the most common class of tumour and seen in 187 (51.52%) cases, followed by surface epithelial in 158 (43.53%) cases. The age distribution of the patients ranged from 10-82 years with a median age of 33 years. Benign tumors were more common than malignant ones in all age groups. Conclusion: Most of the ovarian tumors in this study were of germ cell origin. The incidence of malignant germ cell tumors was also significantly higher than in other studies. Mature cystic teratoma was the most common benign tumour while serous carcinoma was the most common malignancy. The incidence of malignant germ cell tumors was higher compared to other studies. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10295 Journal of Pathology of Nepal (2014) Vol. 4, 539-543

Mature Cystic Teratoma of the Lung With a Somatic-Like Malignant Component in a Patient With Testicular Germ-Cell Tumor

2018 ◽  
Vol 54 (12) ◽  
pp. 629-630
Author(s):  
Ana Vallejo-Benítez ◽  
Enrique Rodríguez-Zarco ◽  
Sofia Pereira-Gallardo ◽  
Laura Macías-García
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cystic Teratoma ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Mature Cystic Teratoma ◽  
Testicular Germ Cell

scholarly journals Metastatic germ cell tumor with complete response-7 years follow up

2017 ◽  
Vol 5 (12) ◽  
pp. 5443
Author(s):  
Branislava Golub Jakovljevic ◽  
Dejan Đokanović ◽  
Snježana Miličević ◽  
Anđa Škobić ◽  
Dejan Ćazić ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Complete Response ◽  
Cell Tumor ◽  
Uncommon Disease ◽  
Malignant Germ Cell Tumors ◽  
Sites Of Metastases ◽  
Very High

Cancer of the testis is a relatively uncommon disease, accounting for approximately 1-1.5% of all cancers in males.  5% of the malignant germ cell tumors are made of extragonadal origin. Germ cell tumors occur in men younger, usually between 20 and 35 years old. We report a case of a patient with metastatic extragonadal germ cell tumor with multiple sites of metastases, and very high initial values of tumor marker human chorionic gonadotrophin (HCG)- 1351308. At the time of diagnosis, the patient was in a very poor general condition. After the applied chemotherapy, there was a complete response and 7 years later the patient is without any symptoms of disease.

Endoscopic Transnasal Resection of Suprasellar Teratoma

2019 ◽  
Vol 80 (04) ◽  
pp. 320-324
Author(s):  
Abdulrazag M. Ajlan ◽  
Abdulrahman Albakr ◽  
Saad Alsaleh ◽  
Hisham Alkhalidi
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Nerve Palsy ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Cell Tumor ◽  
Oculomotor Nerve Palsy ◽  
Double Vision ◽  
Transnasal Approach ◽  
Anterior Clinoid Process

Background Intracranial teratomas are rare tumors that usually present during the second decade of life. Among intracranial teratomas, suprasellar germ cell tumors in particular are extremely rare. We present the case of an 18-year-old girl who underwent a successful endoscopic transnasal resection of a suprasellar teratoma with a mixed germ cell component. Case Description An 18-year-old girl presented with progressive visual disturbance, headache, weight loss, and fatigue for 2 weeks. She had decreased vision in her right eye and double vision when looking to the right side. On examination, she had right-side complete abducens nerve palsy and partial oculomotor nerve palsy bilaterally. Brain imaging revealed a large suprasellar lesion consistent with a germ cell tumor. The patient underwent a transnasal endoscopic resection of the lesion. Pathology showed a mixed germ cell tumor (80% mature cystic teratoma, 18% yolk sac tumor, and 2% germinoma). The mature teratomatous elements identified included skin with sebaceous material, hair, cartilage, acini, colonic mucosa, muscle, nerve bundles, and adipose tissue. Postoperative magnetic resonance imaging (MRI) showed residual tumor in the left cavernous sinus and anterior clinoid process superiorly. At a 1-year follow-up, the double vision had resolved, and her vision showed progressive improvement. The patient was maintained on treatment for diabetes insipidus, hypothyroidism, and adrenal insufficiency. Her last MRI showed no signs of tumor progression. Conclusions The present case demonstrates a safe endoscopic transnasal surgical resection of a rare suprasellar tumor, mixed teratoma, with intra-axial extension. The endoscopic transnasal approach can be considered a valid option for a suprasellar lesion.

scholarly journals Histopathological Study of Ovarian Tumors at a Tertiary Care Hospital of Central Nepal

2019 ◽  
Vol 15 (1) ◽  
pp. 22-29
Author(s):  
Binita Goyal ◽  
T Sheshagiri Rao ◽  
Himanshu Regmi
Keyword(s):  
Germ Cell ◽  
Size Range ◽  
Malignant Tumors ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Age Group ◽  
Stromal Tumors

Background: Ovarian tumors are histogenetically varied and complex tumors spanning all age groups. They account for 30% of all gynaecologic cancers. Malignant tumors carry a high mortality due to its late detection and ineffective screening programs. Current study aims at finding association between age at presentation and size of tumor with behavior of tumors and also association between category of tumor and age at presentation. Methods: This Hospital record based cross-sectional (historical) study was carried out on 158 cases of ovarian tumors received in Department of Pathology, College of Medical Sciences and Teaching Hospital during a time period of five and a half years from January 2012 to June 2017. Results: Age of the patients ranged from 12 to 88 years with maximum cases 96 (60.8%) in 20 – 40 years age group. The mean ±SD of age was 36.6±14.4 years. Majority of the cases 137 (86.7%) were benign. Sixteen (10.1%) cases were malignant and 5 (3.2%) cases were borderline. Majority of both benign and malignant cases were seen in 20 – 40 years age group. Size of the tumors ranged from 2 – 30 cm with mean±SD of 9.9±5.0 cm and maximum 93 (58.9%) cases in the size range of 5 – 10 cm. Majority of both benign and malignant tumors were in the size range of 5 – 10 cm. There was no association of age at presentation and size of tumor with behavior of tumor (p > 0.05). Sevety five (47.5%) cases were germ cell tumors, 72 (45.6%) cases were surface epithelial-stromal tumors, 9 (5.7%) cases were sex cord-stromal tumors, 1 (0.6%) was bilateral with surface epithelial tumor in right ovary and germ cell tumor in left ovary and 1 (0.6%) case was soft tissue tumor not specific to ovary. Majority of cases of germ cell tumors were seen below 40 years age whereas significant proportion of surface epithelial-stromal tumors was seen after 40 years with significant association between category and age at presentation (p < 0.05). Most common histopathological diagnosis overall was dermoid cyst in 43.7% cases. Conclusions: Benign ovarian tumors were more common than  malignant ones. Malignancy was seen in all age groups and in any size tumor. Surface epithelial-stromal   tumors and germ cell tumors were roughly equal in frequency with slight predominance of latter. Germ cell tumors were common in younger whereas surface epithelial-stromal tumors were more common in older   individuals. Histopathological examination in any ovarian tumor at any age with any size is mandatory.

scholarly journals Ovarian tumors in childhood and adolescents - Our eight years experiences

1970 ◽  
Vol 3 (1) ◽  
pp. 39-42
Author(s):  
Archana Amatya ◽  
Ashma Rana ◽  
Geeta Gurung
Keyword(s):  
Prospective Study ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
University Teaching ◽  
Emergency Unit ◽  
Different Types ◽  
A Prospective Study

Aims: To study the distribution of different types of ovarian tumors seen in adolescents and children and evaluate the commonest tumor during this period. Methods: A prospective study conducted at Dept of Ob/Gyn, Tribhuvan University Teaching Hospital form January 1999 - January 2008. Results: There were a total of 80 cases of ovarian tumors in childhood and adolescents. Most of the cases had presented to the outpatient department of Ob/Gyn (54%), Medicine (10%), Surgery (21%) and Emergency Unit (15%). Majority of the cases were between the ages of 15 to 19 and tumors in childhood age up to 14 represented 21% of the total ( < 10year being 4). The most frequently occurring tumor was Germ cell tumors accounting for 59 (73.7%) of the total. Out of which dermoid was the most frequently occurring in 45(76.2%). Nineteen (23.71 %) of the total tumor were malignant. All of them underwent laparatomy followed by enucleation (14); Unilateral ophoorectomy (28), unilateral salphingooophorectomy (36) and TAHBSO (2). Conclusion: This study shows the preponderance of germ cell tumor and high percentages of malignancies within germ cell tumor in young children and adolescents. Keywords: childhood, adolescent, ovarian tumors, malignancy   doi:10.3126/njog.v3i1.1438   NJOG 2008 May-June; 3(1): 39 - 42

Sign in / Sign up

Export Citation Format

Share Document