scholarly journals Histopathological Study of Ovarian Tumors at a Tertiary Care Hospital of Central Nepal

2019 ◽  
Vol 15 (1) ◽  
pp. 22-29
Author(s):  
Binita Goyal ◽  
T Sheshagiri Rao ◽  
Himanshu Regmi
Keyword(s):  
Germ Cell ◽  
Size Range ◽  
Malignant Tumors ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Age Group ◽  
Stromal Tumors

Background: Ovarian tumors are histogenetically varied and complex tumors spanning all age groups. They account for 30% of all gynaecologic cancers. Malignant tumors carry a high mortality due to its late detection and ineffective screening programs. Current study aims at finding association between age at presentation and size of tumor with behavior of tumors and also association between category of tumor and age at presentation. Methods: This Hospital record based cross-sectional (historical) study was carried out on 158 cases of ovarian tumors received in Department of Pathology, College of Medical Sciences and Teaching Hospital during a time period of five and a half years from January 2012 to June 2017. Results: Age of the patients ranged from 12 to 88 years with maximum cases 96 (60.8%) in 20 – 40 years age group. The mean ±SD of age was 36.6±14.4 years. Majority of the cases 137 (86.7%) were benign. Sixteen (10.1%) cases were malignant and 5 (3.2%) cases were borderline. Majority of both benign and malignant cases were seen in 20 – 40 years age group. Size of the tumors ranged from 2 – 30 cm with mean±SD of 9.9±5.0 cm and maximum 93 (58.9%) cases in the size range of 5 – 10 cm. Majority of both benign and malignant tumors were in the size range of 5 – 10 cm. There was no association of age at presentation and size of tumor with behavior of tumor (p > 0.05). Sevety five (47.5%) cases were germ cell tumors, 72 (45.6%) cases were surface epithelial-stromal tumors, 9 (5.7%) cases were sex cord-stromal tumors, 1 (0.6%) was bilateral with surface epithelial tumor in right ovary and germ cell tumor in left ovary and 1 (0.6%) case was soft tissue tumor not specific to ovary. Majority of cases of germ cell tumors were seen below 40 years age whereas significant proportion of surface epithelial-stromal tumors was seen after 40 years with significant association between category and age at presentation (p < 0.05). Most common histopathological diagnosis overall was dermoid cyst in 43.7% cases. Conclusions: Benign ovarian tumors were more common than  malignant ones. Malignancy was seen in all age groups and in any size tumor. Surface epithelial-stromal   tumors and germ cell tumors were roughly equal in frequency with slight predominance of latter. Germ cell tumors were common in younger whereas surface epithelial-stromal tumors were more common in older   individuals. Histopathological examination in any ovarian tumor at any age with any size is mandatory.

scholarly journals Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

2019 ◽  
Vol 11 (01) ◽  
pp. 075-081 ◽  
Author(s):  
Neha Gupta ◽  
Mahima Yadav ◽  
Vikas Gupta ◽  
Deepshikha Chaudhary ◽  
Shashikant C. U. Patne
Keyword(s):  
Germ Cell ◽  
Who Classification ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Germ Cell Tumors ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Care Hospital ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors

Abstract BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

scholarly journals Histopathological evaluation of ovarian tumours in southern part of Assam

2021 ◽  
Vol 9 (4) ◽  
pp. 1090
Author(s):  
Madhusmita Choudhury ◽  
Monoj K. Deka ◽  
Shah A. Sheikh
Keyword(s):  
Germ Cell ◽  
Malignant Tumors ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Reproductive Age ◽  
Histopathological Study ◽  
Age Group ◽  
Malignant Tumours ◽  
Morphological Pattern ◽  
Ovarian Tumours

Background: Ovarian malignancy is the second most common cancer of the female reproductive system and the leading cause of death from gynecologic malignancy. With increase in longevity, the incidence of epithelial ovarian cancer is increasing and its etiopathology remains unknown. A female’s risk at birth of having ovarian tumour sometime in her life is 6-7%. Two third of ovarian tumours occur in women of reproductive age group. The aim was to study the distribution of morphological pattern of benign, malignant, and nonneoplastic lesions of the ovary in different age groups and to determine the likelihood of bilateral involvement in different morphologic subtypes.Methods: A retrospective study from January 2018 to December 2020 was undertaken. A total of 210 surgical specimens were obtained. Detailed clinical information and radiological findings were recorded from the case sheets. Grossing of the surgical specimens was done in the pathology department, followed by histological examination.Results: Of 210 cases, benign cases were 140 (66.7%), malignant cases were 70 (33.3%). Surface epithelial tumors were most common (116/55.2%) followed by germ cell tumors (76, 36.1%) followed by others. Serous cystadenoma was commonest benign tumor (58, 41.4%). Serous adenocarinoma was commonest malignant tumor (19, 27.1%). Benign tumours were more common in the younger age group i.e. <40 years of age whereas malignant tumours were supervenes with increase in age. Most benign ovarian tumors (54, 38.6%) were seen between 31-40 years whereas most malignant tumors (24, 34.3%) were seen above 40 years. In 1st two decades, germ cell tumors were more common than other tumours.Conclusions: The prognosis and varying therapeutic strategies of ovarian tumours necessitate an accurate pathological evaluation. Histopathological study is still the gold standard in diagnosing most of these tumours. 

Histopathological profile of ovarian tumors in a tertiary care center- a descriptive study

2021 ◽  
Vol 9 (4) ◽  
pp. 1010
Author(s):  
Anitha Pallikkara V. ◽  
Shameem K. Ummer Ali
Keyword(s):  
Germ Cell ◽  
Malignant Tumors ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Medical College ◽  
Epithelial Tumors

Background: Ovarian neoplasms are a heterogeneous group of tumors with varied clinical, morphological and histological features. Ovarian cancer accounts for about 3% of all cancer in females and is the 5th most common cause of death due to cancer because most ovarian tumors spread beyond ovary by the time of diagnosis. The objective of the study was to document the histological pattern and prevalence of ovarian tumors in specimens received at department of pathology government medical college Alappuzha.Methods: This was a prospective study of 18 months duration which comprised of 245 cases of ovariectomy and ovariotomy specimens received in the department of pathology, govt. T.D medical college Alappuzha, Kerala. After detailed and thorough gross examination of the specimens, bits from representative areas were routinely processed and stained with H and E. Tumors were classified as per WHO classification. Appropriate immunohistochemical studies were performed wherever required.Results: Out of 245 cases studied, majority were benign tumors (78.36%), followed by malignant tumors (15. 11%). Borderline tumors comprised (6.53%) of the total cases. Age groups studied ranged from 11-70 years. Epithelial tumors were the most common (76.32%) followed by germ cell tumors (17.55%), sex cord stromal tumors (5.03%) and carcinoma arising in germ cell tumors (0.81%). Serous cystadenoma was found to be the commonest benign tumor and serous cystadenocarcinoma was the commonest malignant ovarian neoplasm.Conclusions: Surface epithelial tumors were the most common ovarian tumors. The maximum number of tumors were noted in the age group 21-40 years. Malignant tumors were common above 40 years. 

scholarly journals Ovarian Germ Cell Tumor – Histopathological and statistical analysis

2013 ◽  
Vol 3 (6) ◽  
pp. 441-446
Author(s):  
A Ghosh ◽  
D Magar Gharti ◽  
B Sathian ◽  
R Narasimhan ◽  
Op Talwar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Mature Cystic Teratoma ◽  
Age Group ◽  
Malignant Germ Cell Tumors

Background: Ovarian cancers are common among females. The ovarian tumors are classified according to its histogenesis. In the present study, we analyzed the germ cell ovarian tumors reported in our institute. Materials and Methods: This study was a hospital based retrospective study. All ovarian germ cell tumor reported from Jan 2001 to Feb 2013 were retrieved and analyzed. The specimens were routinely processed and the slides were stained with H&E and special stains wherever required. Results: A total of 340 cases of ovarian tumors were reported and 150 cases (44%) were of germ cell origin. We had 137 cases of benign and 13 cases of malignant germ cell tumors. Most common subtype was mature cystic teratoma comprising 125 cases. Among the malignant cases, the most common was immature teratoma (5 cases). Age range in our series was from 8 to 82 years (mean 28 years). The most common age group affected was 21-30 years. Most of the malignant cases (76.9%) were in less than 30 years. Among the malignant cases majority (84.6%) were more than 10 cm in size. None of the malignant germ cell tumors were bilateral. Conclusion: Among germ cell tumors of ovary, mature cystic teratoma is the most common tumor and malignant subtypes are uncommon. Malignant tumors tend to occur in younger age group. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8990 Journal of Pathology of Nepal (2013) Vol. 3, 441-446

scholarly journals Clinicopathological analysis of ovarian tumours: a 10 year retrospective study

2018 ◽  
Vol 7 (8) ◽  
pp. 3216
Author(s):  
Sahana N. Naik ◽  
Sunil Kumar K. S. ◽  
Girija B.
Keyword(s):  
Malignant Tumors ◽  
Female Genital Tract ◽  
Germ Cell Tumors ◽  
Mucinous Cystadenoma ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Age Group ◽  
Epithelial Tumors ◽  
Neoplastic Lesions

Background: Ovarian tumors account for 30% of all cancers of female genital tract which represents the sixth most common cancer and fourth leading cause of death in women. The present study was done with an objective to determine the frequency and distribution of various ovarian tumors and to study their clinical and histopathological presentations.Methods: It is a retrospective observational study of patients with ovarian tumors subjected to surgery in the department of obstetrics and gynecology, SDM College of Medical Sciences and Hospital from January 2005 to December 2015.Results: There were 642 cases comprising of 77.7% of neoplastic lesions and 22.3% of non-neoplastic lesions. Majority of the ovarian tumors (83%) were seen in the age group of 20 to 50 years. Mean age for ovarian tumors was 38 years.  Among the neoplastic lesions 84% were benign, 14.2% were malignant and 1.8% were borderline tumors. Surface epithelial tumors were the commonest tumors (60.9%) followed by germ cell tumors (12.8%).  Serous cystadenoma was the most common benign tumors (47.1%) followed by mucinous cystadenoma (18.4%). Among the ovarian malignant tumors; serous cystadenocarcinoma was the most common (4.5%) followed by mucinous cystadenocarcinoma (2.6%). Chocolate cysts were the most common among the non-neoplastic lesions (36.4%).Conclusions: Ovarian neoplastic lesions were more common than non-neoplastic lesions. Benign ovarian tumors were common in reproductive age group.  The mean age of occurrence for ovarian tumor was 38 years. The most common neoplasm was surface epithelial tumors, of which serous tumors was the commonest. Chocolate cysts were the most frequently encountered histopathological finding among the non-neoplastic lesions.

scholarly journals Retrospective study of tumor and tumor like conditions of ovary from a rural hospital in Kerala

2017 ◽  
Vol 6 (8) ◽  
pp. 3275 ◽  
Author(s):  
H. Valson ◽  
Satish Arakeri ◽  
Dally Maria Davis ◽  
Divya S.
Keyword(s):  
Germ Cell ◽  
Histopathological Examination ◽  
Wide Spectrum ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Ovarian Cysts ◽  
Histopathological Diagnosis ◽  
Emergency Setting ◽  
Reproductive Life ◽  
Mucinous Cyst

Background: Ovarian tumor and tumor like conditions are seen in women from early childhood to post-menopausal age. The ovaries are a pair of female sex glands responsible for the germ cell maturation, storage and release; cyclically. It also plays an important role in steroidogenesis. The ovaries are a totipotential structure and hence, neoplasms from all 3 germinal layers can be seen arising from it and manifesting clinically as ovarian tumors and tumor like conditions with its occurrence more during the late reproductive life. Ovarian tumors represent about 30% of all cancers of the female genital system. They manifesting in a wide spectrum of clinical, morphological and histological features.Methods: This is retrospective observational study where analysis of all cases which were encountered surgically during the period Mar 2012 to Mar 2017. The cases diagnosed as ovarian tumors were subjected to thorough investigation by CA125, ultrasound (USG) abdomen and pelvis and Computerised Tomography (CT) scan. Emergency presentations with twisted cysts were operated in emergency setting and histopathological examination (HPE) done to identify the nature of tumor. IHC was done wherever necessary to sub classify and confirm the histological diagnosis. Surgeries were done either by conventional laparotomy or by laparoscopy.Results: We have analyzed 175 cases retrospectively after histopathological diagnosis. The commonest lesions were ovarian cysts, out of which 63 cases (36%) were simple serous cyst adenomas followed by mucinous cyst adenomas 30 cases (17.14%). Germ cell tumors with struma ovarii were 34 cases (19.42%). The interesting part of the study was that we had a very high incidence of large endometriomas diagnosed as ovarian cysts before surgery 16 cases (9.4%). Two cases (1.14%) of ovarian malignancy were detected.Conclusions: The above study has revealed a spectrum of ovarian tumors over a wide age range from adolescent to late reproductive to menopausal and late menopausal age group. The incidence of malignancy was (1.14%).

scholarly journals Histopathological diagnosis of ovarian mass

2018 ◽  
Vol 8 (1) ◽  
pp. 1261-1264
Author(s):  
Shahali Shadab ◽  
Tadayon Tadayon
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Hospital Data ◽  
Ovarian Masses

Background:  Ovarian cysts are common forms of gynecological problems that can be range from physiological cysts to highly aggressive neoplastic lesions. The purpose of this study was to investigate prevalence and frequency of different histopathological patterns of ovarian lesions and their correlation with various parameters in Ahvaz, Iran.Materials and Methods: This is the retrospective study of patients with the ovarian masses at Ahvaz Imam Khomeini Hospital from 2010 - 2015. The relevant clinical details about the patient were retrieved from hospital data. Clinical characteristics of patients such as patient's age, presenting signs and symptoms, histopathological diagnosis, mass type, mass subtype, size of cysts and ovary which is involved were noted. Results: Two hundred sixty seven specimens of ovarian tumor obtained for histopathological examination. Of these, 163(61.0%) were tumor like, 96(36.0%) were benign tumor and 8(3.0%) were malignant. The most common tumor like conditions was Corpus luteum cyst (43.4% cases), among benign and malignant tumors, mature cystic teratoma (17.2% of total) and Epithelial tumors (n=4) were most common. There is a statistically significant positive relation between age and various ovarian masses. (P= 0.002). Histopathological diagnosis wasn't correlated with ovarian involvement.Conclusion: Benign tumors are more common than malignant tumors in all age groups. Germ cell tumors followed by surface epithelial cell tumors are the commonest tumor. Mature cystic teratoma was the most common tumor. Unilaterality is more frequently seen in ovarian tumors and various tumors are seen in various age groups.

scholarly journals Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers

2020 ◽  
Vol 42 (09) ◽  
pp. 555-561
Author(s):  
Tiago Augusto Gomes ◽  
Elizabeth Aparecida Campos ◽  
Adriana Yoshida ◽  
Luís Otavio Sarian ◽  
Liliana Aparecida Lucci de Angelo Andrade ◽  
...  
Keyword(s):  
Germ Cell ◽  
Clinical Features ◽  
Germ Cell Tumors ◽  
Serum Levels ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Stromal Tumors ◽  
Fertility Sparing ◽  
Sex Cord Stromal Tumors ◽  
Sex Cord Stromal Tumor

Abstract Objective To evaluate the role of clinical features and preoperative measurement of cancer antigen 125 (CA125), human epididymis protein (HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian tumors. Methods One hundred and nineteen consecutive women with germ cell, sex cord-stromal, and ovarian leiomyomas were included in this study. The preoperative levels of biomarkers were measured, and then surgery and histopathological analysis were performed. Information about the treatment and disease recurrence were obtained from the medical files of patients. Results Our sample included 71 women with germ cell tumors (64 benign and 7 malignant), 46 with sex cord-stromal tumors (32 benign and 14 malignant), and 2 with ovarian leiomyomas. Among benign germ cell tumors, 63 were mature teratomas, and, among malignant, four were immature teratomas. The most common tumors in the sex cord-stromal group were fibromas (benign) and granulosa cell tumor (malignant). The biomarker serum levels were not different among benign and malignant non-epithelial ovarian tumors. Fertility-sparing surgeries were performed in 5 (71.4%) women with malignant germ cell tumor. Eleven (78.6%) patients with malignant sex cord-stromal tumors were treated with fertility-sparing surgeries. Five women (71.4%) with germ cell tumors and only 1 (7.1%) with sex cord-stromal tumor were treated with chemotherapy. One woman with germ cell tumor recurred and died of the disease and one woman with sex cord-stromal tumor recurred. Conclusion Non-epithelial ovarian tumors were benign in the majority of cases, and the malignant cases were diagnosed at initial stages with good prognosis. The measurements of CA125, HE4, and CEA serum levels were not useful in the preoperative diagnosis of these tumors.

scholarly journals Extragonadal Germ Cell Tumors in Children and Adolescents - a 20 Year Study

2020 ◽  
Vol 27 (4) ◽  
pp. 281-287
Author(s):  
Felice FAIZAL ◽  
Alka KALGUTKAR ◽  
Vandana DAHAKE
Keyword(s):  
Germ Cell ◽  
Treatment Options ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Response To Treatment ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Sacrococcygeal Region ◽  
Extragonadal Germ Cell Tumors

Germ cell tumors (GCT) are rare neoplasms which are seen in all age groups and both sexes. Gcts in the pediatric age group show considerable variation from their adult counterparts in relation to site, histological type, clinical and radiological features and response to treatment. Extragonadal gcts are much more common in the pediatric age group with the most common sites being sacrococcygeal region, head and neck, retroperitoneum and mediastinum. Unusual sites like the vagina and urinary bladder have also been reported. Therefore, the varied presentations and different treatment options should be considered.

Sign in / Sign up

Export Citation Format

Share Document