scholarly journals BK Virus Associated Nephropathy, a Cause of Early Renal Allograft Dysfunction: A Single Centre Study

2017 ◽  
Vol 13 (2) ◽  
pp. 140-145
Author(s):  
S. Shrestha ◽  
P.G. Kerr ◽  
J. Kanellis ◽  
K.R. Polkinghorne ◽  
F. Brown ◽  
...  
Keyword(s):  
Renal Transplant ◽  
De Novo ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Graft Dysfunction ◽  
Early Graft ◽  
The Mean ◽  
The Difference ◽  
Early Graft Dysfunction

Background BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia.Method A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glomerular filtration rate (eGFR) was compared at baseline, at BKVN diagnosis and 3 and 12 months post-diagnosis.Result Of the 317 de novo renal transplants recipients in the study period, 20 (6.3%) developed BKVN. The mean age was 54.8 ± 13.1 years and 13 (65%) were male. The mean time from transplant to BKVN was 8.7 ± 6.7 months with 17 (85%) diagnosed within 12 months. Four recipients each were diagnosed BKVN on 3 and 12 month surveillance biopsy. Six (30%) had normal eGFR at diagnosis. Mean eGFR at diagnosis was 38.8 ± 19.2 ml/min/1.73 m2, which was significantly lower (p < 0.01) than that at baseline (50.3 ± 16.4 ml/min/1.73 m2). eGFR improved numerically at 3 and 12 months post-diagnosis, however the difference was not significant. One patient had graft failure, 19 months after diagnosis.Conclusion BKVN generally occurs in first post-transplant year and is an important cause of early graft dysfunction. Surveillance biopsy helps in detecting subclinical BKVN.

Does Reduction in Immunosuppression in Viremic Patients Prevent BK Virus Nephropathy in De Novo Renal Transplant Recipients? A Prospective Study

2008 ◽  
Vol 85 (8) ◽  
pp. 1099-1104 ◽  
Author(s):  
Cyrielle Alméras ◽  
Vincent Foulongne ◽  
Valérie Garrigue ◽  
Ilan Szwarc ◽  
Fernando Vetromile ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Prospective Study ◽  
De Novo ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Virus Nephropathy ◽  
A Prospective Study

scholarly journals Radical prostatectomy outcomes in renal transplant recipients: a retrospective case series of Thai patients

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kun Sirisopana ◽  
Pocharapong Jenjitranant ◽  
Premsant Sangkum ◽  
Kittinut Kijvikai ◽  
Suthep Pacharatakul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Renal Transplant ◽  
Operative Time ◽  
Case Series ◽  
Urinary Continence ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Estimated Blood Loss ◽  
The Mean

Abstract Background The incidence of prostate cancer in renal transplant recipients (RTR) is similar to the general population. Radical prostatectomy (RP) is the standard of care in the management of clinically localized cancer, but is considered complicated due to the presence of adhesions, and the location of transplanted ureter/kidney. To date, a few case series or studies on RP in RTR have been published, especially in Asian patients. This study aimed to evaluate the efficacy and safety and report the experience with RP on RTR. Methods We retrospectively reviewed data of 1270 patients who underwent RP from January 2008 to March 2020, of which 5 patients were RTR. All available baseline characteristics, perioperative and postoperative data (operative time, estimated blood loss (EBL), complications, length of hospital stay, complication), pathological stage, Gleason score, surgical margin status, and pre/postoperative creatinine were reviewed. Results Of the 5 RTR who underwent RPs (1 open radical prostatectomy (ORP), 1 laparoscopic radical prostatectomy (LRP), 2 robotic-assisted laparoscopic radical prostatectomies (RALRP), and 1 Retzius-sparing RALRP (RS-RALRP)) prostatectomy, the mean age (± SD) was 70 (± 5.62) years. In LRP and RALRP cases, the standard ports were moved slightly medially to prevent graft injury. The mean operative time ranged from 190 to 365 min. The longest operative time and highest EBL (630 ml) was the ORP case due to severe adhesion in Retzius space. For LRP and RALRP cases, the operative times seemed comparable and had EBL of ≤ 300 ml. All RPs were successful without any major intra-operative complication. There was no significant change in graft function. The restorations of urinary continence were within 1 month in RS-RALRP, approximately 6 months in RALRP, and about 1 year in ORP and LRP. Three patients with positive surgical margins had prostate-specific antigen (PSA) persistence at the first follow-up and 1 had later PSA recurrence. Two patients with negative margins were free from biochemical recurrence at 47 and 3 months after their RP. Conclusions Our series suggested that all RP techniques are safe and feasible mode of treatment for localized prostate cancer in RTR.

Everolimus Conversion to Treat BK Virus Infection in Renal Transplant Recipients: Interim Analysis of a Pilot Study.

2014 ◽  
Vol 98 ◽  
pp. 558-559 ◽  
Author(s):  
D. Wojciechowski ◽  
A. Webber ◽  
S. Chandran ◽  
R. Hirose ◽  
F. Vincenti
Keyword(s):  
Pilot Study ◽  
Renal Transplant ◽  
Virus Infection ◽  
Interim Analysis ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Evolution of the absorption profile of cyclosporine A in renal transplant recipients: a longitudinal study of the de novo and maintenance phases

2005 ◽  
Vol 21 (1) ◽  
pp. 197-202 ◽  
Author(s):  
Matthias Büchler ◽  
Steve Chadban ◽  
Edward Cole ◽  
Karsten Midtvedt ◽  
Eric Thervet ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Renal Transplant ◽  
Cyclosporine A ◽  
De Novo ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Absorption Profile

scholarly journals 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients

2007 ◽  
Vol 20 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Helio Tedesco-Silva ◽  
Stefan Vitko ◽  
Julio Pascual ◽  
Josette Eris ◽  
John C. Magee ◽  
...  
Keyword(s):  
Renal Transplant ◽  
De Novo ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Safety And Efficacy

scholarly journals BK Virus-Specific Antibodies and BKV DNA in Renal Transplant Recipients with BKV Nephritis

2005 ◽  
Vol 5 (11) ◽  
pp. 2719-2724 ◽  
Author(s):  
Sundaram Hariharan ◽  
Eric P. Cohen ◽  
Brahm Vasudev ◽  
Rimas Orentas ◽  
Raphael P. Viscidi ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Specific Antibodies

BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation

2017 ◽  
Vol 96 ◽  
pp. 7-11 ◽  
Author(s):  
Mohammad Shenagari ◽  
Ali Monfared ◽  
Hadise Eghtedari ◽  
Aydin Pourkazemi ◽  
Tolou Hasandokht ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Virus Replication ◽  
Potential Risk ◽  
Bk Virus ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Potential Risk Factors
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