scholarly journals Giant Abdominal Mass: Papillary Renal Cell Carcinoma with Metastases to the Bladder, Omentum and Perigastric Tissue

2020 ◽  
pp. 1-4
Author(s):  
Miguel A. M. Pereira ◽  
Hye Chung Kang ◽  
Lucas Natã Lessa Silva ◽  
Miguel A. M. Pereira ◽  
Rafael Catelli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Papillary Renal Cell Carcinoma ◽  
Large Mass ◽  
Multiple Metastases ◽  
The Right

Papillary renal cell carcinoma is an uncommon malignant tumor, which rarely metastases to the bladder and/or omentum. We report the case of a 71-year-old woman with macrohematuria for two years and a large mass on the right flank. Thus, we present a brief review of the literature regarding the classification, clinical manifestations, diagnosis, immunohistochemical profile, and treatment of this neoplasm. Special attention was given to the role of immunohistochemistry, which was decisive for the determination of multiple metastases, as well as the study by imaging exams, which defined the best surgical approach.

scholarly journals Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Abelardo Loya-Solis ◽  
Lucía Alemán-Meza ◽  
Luis Carlos Canales-Martínez ◽  
Rodolfo Franco-Márquez ◽  
Alim Adriana Rincón-Bahena ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Horseshoe Kidney ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Tumors ◽  
Eosinophilic Cytoplasm ◽  
Abundant Eosinophilic Cytoplasm ◽  
History Of ◽  
The Right

Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free.

scholarly journals Atypical Presentation of Renal Cell Carcinoma: A Case Report

2021 ◽  
Vol 3 (1) ◽  
pp. 8-10
Author(s):  
Sadia Saber ◽  
Paritosh Kumar Ghosh ◽  
Mohammed Tarek Alam ◽  
Naz Yasmin ◽  
Mohammad Monower Hossain ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Renal Tumors ◽  
Diverse Range ◽  
Renal Tumours ◽  
Gi Symptoms ◽  
Classical Triad

The most common form of malignant renal tumours is Renal cell carcinoma (RCC) which is considered for nearly 80-85% of primary renal tumors. Now a day renal tumours can usually be detected at primary stage due to the popularity of sonography. Clinical manifestations of RCC have a diverse range. Loin pain, hematuria and abdominal mass contemplate as a classical triad but only present in 4–17% of cases. Here, we present a unique case of RCC in a 65 years old elderly gentleman admitted to our hospital with upper gastrointestinal (GI) symptoms without any significant GI involvement.

scholarly journals Ipsilateral Synchronous Papillary and Clear Cell Renal Cell Carcinoma: a Case Report and Literature Review

2021 ◽  
Author(s):  
Jing Yin ◽  
Baojiang Li ◽  
Mo Zheng
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clinical Manifestations ◽  
Rare Condition ◽  
Papillary Renal Cell Carcinoma ◽  
Cell Renal Cell Carcinoma ◽  
Precise Diagnosis ◽  
Single Mass

Abstract Background: The rare disease of ipsilateral synchronous papillary and clear cell renal cell carcinoma was often misdiagnosed as a single tumor with intra-renal metastasis or some other diseases preoperatively. Both of the effective management and long overall survival might be affected as the different prognosis of the two kinds of tumors. Here, we report a case of ipsilateral synchronous papillary and clear cell renal cell carcinoma, and present the clinicopathological features as well as review the literature in China.Case presentation: A 70-year-old man presented with a single mass in the left renal revealed either by ultrasound or CT during a routine physical examination. The tumor was occurred as two isolated masses in the gross finding. Hematoxylin and eosin staining and immunohistochemistry were performed. Papillary cell carcinoma and clear cell renal cell carcinoma were the compositions of the tumors. Immunostainings were as follows: The papillary renal cell carcinoma showed positive for CK7, P504s, Pax8,Vimentin, and scatterly for CD10, the proliferation rates of Ki67 was just 3%; While the clear cell renal cell carcinoma was positive for Pax8,CAIX,Vimentin, and diffusely for CD10, but negative for CK7 and P504s, the Ki67 proliferation rates was 5%. The patient was diagnosed with ipsilateral synchronous papillary and clear cell renal cell carcinoma, and free from the disease 9 months after surgery.Conclusions: Ipsilateral synchronous papillary and clear cell renal cell carcinoma is a rare condition without specific clinical manifestations. The understanding of the computed tomography features and increasing the awareness or experience of the disease may be helpful to improve the preoperative diagnosis accuracy. Precise diagnosis should be based on histopathological morphology and immunostaining. As the different prognosis of the two tumors, optimal surgical treatment should be performed to prolong the survival time.

Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

2017 ◽  
Vol 25 (8) ◽  
pp. 745-750 ◽  
Author(s):  
John James Aird ◽  
Aisling U. Nic an Riogh ◽  
Stewart Fleming ◽  
R. Gordon Hislop ◽  
Paul Sweeney ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Molecular Genetic ◽  
Papillary Renal Cell Carcinoma ◽  
Molecular Genetic Analysis ◽  
First Case ◽  
Papillary Rcc ◽  
The Right ◽  
Tomography Scan

Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC). In rare cases, heterologous differentiation has been described. We present a case of heterologous osteosarcomatous differentiation in association with sarcomatoid papillary RCC including an analysis of chromosomal copy number alteration. This is the first case to identify heterologous differentiation in association with papillary RCC. The patient was a 70-year-old man who had a mass in the right kidney. Speckled calcification was seen on computed tomography scan. Histological assessment demonstrated papillary RCC merging with areas of sarcomatoid change and malignant bone formation simulating osteosarcoma. Cytogenetic evaluation demonstrated additional copies of chromosome 7 in both epithelial and osteosarcomatous components. A literature review identified 33 previous cases of heterologous differentiation in association with RCC. Of the 14 cases that reported an epithelial subtype, 13 cases were reported to be chromophobe RCC and 1 case was reported to be clear cell RCC.

Clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma: two case reports and literature review

2020 ◽  
Author(s):  
Dalin Feng ◽  
Mingshuai Wang ◽  
Xiaodong Zhang ◽  
Jianwen Wang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Female Patient ◽  
Male Patient ◽  
Renal Cell ◽  
Clinical Characteristics ◽  
Genetic Test ◽  
Enhanced Ct ◽  
The Right ◽  
Hereditary Leiomyomatosis

Abstract Background The objective of this study is to discuss clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma on the basis of 2 cases and to review recent literature, in order to present medical advances. Methods A 29-year old male patient came to our hospital because of a huge tumour on the right kidney. Enhanced CT showed that the tumour was about 15.5*10.5 cm, and was considered to be malignant. Another case was a 38-year old female patient. She complained was found to have a right kidney tumour in a routine physical examination. Enhanced CT showed an early-stage tumour of about 4.3*3.7 cm on the lower pole of the right kidney. The male patient underwent open radical nephrectomy and the female patient underwent laparoscopic radical nephrectomy and extensive retroperitoneal lymph node dissection. The two patients underwent genetic testing and were diagnosed as having hereditary leiomyomatosis with renal cell carcinoma. Results The postoperative pathology in both patients revealed type 2 papillary renal cell carcinoma but with different prognosis. The male patient suffered multiple metastasis 10 months post-operation. The metastatic tumour of the abdominal wall was resected to confirm recurrence and hereditary leiomyomatosis renal cell carcinoma was diagnosed by the genetic test. While the female patient had a specific family history and uterine leiomyomas, the genetic test helped us to identify hereditary leiomyomatosis renal cell carcinoma pre-operation. Because of the early diagnosis and timely treatment, the female patient was considered to have a good prognosis. Conclusion Hereditary leiomyomatosis renal cell carcinoma is a rare hereditary disease resulting from FH gene mutation. There are currently no effective treatments.Our cases demonstrate that hereditary leiomyomatosis renal cell carcinoma is a very aggressive disease. Early screening and surveillance are recommended for patients with a family history or who are at risk of hereditary leiomyomatosis renal cell carcinoma. Surgical and palliative therapy still play an important role in clinical treatment.

scholarly journals Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines

2021 ◽  
Author(s):  
Youfeng Yang ◽  
Christopher J. Ricketts ◽  
Cathy D. Vocke ◽  
J. Keith Killian ◽  
Hesed M. Padilla‐Nash ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell ◽  
Carcinoma Cell Lines
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