scholarly journals Iatrogenic Laryngeal Lipoma: Rare Complication after Fat Injection Due to Increased Vocal Fold

2021 ◽  
pp. 1-3
Author(s):  
Fabrizia Elli ◽  
Fabrizia Elli ◽  
Marco Stacchini ◽  
Roberta Priola ◽  
Alberto Daniele Arosio ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Vocal Fold ◽  
Rare Case ◽  
Rare Complication ◽  
Fat Injection ◽  
Vocal Cords ◽  
Autologous Fat ◽  
Minimal Morbidity ◽  
Glottic Closure

Centrifuged autologous fat injection is a safe, feasible and effective phonosurgical technique for the treatment of chordal paralysis and its use dates back to 1991. This procedure allows to correct glottic incompetence by medialization of one or both vocal cords. Expecting fat resorption, which occurs postoperatively, the surgeon injects at least 30-40% more fat than needed to achieve glottic closure. The procedure is minimally invasive, with minimal morbidity and complications. In this article, we present a rare case of iatrogenic lipoma secondary to excessive lipoinjection due to the increase of the vocal cords, causing severe dysphonia.

Autologous Fat Injection for Vocal Fold Paralysis: Long-Term Histologic Evaluation

1995 ◽  
Vol 104 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Lauren S. Zaretsky ◽  
Michael deTar ◽  
Maisie L. Shindo ◽  
Dale H. Rice
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Laryngeal Nerve ◽  
Fat Injection ◽  
Autologous Fat ◽  
Alloplastic Materials ◽  
Histologic Evaluation ◽  
Left Recurrent Laryngeal Nerve ◽  
Thyroarytenoid Muscle

Many techniques have been developed for medialization of the paralyzed vocal fold. The purpose of this study is to evaluate autologous fat as an alternative to alloplastic substances for use in vocal fold medialization. Eight dogs underwent left recurrent laryngeal nerve sectioning. Autologous fat was harvested, and the paralyzed vocal fold was medialized by injecting the fat into the thyroarytenoid muscle. The animals were divided into three groups for evaluation at 1, 3, and 6 months. Videolaryngoscopy was performed prior to sacrificing the animals. The larynges were sectioned coronally, and histologic studies were performed. The studies confirmed the preservation of viable fat at the injected site in all animals. Only a minimal inflammatory response was observed in the 1-month group. It would appear that fat injection is a viable alternative to Teflon injection and thyroplasty; it eliminates the need for alloplastic materials, does not appear to migrate, and does not require an open procedure.

Long-term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy

2005 ◽  
Vol 132 (5) ◽  
pp. 685-688 ◽  
Author(s):  
Hisanori Sasai ◽  
Yusuke Watanabe ◽  
Hiroshi Muta ◽  
Junichi Yoshida ◽  
Ibuki Hayashi ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Folds ◽  
Vocal Fold Paralysis ◽  
Histological Evaluation ◽  
Fat Injection ◽  
Special Equipment ◽  
Autologous Fat ◽  
Vocal Fold Augmentation ◽  
Disposable Needle

OBJECTIVE: To histologically evaluate the long-term outcomes of autologous fat grafts after injection laryngoplasty in the human larynx. STUDY DESIGN AND SETTING: We injected liposuctioned fat for vocal fold augmentation in patients with vocal fold paralysis. We suctioned autologous fat from the low abdomen with an 18-G disposable needle and a 20-mL disposable syringe under negative pressure. This is different from the conventional liposuction technique and avoids the use of special equipment. In this article, we report the histological evaluation of 2 patients (patient 1: 12 months, patient 2: 41 months) who required total laryngectomy after autologous fat injection into the vocal folds. RESULTS: Histological examination revealed normal-appearing viable adipocytes with minimal inflammatory response in both patients. CONCLUSIONS: Our liposuctioned autologous fat injection histologically offered long-term improvement in patients with impaired glottal closure from vocal fold paralysis. (Otolaryngol Head Neck Surg 2005;132:685-688.)

Efficacy of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor in a canine model

2009 ◽  
Vol 123 (S31) ◽  
pp. 24-29 ◽  
Author(s):  
H Umeno ◽  
S Chitose ◽  
Y Murofushi ◽  
K Kosai ◽  
K Sato ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Adenoviral Vector ◽  
Vocal Fold ◽  
Injection Laryngoplasty ◽  
Fat Tissue ◽  
Fat Injection ◽  
Autologous Fat ◽  
Hepatocyte Growth

AbstractObjective:The effectiveness of autologous fat injection laryngoplasty may be reduced by resorption of injected fat tissue. The aim of the present study was to clarify the efficacy of fat injection laryngoplasty using autologous fat plus a replication-defective adenoviral vector expressing hepatocyte growth factor, regarding reduction of injected fat tissue resorption.Material and methods:Four female beagle dogs were used in this study. After sedation, a direct laryngoscope was introduced to enable visualisation of the larynx. In each dog, harvested autologous fat plus an adenoviral vector expressing hepatocyte growth factor was injected into the right true vocal fold, and harvested fat plus an adenoviral vector expressing no gene was injected into the left true vocal fold. A total laryngectomy was performed one year after the intracordal fat injection. Coronal sections of the resected whole larynges were made and the following parameters assessed using light and electron microscopy: size of fat area; number of vasculoendothelial cells surrounding adipocytes; and shape of injected adipocytes in the vocal fold.Results:The fat area was significantly larger and the number of vasculoendothelial cells surrounding adipocytes significantly greater in the intracordal fat injection containing adenoviral vector expressing hepatocyte growth factor, compared with the control intracordal fat injection containing adenoviral vector expressing no gene. When viewed under electron microscopy, the injected adipocytes were observed to have grafted better in the intracordal fat injection with hepatocyte growth factor adenoviral vector, compared with the control intracordal fat injection with adenoviral vector expressing no gene.Conclusions:Injection into the vocal fold of autologous fat containing an adenoviral vector expressing hepatocyte growth factor can reduce subsequent resorption of injected fat.

scholarly journals Computed tomographic assessment of autologous fat injection augmentation for vocal fold paralysis

2017 ◽  
Vol 2 (6) ◽  
pp. 459-465 ◽  
Author(s):  
Naoki Nishio ◽  
Yasushi Fujimoto ◽  
Mariko Hiramatsu ◽  
Takashi Maruo ◽  
Kenji Suga ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Fat Injection ◽  
Autologous Fat ◽  
Computed Tomographic

Comparative study of framework surgery and fat injection laryngoplasty

2009 ◽  
Vol 123 (S31) ◽  
pp. 35-41 ◽  
Author(s):  
H Umeno ◽  
S Chitose ◽  
K Sato ◽  
T Nakashima
Keyword(s):  
Comparative Study ◽  
Vocal Fold ◽  
Acoustic Analysis ◽  
Functional Results ◽  
Vocal Fold Paralysis ◽  
Injection Laryngoplasty ◽  
Unilateral Vocal Fold Paralysis ◽  
Fat Injection ◽  
Autologous Fat ◽  
Before And After

AbstractObjective:To evaluate differences between the functional results of framework surgery and autologous fat injection laryngoplasty, for patients with unilateral vocal fold paralysis.Study design:Sixty-two patients underwent framework surgery, while 64 received autologous fat injection laryngoplasty. Voice function before and after both procedures was assessed using aerodynamic and acoustic analysis, with differences evaluated using paired t-test in both groups.Results:In both groups, all parameters improved significantly after surgery, compared with before surgery. Post-operative improvement in all parameters was significantly greater after fat injection laryngoplasty, compared with framework surgery.Conclusion:Autologous fat injection laryngoplasty was thus found to be a more effective and reliable therapy for improving voice function in patients with vocal fold paralysis, compared with framework surgery.

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