OCR002-SP103 - Oral Immediate Release Study

Platelets play an important role in hemostasis during tissue injury, which blocks the defect and terminates blood loss. Platelet aggregation inhibitors are widely used in treatment of cardiovascular disorders and Peripheral arterial disease. Clopidogrel bisulphate and Cilostazol, are FDA approved BCS class II drugs, used in treatment of Platelet aggregation, peripheral arterial disease and intermittent claudication. The aim of the present study was to develop an immediate release pellets for combination of Clopidogrel bisulphate and Cilostazol using extrusion spheronization technique. The effects of spheronization speed(X1) and binder concentration (PVP K30) (X2), on size of pellets, disintegration time and drug release were studied using 32 full factorial design. The surface response and counter plot were drawn to facilitate an understanding of the contribution of the variables and their interaction. From the results, speed of spheronization of 1100 rpm and 5% concentration of PVP K30, were selected. In vitro drug release studies revealed more than 80% of clopidogrel bisulphate release and more than 75% of cilostazol release within 30 min of dissolution which complied with the pharmacopoeal limits. Film coated pellets did not show significant change in the drug release. DSC and FTIR studies revealed no interaction of drugs and excipient during pellet formulation. The pellet formulations of clopidogrel and cilostazol were found to be stable when stored at 40ºC±2ºC/ 75%RH±5%RH for 2 months. Conclusively, clopidogrel bisulphate and cilostazol pellet fixed dose combination could be successfully developed by design of experimentation and complied with pharmacopoeal limits.

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Regional In Vivo Dissolution of Immediate Release Ibuprofen in Human Gastrointestinal Tract and Its Relationship to Luminal pH, GI Motility, and Systemic Absorption

10.26226/morressier.57d6b2bbd462b8028d88ea1c ◽

2016 ◽

Author(s):

Mark Koenigsknecht

Keyword(s):

Gastrointestinal Tract ◽

Immediate Release ◽

Systemic Absorption ◽

Human Gastrointestinal Tract ◽

Luminal Ph ◽

Gi Motility ◽

In Vivo Dissolution

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Food Effect on Immediate Release Abuse Deterrent Opioids: Suggestions for Comparative Bioavailability/Bioequivalence Regulatory Requirements

10.26226/morressier.57d6b2bbd462b8028d88def0 ◽

2016 ◽

Author(s):

Loan Pham

Keyword(s):

Food Effect ◽

Immediate Release ◽

Regulatory Requirements ◽

Comparative Bioavailability

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In vivo and in vitro characterization of immediate release dosage forms containing n-acetylcysteine using the dynamic open flow-through test apparatus

10.26226/morressier.57d6b2b7d462b8028d88dd29 ◽

2016 ◽

Author(s):

Maximilian Sager

Keyword(s):

Immediate Release ◽

Dosage Forms ◽

Test Apparatus ◽

Open Flow ◽

In Vitro Characterization ◽

Flow Through

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MELATONIN METABOLITE; N1-ACETYL-N2-FORMYL-5-METHOXYKYNURAMINE STIMULATES PANCREATIC ENZYME SECRETION VIA CCK RELEASE. STUDY ON THE RATS.

10.26226/morressier.59a6b342d462b80290b53f8f ◽

2017 ◽

Author(s):

Jolanta Maria Jaworek

Keyword(s):

Pancreatic Enzyme ◽

Enzyme Secretion ◽

Pancreatic Enzyme Secretion ◽

Release Study ◽

Cck Release

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Knowledge, Perceptions and Practices on Modified Release Tablets among Prescribers: A Preliminary Study

Journal of Health Sciences and Innovative Research ◽

10.31357/jhsir.v1i01.4769 ◽

2020 ◽

Vol 01 (01) ◽

pp. 05-14

Author(s):

M.G.K.M. Fernando ◽

K.I.J. Priyadarshi ◽

L.G.T. Shanika ◽

N.R. Samaranayake

Keyword(s):

Online Survey ◽

Product Information ◽

Response Rate ◽

Immediate Release ◽

State Universities ◽

Modified Release ◽

Validated Questionnaire ◽

Therapeutic Outcomes ◽

Medical Faculties ◽

Enteric Coated

Introduction: Modified release tablets (MRTs) are developed to achieve different therapeutic outcomes and are frequently prescribed. This study aims to evaluate the knowledge, perceptions and practices on using MRTs among a selected cohort of prescribers. Methods: A self administered online survey was conducted using a pre-validated questionnaire, prepared in-house to assess knowledge, perceptions and practices on using MRTs, among academics with an MBBS degree in medical faculties of State universities in Sri Lanka. Results: The response rate was 15.5% among 375 prescribers. Most were females (53.4%) and were 46-55 years (29.3%). Over 50% correctly expanded abbreviations related to MRTs. Most defined enteric coated (87.9%) and targeted release (77.6%) forms accurately. However, 87.0% mixed-up definitions of sustained release with controlled release. Most believed that inability to split tablets (70.7%) and high cost (70.7%), as disadvantages of MRTs. Nearly half did not identify the risk of dose dumping (53.5%) and inflexible dosing schedule (44.8%) as disadvantages. For frequency of administering MRTs, 86.2% referred the product information leaflet (PIL) while 29.0% depended on the frequency of the corresponding immediate release tablet. Most (79.3%) prescribed MRTs to increase patient compliance while 12.1% prescribed them to reduce cost. When problems regarding MRTs were encountered, most referred PILs (81.0%) and clarified with experts (75.9%). Conclusions: Although the response rate was low, a clear gap in knowledge, perceptions and practices on using MRTs were identified among prescribers who responded. Interventions are needed to improve the knowledge, perceptions, and practices on using MRTs among prescribers.

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