Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage

2020 ◽  
Author(s):  
Keyword(s):  
Cognitive Function ◽  
Brain Damage ◽  
Frontal Brain

scholarly journals Effects of sulforaphane on cognitive function in patients with frontal brain damage: study protocol for a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e037543
Author(s):  
Fangkun Liu ◽  
Jing Huang ◽  
Gangrui Hei ◽  
Renrong Wu ◽  
Zhixiong Liu
Keyword(s):  
Cognitive Function ◽  
Gut Microbiota ◽  
Brain Damage ◽  
Study Protocol ◽  
Brain Tumours ◽  
Brain Trauma ◽  
Controlled Clinical Trial ◽  
Frontal Brain ◽  
Randomised Controlled ◽  
The Brain

IntroductionMany patients with frontal brain damage show serious cognitive function deficits, which hamper their quality of life and result in poor clinical outcomes. Preclinical research has shown that sulforaphane can significantly improve spatial localisation and working memory impairment after brain injury. The primary aim of this double-blind randomised controlled clinical trial is to assess the efficacy of sulforaphane for improving cognitive function in patients with frontal brain damage.Methods and analysisNinety eligible patients will be randomly allocated to an active treatment or a placebo group in a 2:1 ratio. Participants will undergo a series of cognitive and neuropsychiatric tests at baseline (week 0) and after 12 weeks to determine the effect of sulforaphane on cognition. Magnetic resonance spectrum of the brain will be studied using the 3T MRIs of the brain to detect brain metabolites markers, including N-acetyl aspartate, glutamate (Glu), glutathione (GSH) and γ-aminobutyric acid (GABA). Blood brain-derived neurotrophic factor, Glu, GSH and GABA levels and gut microbiota will also be assessed over this period. This study will also evaluate long-term outcomes of brain trauma, brain tumours and cerebrovascular disease via exploratory analyses. The primary outcome will be the difference in scores of a battery of cognitive tests after 12 weeks of sulforaphane treatment. The secondary outcomes will be changes in the Functional Activities Questionnaire (FAQ), the Patient Health Questionnaire (PHQ-9), the Self-Rating Anxiety Scale, the changes in T1-weighted MRI and resting-state functional MRI findings, and changes in brain and blood metabolic markers and gut microbiota at weeks 0 and 12. We expect that sulforaphane will yield favourable results in treating memory and learning deficits for patients with frontal brain damage. Cognitive functional treatment may also improve brain trauma, brain tumours and cerebrovascular outcomes.Ethics and disseminationThe study protocol has been approved by the Medical Ethics committee of the Xiangya Hospital of Central South University (No. 2017121019). The results will be disseminated in peer-reviewed journals and at international conferences.Trial registration numberThis trial was registered on Clinicaltrials.gov on 31 January 2020 (NCT04252261). The protocol version is V.1.0 (20 December 2019).

Olfactory Function in Head Trauma Patients a Link to Frontal Brain Damage?

2015 ◽  
Vol 46 (S 01) ◽  
Author(s):  
V. Schriever ◽  
T. Hummel ◽  
K. Grosser ◽  
M. Smitka
Keyword(s):  
Brain Damage ◽  
Head Trauma ◽  
Olfactory Function ◽  
Trauma Patients ◽  
Frontal Brain

scholarly journals Zingiber officinaleMitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Jinatta Jittiwat ◽  
Terdthai Tongun ◽  
Supaporn Muchimapura ◽  
Kornkanok Ingkaninan
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Neuroprotective Effect ◽  
Morris Water Maze Test ◽  
Brain Infarct ◽  
Ginger Rhizome ◽  
The Brain

Cerebral ischemia is known to produce brain damage and related behavioral deficits including memory. Recently, accumulating lines of evidence showed that dietary enrichment with nutritional antioxidants could reduce brain damage and improve cognitive function. In this study, possible protective effect ofZingiber officinale, a medicinal plant reputed for neuroprotective effect against oxidative stress-related brain damage, on brain damage and memory deficit induced by focal cerebral ischemia was elucidated. Male adult Wistar rats were administrated an alcoholic extract of ginger rhizome orally 14 days before and 21 days after the permanent occlusion of right middle cerebral artery (MCAO). Cognitive function assessment was performed at 7, 14, and 21 days after MCAO using the Morris water maze test. The brain infarct volume and density of neurons in hippocampus were also determined. Furthermore, the level of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in cerebral cortex, striatum, and hippocampus was also quantified at the end of experiment. The results showed that cognitive function and neurons density in hippocampus of rats receiving ginger rhizome extract were improved while the brain infarct volume was decreased. The cognitive enhancing effect and neuroprotective effect occurred partly via the antioxidant activity of the extract. In conclusion, our study demonstrated the beneficial effect of ginger rhizome to protect against focal cerebral ischemia.

A novel cognitive function test for detection of alcoholic brain damage

1983 ◽  
Vol 22 (4) ◽  
pp. 567-569 ◽  
Author(s):  
R. Draper ◽  
A. Manning ◽  
M. Daly ◽  
J. Larraghy
Keyword(s):  
Cognitive Function ◽  
Brain Damage ◽  
Function Test ◽  
Alcoholic Brain Damage ◽  
Cognitive Function Test

Paroxysmal speech disorder following left frontal brain damage

1991 ◽  
Vol 40 (2) ◽  
pp. 266-273
Author(s):  
M NAGAFUCHI
Keyword(s):  
Brain Damage ◽  
Speech Disorder ◽  
Frontal Brain

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

2020 ◽  
Vol 24 (6) ◽  
pp. 865-873
Author(s):  
Dilek ÖZBEYLİ ◽  
Gizem YARIMBAŞ ◽  
Büşra ERTAŞ ◽  
Ali ŞEN ◽  
Selin ŞAKARCAN
Keyword(s):  
Cognitive Function ◽  
Brain Damage ◽  
High Fat Diet ◽  
Myrtus Communis ◽  
High Fat

Smartphone Application Program Development for Cognitive Function Improvement after Brain Damage

2016 ◽  
Vol 10 (4) ◽  
pp. 321
Author(s):  
Myoung Heo ◽  
Yun-Woong Paek ◽  
Won-Seuk Choi ◽  
Min-Ji Kwon ◽  
Mun-Ju Kim ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Brain Damage ◽  
Program Development ◽  
Smartphone Application ◽  
Application Program

scholarly journals Conditionally Immortalized, Multipotential and Multifunctional Neural Stem Cell Lines as an Approach to Clinical Transplantation

2000 ◽  
Vol 9 (2) ◽  
pp. 153-168 ◽  
Author(s):  
J. A. Gray ◽  
G. Grigoryan ◽  
D. Virley ◽  
S. Patel ◽  
J. D. Sinden ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cell Suspension ◽  
Brain Damage ◽  
Basal Forebrain ◽  
Cholinergic System ◽  
Recovery Of Function ◽  
Fetal Brain ◽  
Nucleus Basalis ◽  
Ethanol Administration ◽  
Projection System

Experiments are described using rats with two kinds of brain damage and consequent cognitive deficit (in the Morris water maze, three-door runway, and radial maze): 1) ischemic damage to the CA1 hippocampal cell field after four-vessel occlusion (4VO), and 2) damage to the forebrain cholinergic projection system by local injection of excitotoxins to the nuclei of origin or prolonged ethanol administration. Cell suspension grafts derived from primary fetal brain tissue display a stringent requirement for homotypical cell replacement in the 4VO model: cells from the embryonic day (E)18–19 CA1 hippocampal subfield, but not from CA3 or dentate gyrus or from E16 basal forebrain (cholinergic rich) led to recovery of cognitive function. After damage to the cholinergic system, conversely, recovery of function was seen with cell suspension grafts from E16 basal forebrain or cholinergic-rich E14 ventral mesencephalon, but not with implants of hippocampal tissue. These two models therefore provided a test of multifunctionality for a clonal line of conditionally immortalized neural stem cells, MHP36, derived from the E14 “immortomouse” hippocampal anlage. Implanted above the damaged CA1 cell field in 4VO-treated adult rats, these cells (multipotential in vitro) migrated to the damaged area, reconstituted the gross morphology of the CA1 pyramidal layer, took up both neuronal and glial phenotypes, and gave rise to cognitive recovery. Similar recovery of function and restoration of species-typical morphology was observed when MHP36 cells were implanted into marmosets with excitotoxic CA1 damage. MHP36 implants led to recovery of cognitive function also in two experiments with rats with excitotoxic damage to the cholinergic system damage, either unilaterally in the nucleus basalis or bilaterally in both the nucleus basalis and the medial septal area. Thus, MHP36 cells are both multipotent (able to take up multiple cellular phenotypes) and multifunctional (able to repair diverse types of brain damage).

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