Inhibition of Retinal Pigment Epithelial Cell Senescence by Metformin: Implications for the Treatment of Macular Degeneration

Japanese Journal of Ophthalmology and Research ◽

10.31546/2732-4516.1005 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Michael R. Kozlowski ◽

Bryan Grossman ◽

Alex Kneeland ◽

Shelby Zemski ◽

Abretia Crandell ◽

...

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Senescence ◽

Pigment Epithelial

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BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

Journal of Biological Chemistry ◽

10.1074/jbc.m809393200 ◽

2009 ◽

Vol 284 (14) ◽

pp. 9529-9539 ◽

Author(s):

DanHong Zhu ◽

Jian Wu ◽

Christine Spee ◽

Stephen J. Ryan ◽

David R. Hinton

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Senescence ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Retinal Pigment Epithelial Cell Transplantation In Age- Related Macular Degeneration

Age-Related Macular Degeneration, Second Edition ◽

10.1201/9780203909157.ch25 ◽

2002 ◽

Author(s):

Tongalp Tezel ◽

Lucian Del Priore ◽

Henry Kaplan

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Cell Transplantation ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration

Matrix Biology ◽

10.1016/j.matbio.2018.03.013 ◽

2018 ◽

Vol 70 ◽

pp. 84-101 ◽

Author(s):

Chia-yi Chen ◽

Esther Melo ◽

Peter Jakob ◽

Arno Friedlein ◽

Brigitta Elsässer ◽

...

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

Age Related ◽

Thrombospondin 1

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Interferon‐γ induces retinal pigment epithelial cell Ferroptosis by a JAK1‐2/STAT1/SLC7A11 signaling pathway in Age‐related Macular Degeneration

FEBS Journal ◽

10.1111/febs.16272 ◽

2021 ◽

Author(s):

Ting‐Ting Wei ◽

Meng‐Yuan Zhang ◽

Xin‐Hua Zheng ◽

Tian‐Hua Xie ◽

Wenjuan Wang ◽

...

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Signaling Pathway ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Interferon Γ ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

Progress in Retinal and Eye Research ◽

10.1016/j.preteyeres.2015.09.002 ◽

2016 ◽

Vol 51 ◽

pp. 69-89 ◽

Author(s):

Deborah A. Ferrington ◽

Debasish Sinha ◽

Kai Kaarniranta

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Retinal Pigment Epithelial Cell Apoptosis is Influenced by a Combination of Macrophages and Soluble Mediators Present in Age-Related Macular Degeneration

Current Eye Research ◽

10.3109/02713683.2015.1109129 ◽

2016 ◽

Vol 41 (9) ◽

pp. 1235-1244 ◽

Author(s):

Gayathri Devarajan ◽

Jennifer Niven ◽

John V. Forrester ◽

Isabel J. Crane

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Cell Apoptosis ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

Age Related ◽

Epithelial Cell Apoptosis

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Inhibition of Sumoylation Alleviates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Represses Proinflammatory Gene Expression

Current Molecular Medicine ◽

10.2174/1566524019666190107154250 ◽

2019 ◽

Vol 18 (9) ◽

pp. 575-583 ◽

Author(s):

Q. Sun ◽

W. Qing ◽

R. Qi ◽

M. Zou ◽

L. Gong ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Epithelial Cell ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Senescence ◽

Pigment Epithelial ◽

Proinflammatory Gene ◽

Proinflammatory Gene Expression

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Retinal Pigment Epithelial Cell Transplantation and Macular Reconstruction for Age-Related Macular Degeneration

Age-Related Macular Degeneration, Second Edition ◽

10.3109/9781420019865-24 ◽

2007 ◽

pp. 329-348

Author(s):

Lucian Del Priore ◽

Henry Kaplan ◽

Tongalp Tezel

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Cell Transplantation ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration

American Journal of Ophthalmology ◽

10.1016/s0002-9394(00)00850-3 ◽

2001 ◽

Vol 131 (4) ◽

pp. 472-480 ◽

Author(s):

Lucian V Del Priore ◽

Henry J Kaplan ◽

Tongalp H Tezel ◽

Nobutsugu Hayashi ◽

Adam S Berger ◽

...

Keyword(s):

Epithelial Cell ◽

Macular Degeneration ◽

Cell Transplantation ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Expanded polytetrafluoroethylene as a substrate for retinal pigment epithelial cell growth and transplantation in age-related macular degeneration

British Journal of Ophthalmology ◽

10.1136/bjo.2009.169953 ◽

2011 ◽

Vol 95 (4) ◽

pp. 569-573 ◽

Author(s):

Y. Krishna ◽

C. Sheridan ◽

D. Kent ◽

V. Kearns ◽

I. Grierson ◽

...

Keyword(s):

Cell Growth ◽

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Age Related Macular Degeneration ◽

Expanded Polytetrafluoroethylene ◽

Pigment Epithelial ◽

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