scholarly journals Comparative study of the action of fluoroquinolones and vancomycin on biofilms of Staphylococcus strains isolated from infections of peritoneal dialysis catheters

2021 ◽  
Vol 2 (1) ◽  
pp. 1-4
Author(s):  
A. Rabhi ◽  
S. Mahrane ◽  
S.L. Nouar ◽  
R. Boushaki ◽  
A.N. Benkherif ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Comparative Study ◽  
Biofilm Formation ◽  
Microtiter Plate ◽  
Vitro Activity ◽  
In Vitro Activity

Background: catheter mediated infections are mainly caused by Staphylococci, the treatment of these infections is challenging because of biofilm formation. Methods: A microtiter plate biofilm assay was used to study the in vitro activity of Vancomycin, Ofloxacin and Levofloxacin on preformed biofilms of 30 stains of Staphylococcus isolated from peritoneal dialysis catheters and fluids at concentrations like those used intraperitoneally. Results: The in vitro action of the three antibiotics on preformed biofilms was statistically significant. it was significantly higher for Ofloxacin and Levofloxacin rather than that of Vancomycin. Discussion: the results demonstrate the effectiveness of the three antibiotics at concentrations like those used intraperitoneally and the superiority of Fluoroquinolones activity on Staphylococcal biofilms, these results correlate with the conclusions of other authors.

Comparison of the in Vitro Activity of Daptomycin and four other Antimicrobial Agents against Staphylococci Associated with CAPD Peritonitis

1988 ◽  
Vol 8 (4) ◽  
pp. 277-279
Author(s):  
Wendy L. Vaudry ◽  
Claudia Gratton ◽  
Kinga Kowalewska ◽  
Wanda M. Wenman
Keyword(s):  
Peritoneal Dialysis ◽  
Minimum Inhibitory Concentration ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Coagulase Negative Staphylococci ◽  
Vancomycin Resistant

The minimum inhibitory concentration (MIC) of daptomycin was compared with that of four other antimicrobial agents against clinically relevant staphylococci. Sixtyfive isolates were obtained from patients on continuous ambulatory peritoneal dialysis (CAPD) who contracted peritonitis. These isolates comprised 29 S. Sureus strains (all sensitive to oxacillin); 25 S. epidermidis strains (14 sensitive and 9 resistant to oxacillin); and 11 unspeciated coagulase-negative staphylococci (2 sensitive and 11 resistant to oxacillin). All of the oxacillin susceptible strains were inhibited by ≤2 mg/L of the five antibiotics tested. The oxacillin resistant staphylococci were also resistant to cefuroxime and variably resistant to cefamandole, but were uniformly susceptible to both vancomycin and daptomycin. Daptomycin possesses equivalent in vitro activity to vancomycin against strains of S. Sureus and coagulase negative staphylococci associated with CAPD peritonitis. If vancomycin resistance becomes a significant problem in these patients, and daptomycin is shown to be active against vancomycin resistant organisms, then it would have potential usefulness as an alternative to vancomycin in the treatment of peritonitis caused by multiply -resistant staphylococci.

In-vitro activity of temafloxacin against anaerobic bacteria: a comparative study

1991 ◽  
Vol 28 (suppl C) ◽  
pp. 25-30 ◽  
Author(s):  
S. M. Finegold ◽  
E. Molitoris ◽  
D. Reeves ◽  
H. M. Wexler
Keyword(s):  
Comparative Study ◽  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity
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