scholarly journals Radiation Induced Hemorrhagic Cystitis: Current Treatments

2017 ◽  
Vol 35 (4) ◽  
pp. 391
Author(s):  
Chaiyut Kongseang ◽  
Worapat Attawettayanon ◽  
Watid Kanchanawanichkul
Keyword(s):  
Mortality Rate ◽  
Hemorrhagic Cystitis ◽  
Moderate Degree ◽  
Gross Hematuria ◽  
Current Management ◽  
Correct Treatment ◽  
Radiation Cystitis ◽  
Common Presentation ◽  
Genitourinary Cancer ◽  
Radiation Induced

Gross hematuria is the most common presentation in genitourinary cancer patients. Patient with radiation cystitis also have similar presentation. Radiation cystitis can cause hematuria in various degrees, most of patients usually had mild to moderate degree which can be successfully treated with conservative treatment. In some patients, degree of hematuria may be severe that leads to mortality, correct treatment may decrease mortality rate. We review the current literature regarding the current management of radiation cystitis.

scholarly journals Treatment of Severe Refractory Hematuria due to Radiation-Induced Hemorrhagic Cystitis with Dexamethasone

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
José Carlos Rodrigues Nascimento ◽  
Márcio Wilker Soares Campelo ◽  
Iuri Arruda Aragão ◽  
José Fernando Bastos de Moura ◽  
Lúcio Flávio Gonzaga Silva ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Hemorrhagic Cystitis ◽  
Hospital Emergency ◽  
Gross Hematuria ◽  
Saline Irrigation ◽  
Pelvic Neoplasms ◽  
Epoetin Alpha ◽  
Dexamethasone Therapy ◽  
Radiation Induced ◽  
Aggressive Interventions

Treatment of pelvic neoplasms with radiotherapy may develop sequelae, especially RHC. An 85-year-old male patient was admitted to a hospital emergency with gross hematuria leading to urinary retention and was diagnosed with RHC. The urinary bladder was probed, unobstructed, and maintained in continuous three-way saline irrigation. During 45 days of hospitalization, the patient underwent two cystoscopic procedures for urinary bladder flocculation, whole blood transfusions, and one platelet apheresis. None of these interventions led to clinical resolution. As the patient hematological condition was deteriorating, dexamethasone (4 mg i.v., bolus of 6/6, 12/12, and 24 h during five days) and epoetin alpha (1000 IU, 1 ml, s.c., for four weeks) were administered which led to the remission of the urinary bleeding. Dexamethasone therapy may be considered for RHC, when conventional treatments are not effective or are not possible, avoiding more aggressive interventions such as cystectomy.

64: Intravesical Instillation of Epinephrine in Patients with Intractable Hemorrhagic Cystitis Due to Radiation Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 22-22
Author(s):  
Yung C. Chow ◽  
Jong M. Hsu ◽  
Wen C. Lin ◽  
Huang K. Chang ◽  
Yuh C. Yang ◽  
...  
Keyword(s):  
Hemorrhagic Cystitis ◽  
Intravesical Instillation ◽  
Radiation Cystitis

scholarly journals Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 21
Author(s):  
Carole Helissey ◽  
Sophie Cavallero ◽  
Clément Brossard ◽  
Marie Dusaud ◽  
Cyrus Chargari ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Therapeutic Strategy ◽  
Randomized Trials ◽  
Clinical Presentation ◽  
Therapeutic Approaches ◽  
Radiation Cystitis ◽  
Fibrotic Process ◽  
Radiation Induced ◽  
Therapeutic Irradiation ◽  
Underlying Pathophysiology

Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers. Its clinical management remains unclear, and few preclinical data are available on its underlying pathophysiology. The therapeutic strategy is difficult to establish because few prospective and randomized trials are available. In this review, we report on the clinical presentation and pathophysiology of radiation cystitis. Then we discuss potential therapeutic approaches, with a focus on the immunopathological processes underlying the onset of radiation cystitis, including the fibrotic process. Potential therapeutic avenues for therapeutic modulation will be highlighted, with a focus on the interaction between mesenchymal stromal cells and macrophages for the prevention and treatment of radiation cystitis.

Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis

2015 ◽  
Vol 22 (10) ◽  
pp. 962-966 ◽  
Author(s):  
Tiago M Ribeiro de Oliveira ◽  
António J Carmelo Romão ◽  
Francisco M Gamito Guerreiro ◽  
Tomé M Matos Lopes
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Hemorrhagic Cystitis ◽  
Radiation Induced

Laparoscopic Cystoprostatectomy for Radiation-Induced Hemorrhagic Cystitis

2009 ◽  
Vol 23 (2) ◽  
pp. 275-278 ◽  
Author(s):  
Amr F. Fergany ◽  
Ayman S. Moussa ◽  
Inderbir S. Gill
Keyword(s):  
Hemorrhagic Cystitis ◽  
Radiation Induced

scholarly journals Current management of radiation cystitis: a review and practical guide to clinical management

2018 ◽  
Vol 123 (4) ◽  
pp. 585-594 ◽  
Author(s):  
Claire Pascoe ◽  
Catriona Duncan ◽  
Benjamin W. Lamb ◽  
Niall F. Davis ◽  
Thomas H. Lynch ◽  
...  
Keyword(s):  
Clinical Management ◽  
Current Management ◽  
Radiation Cystitis ◽  
Practical Guide

scholarly journals A CASE OF PREDNISOLONE THERAPY FOR RADIATION-INDUCED HEMORRHAGIC CYSTITIS

2011 ◽  
Vol 102 (3) ◽  
pp. 600-602 ◽  
Author(s):  
Masato Yanagi ◽  
Taiji Nishimura ◽  
Susumu Kurita ◽  
Chorsu Lee ◽  
Yukihiro Kondo ◽  
...  
Keyword(s):  
Hemorrhagic Cystitis ◽  
Prednisolone Therapy ◽  
Radiation Induced

Early hyperbaric oxygen therapy improves radiation induced hemorrhagic cystitis and proctitis

2019 ◽  
Vol 18 (11) ◽  
pp. e3507
Author(s):  
H. Takeda ◽  
G. Kimura ◽  
J. Akatsuka ◽  
Y. Endo ◽  
T. Hayashi ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Hemorrhagic Cystitis ◽  
Radiation Induced

scholarly journals Severe Hemorrhagic Cystitis Caused by Cyclophosphamide and Capecitabine Therapy in Breast Cancer Patients: Two Case Reports and Literature Review

2019 ◽  
Vol 12 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Toshihiro Tanaka ◽  
Yuta Nakashima ◽  
Hidenori Sasaki ◽  
Michio Masaki ◽  
Ai Mogi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Total Dose ◽  
Case Reports ◽  
Blood Clot ◽  
Hemorrhagic Cystitis ◽  
Lower Abdominal Pain ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Gross Hematuria ◽  
Bladder Irrigation

Combined oral cyclophosphamide and capecitabine (XC) chemotherapy is used for metastatic breast cancer (MBC) patients. We report herein two MBC patients who developed severe hemorrhagic cystitis after XC therapy. Case 1: A 67-year-old woman with MBC had received XC therapy for 2.5 years. After a sudden onset of lower abdominal pain and gross hematuria, cystoscopy revealed a urinary bladder mucosa showing diffuse dilation of the capillaries and a large blood clot. A total dose of 60.8 g cyclophosphamide had been given and the XC regimen was discontinued immediately. The patient experienced frequent episodes of bladder tamponade over 18 months and underwent continuous bladder irrigation and cystoscopic fulguration. Hyperbaric oxygen therapy (HBOT) provided only temporary relief and the patient subsequently developed hemorrhagic shock. A bilateral ureterostomy was eventually performed. Case 2: A 65-year-old woman with MBC was given XC for 3 years, but this was discontinued after she developed new lung lesions. The patient was given a total dose of 78.4 g of cyclophosphamide. A month later, the patient complained of intermittent gross hematuria, which progressed to persistent macroscopic hematuria for 1 week. She underwent continuous bladder irrigation with saline, without an improvement in her bladder tamponade. Subsequently, the bleeding ceased completely after HBOT. Some MBC cases can be controlled for a long time with XC therapy. For those cases, we need to realize that severe hemorrhagic cystitis may occur. Even at a low dose, requires testing periodically for occult blood in the urine to detect the early stages of cystitis.

Sign in / Sign up

Export Citation Format

Share Document