METHOD OF DETERMINING THE IMMUNOGENIC ACTIVITY OF LIVE VACCINE AGAINST RABIES IN WILD ANIMALS IN MICE

2020 ◽  
pp. 53-57
Author(s):  
V. A. Babak ◽  
A. A. Gusev ◽  
I. A. Puntus ◽  
A. S. Smailova
Keyword(s):  
Infection Control ◽  
Rabies Virus ◽  
Experimental Infection ◽  
Oral Immunization ◽  
Live Vaccine ◽  
Wild Animals ◽  
Method Of Evaluation

The results of alternative studies on the immunogenic activity of live rabies vaccines for oral immunization of wild carnivorous animals are presented. The method of evaluation of immunogenicity using a model of oral immunization in mice with experimental infection control rabies virus CVS in the dose of 10–100 MLD50/0,03 ml. Once entered immunizing dose for white mice, weighing 12–14 g were 56.200 MLD50, the titers of VNA ranged from 1:6 to 1:16 (3,0–4,0 log2) and above.

Oral immunization of foxes with avirulent rabies virus mutants

1988 ◽  
Vol 11 ◽  
pp. 75
Author(s):  
H Leblois ◽  
C Tuffereau ◽  
J Blancou ◽  
A Aubert ◽  
Flamand A
Keyword(s):  
Rabies Virus ◽  
Oral Immunization

scholarly journals Pathways for transfer and spreading of Aujeszky’s disease to carnivora

2006 ◽  
Vol 60 (5-6) ◽  
pp. 369-375
Author(s):  
Ivan Pusic ◽  
Bosiljka Djuricic ◽  
Sava Lazic ◽  
Radosla Dosen ◽  
Jasna Prodanov
Keyword(s):  
Viral Infection ◽  
Live Vaccine ◽  
Wild Animals ◽  
Contagious Disease ◽  
Aujeszky's Disease ◽  
Aujeszky’S Disease ◽  
Butcher Shops ◽  
Vojvodina Province

Aujeszky?s disease (Morbus Aujeszky) is an acute viral contagious disease occurring in a large number of domestic and wild animals. This epizootiological disease has been present in our country for quite some time now, and it has been increasingly frequently diagnosed in carnivora in the recent years. The objective of the investigations was to determine and establish the pathways for the transfer and the manner of spreading of the MA virus to carnivora. Epizootiological data on the appearance of MA, collected in the field, as well as an epizootiological report by the Serbian Ministry of Agriculture and of the Federal Ministry for Agriculture were used as material. Detailed epizootiological, clinical, pathomorphological, and laboratory analyses were performed in five critical spots for MA registered in the territory of Vojvodina province. We established the following pathways for the spread of the MA viral infection to carnivora: the consumption of thermally unprocessed swine carcasses, the consumption of thermally unprocessed pork originating from butcher shops or from regular slaughter on private farms, the consumption of viscera from emergency slaughtered sheep, cohabitation and contact with infected swine, and vaccination using a live vaccine contaminated with the MA virus.

scholarly journals Testing of Ferarabivac anti-rabies live vaccine for wild carnivores for its immunogenicity and protectivity

2020 ◽  
pp. 31-37
Author(s):  
A. V. Shishkov ◽  
D. A. Lozovoy ◽  
A. V. Borisov ◽  
D. V. Mikhalishin
Keyword(s):  
Rabies Virus ◽  
Neutralizing Antibodies ◽  
Oral Vaccine ◽  
Fatal Outcome ◽  
Maximum Level ◽  
Live Vaccine ◽  
Post Vaccination ◽  
Wild Carnivores ◽  
Antibody Titres ◽  
Raccoon Dogs

Rabies is one of the most important human and animal viral diseases, being one of the most dangerous zoonoses, causing damage to the central nervous system with an inevitable fatal outcome. This disease is of global concern, and it attracts special attention of international organizations (WHO, OIE, FAO, GARC) and of veterinary services in many countries around the world. A variety of anti-rabies vaccines have been used for specific rabies prevention in wild carnivores, however, the safety and effectiveness of some of them is doubtful. New, more advanced products are being developed, one of which is Ferarabivac, a live oral vaccine. The vaccine was tested for its immunogenicity and protectivity in wild carnivores. The optimal immunizing dose was 2.0 cm3, with the infectivity titre of RV-97 strain of at least 6.00 lg KKID50/cm3. Anti-rabies antibody titres detected in the blood sera of foxes and raccoon dogs 14 days post vaccination, were 0.70 ± 0.18 and 0.73 ± 0.19 IU/cm3, respectively, which provided protection against rabies virus infection (≥ 0.50 IU/cm3). Rabies virus neutralizing antibodies in foxes reached their maximum level of 4.30 ± 0.32 IU/cm3 50 days post vaccination. Antibody titres in vaccinated raccoon dogs also reached their maximum level of 4.53 ± 0.27 IU/cm3 50 days post vaccination. The minimum protective threshold levels of serum neutralizing antibodies was determined 12 months after the vaccination, and it was 0.62 ± 0.28 and 0.71 ± 0.17 IU/cm3 in foxes and raccoon dogs, respectively, which proves the necessity to perform booster vaccination one year later. No animals vaccinated against rabies with Ferarabivac live vaccine showed any clinical signs of the disease during the entire observation period following the challenge test carried out 30 days post vaccination.

scholarly journals Human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, between 2002 and 2006

2007 ◽  
Vol 40 (6) ◽  
pp. 617-621 ◽  
Author(s):  
Filipe Dantas-Torres ◽  
Edmilson Ferreira de Oliveira-Filho
Keyword(s):  
Rabies Virus ◽  
Human Exposure ◽  
Nonhuman Primates ◽  
Prophylactic Treatment ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Wild Animals ◽  
Health Unit ◽  
Multifaceted Approach ◽  
Exposure Prophylaxis

The aim of the present study was to evaluate the data on human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, Brazil. Data from 7,062 patients who underwent antirabies prophylactic treatment in Olinda between 2002 and 2006 were analyzed. As expected, dogs and cats were involved in most of the cases; i.e. 82.3 and 16.3%, respectively. Attacks by nonhuman primates, bats and other species (unspecified) were also reported. Among the 7,062 patients who underwent antirabies treatment, 582 patients abandoned the treatment, either by indication from the health unit (195) or by their own decision (387). In conclusion, this study has indicated that prophylaxis for human rabies in this urban area will require a multifaceted approach, including health education, post-exposure prophylaxis, systematic vaccination for dogs and cats, and possibly selective control over wild animals such as hematophagous bats.

Oral immunization of wild boar and domestic pigs with attenuated live vaccine protects against Pseudorabies virus infection

2012 ◽  
Vol 161 (1-2) ◽  
pp. 20-25 ◽  
Author(s):  
Christina Maresch ◽  
Elke Lange ◽  
Jens P. Teifke ◽  
Walter Fuchs ◽  
Barbara Klupp ◽  
...  
Keyword(s):  
Virus Infection ◽  
Wild Boar ◽  
Pseudorabies Virus ◽  
Oral Immunization ◽  
Live Vaccine ◽  
Domestic Pigs
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