Primary intracranial endodermal sinus tumor

1979 ◽  
Vol 50 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Thomas J. Eberts ◽  
Robert C. Ransburg
Keyword(s):  
Pineal Region ◽  
Yolk Sac ◽  
Endodermal Sinus Tumor ◽  
Cranial Cavity ◽  
Content Type ◽  
Suprasellar Region ◽  
Sinus Tumor ◽  
Fine Print

✓ Endodermal sinus tumor (yolk sac carcinoma), a germinal neoplasm, is rarely primary in the cranial cavity. The authors add a third case with the tumor located in the anterior third ventricular (suprasellar) region to the literature. Seventeen previously reported intracranial cases, mostly in the pineal region, are briefly reviewed.

Pathogenesis of intracranial germ cell tumors reconsidered

1999 ◽  
Vol 90 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Keiji Sano
Keyword(s):  
Survival Rate ◽  
Germ Cell ◽  
Survival Rates ◽  
Germ Cell Tumors ◽  
Yolk Sac ◽  
Endodermal Sinus Tumor ◽  
Content Type ◽  
Intracranial Germ Cell Tumors ◽  
Sinus Tumor ◽  
Fine Print

Object. To determine the pathogenesis of intracranial germ cell tumors (GCTs), the author studied 153 cases of these tumors encountered through 1994, 62.7% of which showed monotypic histological patterns and 37.3% of which were shown to be mixed tumors.Methods. Six patients died soon after admission and underwent autopsy; the other patients underwent surgery followed by radio- and/or chemotherapy. One hundred thirty-four cases were followed through the end of 1997. All patients with a choriocarcinoma died within 1 year. Patients with a yolk sac tumor (endodermal sinus tumor) or an embryonal carcinoma also had poor outcomes. Patients with a mature teratoma had 5- and 10-year survival rates of 93% each. Patients with an immature teratoma had 5- and 10-year survival rates of 86% each, whereas patients who had a teratoma with malignant transformation had a 3-year survival rate of 50%. Patients with a germinoma had a 5-year survival rate of 96% and a 10-year survival rate of 93%. These results may bring into question the validity of the germ cell theory because germinoma, which should be the most undifferentiated tumor according to the theory, was the most benign and choriocarcinoma and yolk sac tumor (endodermal sinus tumor), which should be the most differentiated tumors, were the most malignant according to results obtained during the follow-up study.Conclusions. Germ cell tumors other than germinomas may not originate from one single type of cell (primordial germ cells). The embryonic cells of various stages of embryogenesis may perhaps be misplaced in the bilaminar embryonic disc at the time of the primitive streak formation, becoming involved in the stream of lateral mesoderm and carried to the neural plate area to become incorrectly enfolded into the brain at the time of neural tube formation. The author propounds the following hypothesis: tumors composed of cells resembling the cells that appear in the earlier stages of embryogenesis (ontogenesis) are more malignant than those composed of cells resembling the cells that appear in the later stages of embryogenesis.

Primary pineal endodermal sinus tumor with elevated serum and CSF alphafetoprotein levels

1980 ◽  
Vol 53 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Norio Arita ◽  
Shoji Bitoh ◽  
Yukitaka Ushio ◽  
Toru Hayakawa ◽  
Hiroshi Hasegawa ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Elevated Serum ◽  
Germ Cell Tumors ◽  
Pineal Region ◽  
Endodermal Sinus Tumor ◽  
Immunofluorescence Method ◽  
Content Type ◽  
Intracranial Germ Cell Tumors ◽  
Sinus Tumor ◽  
Sensitive Marker

✓ A 12-year-old girl with an alphafetoprotein-producing brain tumor in the pineal region is presented. The marker was detected in both serum and cerebrospinal fluid. The amount of the marker decreased after irradiation of the tumor and systemic chemotherapy and increased prior to tumor recurrence. At autopsy, the tumor was histopathologically diagnosed as an endodermal sinus tumor, and alphafetoprotein was demonstrated in the tumor cells by the immunofluorescence method. Alphafetoprotein may represent a specific and sensitive marker for predicting tumor histopathology and for monitoring the therapeutic response in patients with primary intracranial germ-cell tumors.

Successful treatment of a pineal endodermal sinus tumor

1991 ◽  
Vol 74 (5) ◽  
pp. 832-836 ◽  
Author(s):  
Carine S. Kirkove ◽  
Andrew P. Brown ◽  
Lindsay Symon
Keyword(s):  
Adjuvant Chemotherapy ◽  
Successful Treatment ◽  
Adjuvant Treatment ◽  
Multidisciplinary Treatment ◽  
Rare Tumor ◽  
Endodermal Sinus Tumor ◽  
Review Of The Literature ◽  
Content Type ◽  
Sinus Tumor ◽  
Fine Print

✓ A patient with a pineal endodermal sinus tumor is presented who was successfully treated by a combination of surgery, adjuvant chemotherapy, and craniospinal irradiation. Two years after diagnosis, he is free of any disease. A review of the literature shows that such an outcome is very unusual. A multidisciplinary treatment is recommended for this rare tumor, using chemotherapy as adjuvant treatment.

Malignant astrocytoma following radiotherapy of a craniopharyngioma

1978 ◽  
Vol 48 (4) ◽  
pp. 622-627 ◽  
Author(s):  
Richard L. Sogg ◽  
Sarah S. Donaldson ◽  
Craig H. Yorke
Keyword(s):  
Experimental Evidence ◽  
Temporal Lobe ◽  
Malignant Astrocytoma ◽  
Content Type ◽  
Suprasellar Region ◽  
The Right ◽  
Fine Print

✓ A 9-year-old schoolgirl received 6007 rads to the suprasellar region for craniopharyngioma. Five years later, a malignant astrocytoma developed in the right temporal lobe. We cite clinical and experimental evidence to support our suspicion that the glioma may have been induced by radiation.

Endodermal Sinus Tumor (Yolk Sac Tumor) of the Ear

1987 ◽  
Vol 113 (2) ◽  
pp. 200-203 ◽  
Author(s):  
R. J. Stanley ◽  
B. W. Scheithauer ◽  
E. I. Thompson ◽  
D. B. Kispert ◽  
L. H. Weiland ◽  
...  
Keyword(s):  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Endodermal Sinus Tumor ◽  
Sinus Tumor

Neuroepithelial cyst in the optic nerve

1987 ◽  
Vol 67 (1) ◽  
pp. 137-139 ◽  
Author(s):  
Alberto Isla ◽  
José Palacios ◽  
José M. Roda ◽  
Manuel Gutierrez ◽  
Cesáreo González ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Computerized Tomography ◽  
Cystic Lesion ◽  
Histological Study ◽  
Content Type ◽  
Neuroepithelial Cyst ◽  
Loss Of Vision ◽  
Progressive Loss ◽  
Suprasellar Region ◽  
Fine Print

✓ A 34-year-old woman presented with progressive loss of vision in her left eye of 2 months' evolution. Computerized tomography showed a hypodense lesion in the suprasellar region. At surgery a cystic lesion was found inside the optic nerve. Histological study proved it to be a neuroepithelial cyst. The pathogenesis of a neuroepithelial cyst in such an exceptional site is discussed.

Yolk sac carcinoma (endodermal sinus tumor).Ultrastructure and histogenesis of gonadal and extragonadal tumors in comparison with normal human yolk sac

Cancer ◽  
1977 ◽  
Vol 39 (4) ◽  
pp. 1462-1474 ◽  
Author(s):  
Francisco Nogales-Fernandez ◽  
Steven G. Silverberg ◽  
Paul A. Bloustein ◽  
Antonio Martinez-Hernandez ◽  
G. Barry Pierce
Keyword(s):  
Yolk Sac ◽  
Endodermal Sinus Tumor ◽  
Normal Human ◽  
Sinus Tumor

Clinicopathological study of 53 tumors of the pineal region

1973 ◽  
Vol 39 (4) ◽  
pp. 455-462 ◽  
Author(s):  
Umberto DeGirolami ◽  
Henry Schmidek
Keyword(s):  
General Hospital ◽  
Massachusetts General Hospital ◽  
Pineal Region ◽  
Pathological Features ◽  
Content Type ◽  
Clinicopathological Study ◽  
Ventricular Tumors ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ Fifty-three cases of pineal and posterior-third ventricular tumors seen at the Massachusetts General Hospital from 1920 to 1972 are reviewed. This series includes 35 pathologically verified tumors and 18 cases accepted as pineal neoplasms on clinical and radiographic grounds. A plan of management is proposed based on a correlation between the clinical and pathological features and the response of each type of tumor to the currently available modes of therapy.

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