Impact of adverse drug reactions on quality of life in patients with schizophrenia

Abstract Purpose This study was to assess the status of quality of life and explore the possible factors correlated with quality of life among non-small cell lung cancer (NSCLC) patients with skin adverse drug reactions under targeted therapy. Methods We performed a cross-sectional study including 536 NSCLC patients with skin adverse drug reactions by targeted therapy in cancer outpatient clinics of three hospitals in China between May 2020 and May 2021. And we collected data with structured questionnaires and identified the relationships among coping style, self-management and quality of life by Pearson correlation analysis and multiple linear regression algorithm. Results The total score of quality of life was 46±12.84 in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy. In multiple linear regression analysis, we identified the significant factors associated with quality of life including age, education level, combination of medicine, Charlson Comorbidity Index (CCI), stages of disease, facing, yield, symptom management, daily activity management, psychological and emotional management, self-efficacy and self-management (P < 0.05). Conclusions NSCLC patients with skin adverse drug reactions undergoing targeted therapy generally had a compromised quality of life. And the critical factors that affected the status of quality of life were age, education level, co-morbidity, the combinatorial application of drugs and stage of disease, self-management and coping styles.

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Adverse drug reactions and drug interactions

10.1093/med/9780199603640.003.0002 ◽

2012 ◽

Cited By ~ 3

Author(s):

Philip Wiffen ◽

Marc Mitchell ◽

Melanie Snelling ◽

Nicola Stoner

Keyword(s):

Quality Of Life ◽

Drug Interactions ◽

Adverse Drug Reactions ◽

Adverse Reactions ◽

Adverse Drug Events ◽

Hospital Environment ◽

Drug Reactions ◽

Significant Cost

Introduction to ADRs 14Classification of ADRs 15Adverse reactions: drug or disease? 16Helping patients understand the risk of ADRs 17Reporting ADRs 18Drug interactions 20Managing drug interactions 23Adverse drug reactions (ADRs), also known as ‘side effects’, ‘adverse drug events’, or ‘drug misadventures’, are a frequent cause of morbidity in hospital and the community. They have a significant cost both financially and in terms of quality of life. Few studies of ADRs have been carried out in the community so the effect on primary care is harder to assess, but studies in the hospital environment have shown the following. ...

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Neuropsychiatric adverse drug reactions induced by montelukast impair the quality of life in children with asthma

Journal of Asthma ◽

10.1080/02770903.2020.1861626 ◽

2020 ◽

pp. 1-14

Author(s):

Oznur Yilmaz Bayer ◽

Ipek Turktas ◽

Hacer Ilbilge Ertoy Karagol ◽

Sebnem Soysal ◽

Dilek Yapar

Keyword(s):

Quality Of Life ◽

Adverse Drug Reactions ◽

Drug Reactions ◽

Children With Asthma

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Adverse drug reactions and quality of life in HIV/AIDS patients: Advocacy on valuation and role of pharmacovigilance in developing countries

HIV & AIDS Review ◽

10.1016/j.hivar.2014.07.004 ◽

2015 ◽

Vol 14 (1) ◽

pp. 28-30 ◽

Cited By ~ 2

Author(s):

Imran Ahmed Syed ◽

Syed Azhar Syed Sulaiman ◽

Mohammad Azmi Hassali ◽

Christopher K.C. Lee

Keyword(s):

Quality Of Life ◽

Developing Countries ◽

Adverse Drug Reactions ◽

Drug Reactions ◽

Aids Patients ◽

Hiv Aids

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IMPACT OF ADVERSE DRUG REACTIONS OF TOPICAL ANTI-GLAUCOMA MEDICATIONS ON THE VISION-RELATED QUALITY OF LIFE IN PRIMARY OPEN ANGLE GLAUCOMA

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/910 ◽

2017 ◽

Vol 6 (56) ◽

pp. 4201-4205

Author(s):

Neeta Sidhan ◽

Beena Thankappan ◽

Georgey Joshy C ◽

Safna Fazil N

Keyword(s):

Quality Of Life ◽

Adverse Drug Reactions ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Drug Reactions ◽

Related Quality

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A STUDY ON INFECTIOUS DISEASE BURDEN AND ASSESSMENT OF ADVERSE DRUG REACTIONS AMONG TYPE- II DIABETES MELLITUS SUBJECTS

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v8i3.596 ◽

2019 ◽

Vol 8 (3) ◽

Author(s):

Adarsh Mathew ◽

Bharathi DR ◽

Abubaker Siddiq ◽

Akza K Alex ◽

Tejaswini S M

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Infectious Disease ◽

Infectious Diseases ◽

Adverse Drug Reactions ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Drug Reactions

Introduction: People with diabetes are more prone to development of infections. Elevated blood sugar levels enervate the patient’s immune system and make the patient vulnerable to infections.Assessing the prescription patterns assure quality medical care by providing feedback to the prescribers. Objectives: To assess the prevalence and the prescription pattern of antibiotics in infections associated with type II diabetes mellitus along with their quality of life. To assess the Adverse Drug Reactions associated with treatment of type-II diabetes mellitus. Materials and Methods: This prospective observational study was conducted in the General Medicine Department of Basaveshwara Medical College Hospital and Research Centre, Chitradurga for a period of 10 months. Results: In this study, a total of 300 diabetic subjects were included, out of which, 192 subjects were having infectious diseases. This study reveals association between infection and diabetes with a prevalence rate of 64%. The most commonly prescribed antibiotic was found to be ceftriaxone. The quality of life of the diabetic subjects associated with infections was found to be displeasing when assessed with a validated questionnaire. Conclusion: The study shows a higher rate of prevalence of infectious disease among diabetic subjects. It is suggested to conduct more studies on this topic. Keywords: Diabetes mellitus; Infectious diseases; Adverse drug reactions; Burden of disease.

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