Hyperpotentiation by Synthetic Double-Stranded RNA of Antibody Responses to Influenza Virus Vaccine in Adjuvant 65

1969 ◽  
Vol 131 (3) ◽  
pp. 809-817 ◽  
Author(s):  
A. F. Woodhour ◽  
A. Friedman ◽  
A. A. Tytell ◽  
M. R. Hilleman
Keyword(s):  
Influenza Virus ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine ◽  
Antibody Responses ◽  
Double Stranded Rna

Swine influenza virus vaccine: potentiation of antibody responses in rhesus monkeys

Science ◽  
1977 ◽  
Vol 197 (4310) ◽  
pp. 1289-1290 ◽  
Author(s):  
E. Stephen ◽  
D. Hilmas ◽  
J. Mangiafico ◽  
H. Levy
Keyword(s):  
Influenza Virus ◽  
Virus Vaccine ◽  
Rhesus Monkeys ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Influenza Virus Vaccine ◽  
Antibody Responses

scholarly journals An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 117 ◽  
Author(s):  
Weina Sun ◽  
Allen Zheng ◽  
Robert Miller ◽  
Florian Krammer ◽  
Peter Palese
Keyword(s):  
Influenza Virus ◽  
Virus Vaccine ◽  
Matrix Protein ◽  
Antigenic Site ◽  
Influenza Virus Vaccine ◽  
Antibody Responses ◽  
The Matrix ◽  
Stalk Domain ◽  
Vaccine Approach ◽  
Multiple Strains

Universal influenza virus vaccine candidates that focus on the conserved hemagglutinin (HA) stalk domain and the extracellular domain of the matrix protein 2 (M2e) have been developed to increase the breadth of protection against multiple strains. In this study, we report a novel inactivated influenza virus vaccine approach that combines these two strategies. We inserted a human consensus M2e epitope into the immunodominant antigenic site (Ca2 site) of three different chimeric HAs (cHAs). Sequential immunization with inactivated viruses containing these modified cHAs substantially enhanced M2e antibody responses while simultaneously boosting stalk antibody responses. The combination of additional M2e antibodies with HA stalk antibodies resulted in superior antibody-mediated protection in mice against challenge viruses expressing homologous or heterosubtypic hemagglutinin and neuraminidase compared to vaccination strategies that targeted the HA stalk or M2e epitopes in isolation.

scholarly journals Homologous and heterologous antibody responses to subunit influenza virus vaccine

1978 ◽  
Vol 81 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Brian J. Feery ◽  
M. G. Evered ◽  
Kathleen Hayes
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Virus Vaccine ◽  
Geometric Mean ◽  
Influenza Virus Vaccine ◽  
Antibody Responses ◽  
Antibody Titres ◽  
Adult Volunteers ◽  
Representative Member ◽  
Heterologous Antibody

SummaryIn a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/ 840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (H0N1).There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Formulation with CpG ODN enhances antibody responses to an equine influenza virus vaccine

2006 ◽  
Vol 114 (1-2) ◽  
pp. 103-110 ◽  
Author(s):  
A.M. Lopez ◽  
R. Hecker ◽  
G. Mutwiri ◽  
S. van Drunen Littel-van den Hurk ◽  
L.A. Babiuk ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine ◽  
Antibody Responses ◽  
Cpg Odn ◽  
Equine Influenza Virus ◽  
Equine Influenza
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