Effects of Copper and Zinc Status of Rats on Erythrocyte Stability and Superoxide Dismutase Activity

1978 ◽  
Vol 158 (2) ◽  
pp. 279-282 ◽  
Author(s):  
W. J. Bettger ◽  
T. J. Fish ◽  
B. L. O'Dell
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Zinc Status ◽  
Copper And Zinc ◽  
Erythrocyte Stability

Superoxide Dismutase Activity and Zinc Status: a Study in Animals and Man

1992 ◽  
Vol 3 (1) ◽  
pp. 13-26 ◽  
Author(s):  
C. Coudray ◽  
M. J. Richard ◽  
F. Laporte ◽  
P. Faure ◽  
A. M. Roussel ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Zinc Status

scholarly journals The influence of high nervous activity type on superoxide dismutase activity and content of Copper and Zinc in the blood of cows

2018 ◽  
Vol 20 (4) ◽  
pp. 55-60
Author(s):  
Yu. O. Sisyuk ◽  
◽  
Yu. V. Kravchenko-Dovga ◽  
V. I. Karpovsky ◽  
O. V. Danchuk ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
High Nervous Activity ◽  
Nervous Activity ◽  
Superoxide Dismutase Activity ◽  
Activity Type ◽  
Copper And Zinc

scholarly journals Relationship between blood superoxide dismutase activity and zinc, copper, glutathione and metallothioneines concentrations in calves

BIOMATH ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 2111247
Author(s):  
Vladimir Safonov ◽  
Vadim Ermakov ◽  
Valentina Danilova ◽  
Vyacheslav Yakimenko
Keyword(s):  
Superoxide Dismutase ◽  
Enzyme Activity ◽  
Positive Relationship ◽  
Zinc Concentration ◽  
Venous Blood ◽  
The Other ◽  
Superoxide Dismutase Activity ◽  
Redox Processes ◽  
Significant Positive Relationship ◽  
Copper And Zinc

RedOx processes determine the resistance of the organism to pollutants. The aim of the study was to establish a possible relationship between copper and zinc concentration in the blood of calves and the enzyme activity of superoxide dismutase. The study was conducted in 2019 on 50 calves with a weight of 201-250 kg. The samples of venous blood were taken to estimate the level of hemoglobin, glutathione, metallothioneins, as well as zinc, copper, and superoxide dismutase activity. The obtained average values of these substances concentration were compared between each other. A positive correlation between the activity of superoxide dismutase and the concentration of zinc (r = 0.64) and copper (r = 0.87) in the blood of calves has been established. It may be because both metals are obligatory components of superoxide dismutase. There is also a positive relationship between the levels of copper and zinc (r = 0.68). For the other parameters, no reliable relationship was found. The data obtained indicate a positive relationship between the activity of superoxide dismutase and metal concentrations of copper and zinc in the blood of calves. At the same time, a more significant positive relationship is established for copper.

Serum extracellular superoxide dismutase activity as an indicator of zinc status in humans

1999 ◽  
Vol 69 (1) ◽  
pp. 45-57 ◽  
Author(s):  
Hee Y. Paik ◽  
Hyojee Joung ◽  
Joo Y. Lee ◽  
Hong K. Lee ◽  
Janet C. King ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Extracellular Superoxide Dismutase ◽  
Zinc Status

Cloning and Expression Analysis of Copper and Zinc Superoxide Dismutase (Cu/Zn-SOD) Gene fromBrassica campestrisL.

2014 ◽  
Vol 40 (4) ◽  
pp. 636 ◽  
Author(s):  
Xiu-Cun ZENG ◽  
Zi-Gang LIU ◽  
Peng-Hui SHI ◽  
Yao-Zhao XU ◽  
Jia SUN ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Expression Analysis ◽  
Cloning And Expression ◽  
Zinc Superoxide Dismutase ◽  
Copper And Zinc

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

2020 ◽  
Vol 13 (1) ◽  
pp. 76-83
Author(s):  
Aline Maria Brito Lucas ◽  
Joana Varlla de Lacerda Alexandre ◽  
Maria Thalyne Silva Araújo ◽  
Cicera Edna Barbosa David ◽  
Yuana Ivia Ponte Viana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Cardiac Hypertrophy ◽  
Superoxide Dismutase Activity ◽  
Heart Weight ◽  
Pharmacological Intervention ◽  
Wall Thickening ◽  
H2o2 Production ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

Background: Cardiac hypertrophy involves marked wall thickening or chamber enlargement. If sustained, this condition will lead to dysfunctional mitochondria and oxidative stress. Mitochondria have ATP-sensitive K+ channels (mitoKATP) in the inner membrane that modulate the redox status of the cell. Objective: We investigated the in vivo effects of mitoKATP opening on oxidative stress in isoproterenol- induced cardiac hypertrophy. Methods: Cardiac hypertrophy was induced in Swiss mice treated intraperitoneally with isoproterenol (ISO - 30 mg/kg/day) for 8 days. From day 4, diazoxide (DZX - 5 mg/kg/day) was used in order to open mitoKATP (a clinically relevant therapy scheme) and 5-hydroxydecanoate (5HD - 5 mg/kg/day) or glibenclamide (GLI - 3 mg/kg/day) were used as mitoKATP blockers. Results: Isoproterenol-treated mice had elevated heart weight/tibia length ratios (HW/TL). Additionally, hypertrophic hearts had elevated levels of carbonylated proteins and Thiobarbituric Acid Reactive Substances (TBARS), markers of protein and lipid oxidation. In contrast, mitoKATP opening with DZX avoided ISO effects on gross hypertrophic markers (HW/TL), carbonylated proteins and TBARS, in a manner reversed by 5HD and GLI. Moreover, DZX improved mitochondrial superoxide dismutase activity. This effect was also blocked by 5HD and GLI. Additionally, ex vivo treatment of isoproterenol- induced hypertrophic cardiac tissue with DZX decreased H2O2 production in a manner sensitive to 5HD, indicating that this drug also acutely avoids oxidative stress. Conclusion: Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy. This pharmacological intervention could be a potential therapeutic strategy to prevent oxidative stress associated with cardiac hypertrophy.

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