Abnormalities in Neuromuscular Transmission - A Review

The article covers the particular features of the neuro-muscular system in vibration disease of various types and severity by electroneuromyographical tests at the Department of Occupational Disorders, Regional Center for Occupational Disorders, Samara Medical and Sanitary Unit № 5 of the Kirov Region (State Budgetary Healthcare Institution of the Samara Region). Changes in excitability and functional mobility of the sensorimotor system, development of vegetative-sensory polyneuropathy depending on the vibration disease type, severity, and the length of exposure to vibration at work are found in vibration disease patients.

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Faculty Opinions recommendation of Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737867914.793574152 ◽

2020 ◽

Author(s):

Roger Bannister

Keyword(s):

Potassium Channels ◽

Neuromuscular Transmission

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COVID-19 in a Cohort of Patients with Congenital Myasthenic Syndrome

Journal of Neuromuscular Diseases ◽

10.3233/jnd-210699 ◽

2021 ◽

pp. 1-3

Author(s):

Setareh Alabaf ◽

Karen O'Connell ◽

Sithara Ramdas ◽

David Beeson ◽

Jacqueline Palace

Keyword(s):

High Risk ◽

Neuromuscular Transmission ◽

Genetic Disorders ◽

Severe Disease ◽

Congenital Myasthenic Syndrome ◽

Referral Centre ◽

History Of ◽

Myasthenic Syndrome ◽

The Uk ◽

Rare Group

Congenital Myasthenic Syndrome (CMS) are a rare group of genetic disorders of neuromuscular transmission. Some subtypes of CMS can be associated with respiratory and bulbar weakness and these patients may therefore be at high risk of developing a severe disease from COVID-19. We screened 73 patients with genetically confirmed CMS who were attending the UK national referral centre for evidence of previous Severe Acute Respiratory Syndrome Corona Virus 2 infection and their clinical outcome. Of 73 patients, seven had history of confirmed COVID-19. None of the infected patients developed a severe disease, and there were no signals that CMS alone carries a high risk of severe disease from COVID-19.

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Neuromuscular Transmission

Keynes & Aidley's Nerve and Muscle ◽

10.1017/9781108860789.008 ◽

2020 ◽

pp. 88-105

Keyword(s):

Neuromuscular Transmission

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Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

Brain Sciences ◽

10.3390/brainsci11081035 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1035

Author(s):

Maria Pia Giannoccaro ◽

Patrizia Avoni ◽

Rocco Liguori

Keyword(s):

Potassium Channels ◽

Neuromuscular Junction ◽

Calcium Channels ◽

Myasthenia Gravis ◽

Neuromuscular Transmission ◽

Voltage Gated ◽

Voltage Gated Calcium Channels ◽

Immune Mediated ◽

Recent Developments ◽

Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

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