p-Toluenesulfonic Acid–Celite as a Reagent for Synthesis of Esters of Alkylphosphonic Acids under Solvent-Free Conditions

2007 ◽  
Vol 2007 (6) ◽  
pp. 328-331 ◽  
Author(s):  
Arvind K. Gupta ◽  
Rajesh Kumar ◽  
Devendra K. Dubey ◽  
M.P. Kaushik
Keyword(s):  
Chemical Warfare Agents ◽  
Coupling Reaction ◽  
Chemical Warfare ◽  
Solvent Free ◽  
Rapid Synthesis ◽  
Toluenesulfonic Acid ◽  
Solvent Free Conditions ◽  
Warfare Agents ◽  
Alkylphosphonic Acids

The coupling reaction of alkylphosphonic acids and alcohols on the surface of p-toluenesulfonic acid–Celite under mild and solvent-free conditions gave the corresponding phosphonates in excellent yields. This method provides a useful rapid synthesis of phosphonates for use in the unambiguous identification of chemical warfare agents.

Microwave Induced Synthesis of O,O-Dialkyl Dialkylpyrophosphonates under Solvent Free Conditions: Markers of Nerve Agents

2008 ◽  
Vol 61 (6) ◽  
pp. 476 ◽  
Author(s):  
Rajesh Kumar ◽  
Deepak Pardasani ◽  
Avik Mazumder ◽  
Devendra K. Dubey ◽  
Arvind K. Gupta
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Solvent Free ◽  
High Yield ◽  
Microwave Assisted Synthesis ◽  
Phosphonium Salts ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Warfare Agents ◽  
Operational Simplicity

This article describes a one pot, solvent free, microwave assisted synthesis of O,O-dialkyl dialkylpyrophosphonates (DADAPP) from O-alkyl alkylphosphonic chlorides 2a–j with 4-dimethylaminopyridine (DMAP) in the presence of water under microwave irradiation. The reaction takes place by the phosphonium salts, which are converted into the DADAPPs 4a–j. These DADAPPs are important markers of chemical warfare agents sarin, soman, and VX and their analogues. The method has several advantages over the conventional methods such as operational simplicity, high yield, and reduced reaction time.

NEUROLOGICAL FEATURES IN CHILDREN AND DIPHENYLARSINIC ACID PROBABLY DERIVED FROM CHEMICAL WARFARE AGENTS

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
N Iwasaki ◽  
S Miyamoto ◽  
K Ishii ◽  
T Takeda ◽  
T Ohto ◽  
...  
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Warfare Agents ◽  
Neurological Features
Sign in / Sign up

Export Citation Format

Share Document