Synthesis of 3-[(acetylamino)(aryl)methyl]-4-Hydroxycoumarins

2007 ◽  
Vol 2007 (9) ◽  
pp. 535-537 ◽  
Author(s):  
Mohammad Anary-Abbasinejad ◽  
Hossein Anaraki-Ardakani ◽  
Azimeh Saidipoor ◽  
Mahmood Shojaee
Keyword(s):  
Chlorosulfonic Acid ◽  
One Pot ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
Aryl Methyl

One-pot, three-component reaction between aryl aldehydes, 4-hydroxycoumarin, and acetonitrile in the presence of chlorosulfonic acid affords 3-[(acetylamino)(aryl)methyl]-4-hydroxycoumarins in excellent yields.

PTSA-Catalyzed One Pot Domino Synthesis of Dihydropyrido[2,3-d]pyrimidine Derivatives and their Antimicrobial Activity

2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
In Vitro Antimicrobial Activity ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
The One

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.

Three-component reaction between 2-naphthol, aromatic aldehydes and acetonitrile in the presence of chlorosulfonic acid yields 1-(acetylamino(aryl)methyl)-2-naphthols

2007 ◽  
Vol 2007 (11) ◽  
pp. 644-646 ◽  
Author(s):  
Mohammad Anary-Abbasinejad ◽  
Alireza Hassanabadi ◽  
Maryam Kamali-Gharamaleki ◽  
Azimeh Saidipoor ◽  
Hossein Anaraki-Ardakani
Keyword(s):  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Three Component Reaction ◽  
Aryl Methyl

ChemInform Abstract: Three-Component Reaction Between 2-Naphthol, Aromatic Aldehydes and Acetonitrile in the Presence of Chlorosulfonic Acid Yields 1-(Acetylamino(aryl)methyl)-2-naphthols.

ChemInform ◽  
2008 ◽  
Vol 39 (20) ◽  
Author(s):  
Mohammad Anary-Abbasinejad ◽  
Alireza Hassanabadi ◽  
Maryam Kamali-Gharamaleki ◽  
Azimeh Saidipoor ◽  
Hossein Anaraki-Ardakani
Keyword(s):  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Three Component Reaction ◽  
Aryl Methyl

One-pot synthesis of 1-(benzothiazolylamino)aryl methyl-2-naphthols and 3-benzothiazolyl 2,3-dihydroquinazolinones using a magnetically recoverable core–shell nanocomposite as catalyst

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yousef Mardani ◽  
Zahed Karimi-Jaberi ◽  
Mohammad Jaafar Soltanian Fard
Keyword(s):  
Reaction Times ◽  
Chemical Waste ◽  
One Pot ◽  
Significant Deterioration ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Green Conditions ◽  
Aryl Methyl ◽  
Operational Simplicity

Abstract Nano-magnetite-supported sulfated polyethylene glycol (Fe3O4@PEG-SO3H) was prepared, characterized and utilized as a magnetically recoverable heterogeneous catalyst for the one-pot, three-component reaction of 2-aminobenzothiazole, aldehydes and 2-naphthol/isatoic anhydride resulting in efficient formation of 1-(benzothiazolylamino)arylmethyl-2-naphthol or dihydroquinazolinones derivatives. The significant features of this method include green conditions, operational simplicity, minimizing production of chemical waste, shorter reaction times and good to high yields. In addition, the nanocatalyst can easily be separated from the reaction mixture by application of a magnetic field and reused without significant deterioration in its catalytic activity.

scholarly journals Efficient, One-Pot Synthesis of Tetrahydrobenzo[a]xanthen-11-ones and Dibenzo[a,j]xanthenes Using Trichloroacetic Acid as a Solid Heterogeneous Catalyst Under Solvent-Free Conditions

2011 ◽  
Vol 8 (4) ◽  
pp. 1895-1899 ◽  
Author(s):  
Zahed Karimi Jaber ◽  
S. Zoleykha Abbasi ◽  
Baharak Pooladian ◽  
Marziyeh Jokar
Keyword(s):  
Heterogeneous Catalyst ◽  
Efficient Method ◽  
Trichloroacetic Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Aryl Aldehydes ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
Free Media

A simple and efficient method have been described for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives employing a one-pot, three-component reaction of aryl aldehydes, 2-naphthol and dimedone in the presence of trichloroacetic acid under solvent-free conditions. Also the condensation of 2-naphthol with alkyl or aryl aldehydes in the presence of trichloroacetic acid under solvent-free media to afford the corresponding 14-aryl or alkyl -14H-dibenzo [a.j]xanthenes in excellent yields and short reaction times is described.

scholarly journals Ultrasound-promoted synthesis of novel dihydropyrido[2,3-d:5,6- d`]dipyrimidine derivatives

2015 ◽  
Vol 11 (5) ◽  
pp. 3567-3575
Author(s):  
Manouchehr Mamaghani
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Mixed Solvent ◽  
Reaction Times ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
High Yields

An efficient synthesis of dihydropyrido[2,3-d:5,6-d`]pyrimidine derivatives was developed via one-pot three-component reaction of 6-amino-2-(alkylthio)-pyrimidine-4(3H)one and aryl aldehydes in the mixed solvent of glacial acetic acid and DMF (1:1, v:v) under ultrasonic irradiation. In this protocol novel fused dihydropyrido[2,3-d]pyrimidines were synthesized in high yields (80-97%) and lower reaction times (5-25 min).

scholarly journals Microwave-assisted High Diastereoselective Synthesis of α-Aminophosphonates under Solvent and Catalyst Free-conditions

2017 ◽  
Vol 56 (2) ◽  
Author(s):  
Gaurao D. Tibhe ◽  
Miguel Angel Reyes-González ◽  
Carlos Cativiela ◽  
Mario Ordóñez
Keyword(s):  
Large Scale ◽  
Diastereoselective Synthesis ◽  
One Pot ◽  
Dimethyl Phosphite ◽  
Aryl Aldehydes ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
Short Time ◽  
General Method

A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophosphonates through “one-pot” three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of α-aminophosphonates in short reaction time

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