scholarly journals Stem cell therapy for Parkinson's disease

2004 ◽  
Vol 6 (3) ◽  
pp. 303-311
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Clinical Practice ◽  
Side Effects ◽  
Cell Biology ◽  
Symptomatic Relief ◽  
Stem Cell Biology ◽  
Biological Parameters ◽  
And Control

Transplantation of human fetal dopamine (DA) neurons to patients with Parkinson's disease (PD) has given proof of the principle that new neurons can survive for at least a decade, and then functionally integrate and provide significant symptomatic relief. Unfortunately, the ethical, technical, and practical limitations of using fetal DA neurons as the source for cell transplantation in PD, in combination with the development of unwanted grafting-related side effects, have put a halt to the spread of this treatment into clinical practice. Hopefully, recent advances in the fields of stem cell biology and adult neurogenesis research will lead totamen in new exciting ways to better understand and control the biological parameters necessary for achieving safe and successful neuronal replacement in PD patients.

Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s disease.

2021 ◽  
Vol 20 ◽  
Author(s):  
Yogita Sharma ◽  
Shobha K ◽  
Mata Sundeep ◽  
Venkata Bharatkumar Pinnelli ◽  
Shagufta Parveen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Dental Pulp ◽  
Symptomatic Relief ◽  
Dental Pulp Stem Cells ◽  
Neural Basis ◽  
Current Therapies ◽  
Better Than

: Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. Though significant insights into the molecular-biochemical-cellular-behavioral basis of PD have been understood, there is no appreciable treatment available till date. Current therapies provide symptomatic relief without any influence on the progression of the disease. Stem cell therapy has been vigorously explored to treat PD. In this comprehensive review, we analyze various stem cell candidates for treating PD and discuss the possible mechanisms. We advocate the advantage of using neural crest originated dental pulp stem cells (DPSC) due to their predisposition towards neural differentiation and their potential to regenerate neurons far better than commonly used bone marrow derived mesenchymal stem cells (BM-MSCs). Eventually, we highlight the current challenges in the field and the strategies which may be used for overcoming the impediments.

scholarly journals Expected applications of the endometrial stem cells in clinical practice

2015 ◽  
Vol 64 (6) ◽  
pp. 68-77 ◽  
Author(s):  
Elena Olegovna Usoltceva ◽  
Alexander Mkrtichevich Gzgzyan ◽  
Liailia Kharryasovna Dzhemlikhanova ◽  
Dariko Aleksandrovna Niauri
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Clinical Practice ◽  
Cell Biology ◽  
Therapeutic Potential ◽  
Cell Engineering ◽  
Stem Cell Biology ◽  
Biological Basis ◽  
Endometrial Stem Cells

Recent findings in stem cell biology and cell engineering cannot be left without physicians’ attention. Endometrium as actively regenerating tissue represents also a source of endometrial stem cells. Endometrial stem cells have specific properties that distinguish them from other somatic stem cells. Endometrial stem cells have already shown their therapeutic efficiency and safety in a number of experimental and clinical trials. The biological basis of endometrial stem cells therapeutic potential and recent data on their use in clinical practice are discussed in the article.

Stem cell deficiency in Parkinson's disease

2005 ◽  
Vol 32 (06) ◽  
Author(s):  
GU Höglinger ◽  
P Rizk ◽  
WH Oertel ◽  
EC Hisch
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell
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