A case of mitral valve plastics in the early postoperative period after orthotopic heart transplantation

Today, heart transplantation is a gold standard treatment of the terminal chronic heart failure. Despite the constant improvement of the technique of this operation and the emergence of new protocols of immunosuppressive therapy, one of the main problems in the development of heart transplantation in Ukraine is a limited donor pool. The article presents a clinical case of successful orthotopic heart transplantation, followed by mitral valve repair in the early postoperative period. Our experience shows that mitral valve repair after orthotopic heart transplantation provides good results in the medium term, and this type of intervention can potentially expand the donor pool, thus increasing the number of heart transplants. Key words: chronic heart failure, heart transplantation, mitral valve repair.

Download Full-text

Heart transplantation and mitral valve repair in pediatric patients with refractory heart failure

Transplantation Proceedings ◽

10.1016/s0041-1345(02)03985-4 ◽

2003 ◽

Vol 35 (1) ◽

pp. 463-465 ◽

Cited By ~ 4

Author(s):

S.-S Wang ◽

R.-B Hsu ◽

Y.-S Chen ◽

W.-J Ko ◽

N.-K Chou ◽

...

Keyword(s):

Heart Failure ◽

Mitral Valve ◽

Heart Transplantation ◽

Mitral Valve Repair ◽

Pediatric Patients ◽

Valve Repair ◽

Refractory Heart Failure

Download Full-text

Hemodynamic Effects of Interventional Edge-to-Edge Mitral Valve Repair in Patients with End-Stage Heart Failure Awaiting Heart Transplantation

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0038-1627926 ◽

2018 ◽

Vol 66 (S 01) ◽

pp. S1-S110

Author(s):

N. Geis ◽

S. Pleger ◽

R. Bekeredjian ◽

E. Chorianopoulos ◽

L. Frankenstein ◽

...

Keyword(s):

Heart Failure ◽

Mitral Valve ◽

Heart Transplantation ◽

Mitral Valve Repair ◽

Hemodynamic Effects ◽

Valve Repair ◽

End Stage Heart Failure ◽

End Stage

Download Full-text

Contrasting Effects of Pharmacological, Procedural, and Surgical Interventions on Proportionate and Disproportionate Functional Mitral Regurgitation in Chronic Heart Failure

Circulation ◽

10.1161/circulationaha.119.039612 ◽

2019 ◽

Vol 140 (9) ◽

pp. 779-789 ◽

Cited By ~ 20

Author(s):

Milton Packer ◽

Paul A. Grayburn

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Mitral Valve ◽

Mitral Regurgitation ◽

Mitral Valve Repair ◽

Cardiac Resynchronization ◽

Functional Mitral Regurgitation ◽

Valve Repair ◽

Transcatheter Mitral Valve Repair ◽

Lv Volumes

Two distinct pathways can lead to functional mitral regurgitation (MR) in patients with chronic heart failure and a reduced ejection fraction. When remodeling and enlargement of the left ventricle (LV) cause annular dilatation and tethering of the mitral valve leaflets, there is a linear relationship between LV end-diastolic volume and the effective regurgitant orifice area of the mitral valve. These patients, designated as having proportionate MR, respond favorably to treatments that lead to reversal of LV remodeling and a decrease in LV volumes (eg, neurohormonal antagonists and LV assist devices), but they may not benefit from interventions that are directed only at the mitral valve leaflets (eg, transcatheter mitral valve repair). In contrast, when ventricular dyssynchrony causes functional MR attributable to unequal contraction of the papillary muscles, the magnitude of regurgitation is greater than that predicted by LV volumes. These patients, designated as having severe but disproportionate MR, respond favorably to treatments that are directed to the mitral valve leaflets or their supporting structures (eg, cardiac resynchronization or transcatheter mitral valve repair), but they may derive little benefit from interventions that act only to reduce LV cavity size (eg, pharmacological treatments). This novel conceptual framework reflects the important interplay between LV geometry and mitral valve function in determining the clinical presentation of patients, and it allows characterization of the determinants of functional MR to guide the most appropriate therapy in the clinical setting.

Download Full-text