scholarly journals Highly Pathogenic Avian Influenza A(H5N1) Virus in Wild Red Foxes, the Netherlands, 2021

2021 ◽  
Vol 27 (11) ◽  
pp. 2960-2962
Author(s):  
Jolianne M. Rijks ◽  
Hanna Hesselink ◽  
Pim Lollinga ◽  
Renee Wesselman ◽  
Pier Prins ◽  
...  
2017 ◽  
Vol 23 (12) ◽  
pp. 2050-2054 ◽  
Author(s):  
Erik Kleyheeg ◽  
Roy Slaterus ◽  
Rogier Bodewes ◽  
Jolianne M. Rijks ◽  
Marcel A.H. Spierenburg ◽  
...  

2020 ◽  
Vol 33 (1) ◽  
pp. 124-128
Author(s):  
Tanjin T. Mumu ◽  
Mohammed Nooruzzaman ◽  
Azmary Hasnat ◽  
Rokshana Parvin ◽  
Emdadul H. Chowdhury ◽  
...  

A mixed-aged flock of 130 turkeys in Bangladesh reported the sudden death of 1 bird in September 2017. Highly pathogenic avian influenza A(H5N1) virus was detected in 3 turkeys, and phylogenetic analysis placed the viruses in the reassortant clade 2.3.2.1a. The birds had clinical signs of depression, diarrhea, weakness, closed eyes, and finally death. The mortality rate of the flock was 13% over the 6 d prior to the flock being euthanized. At autopsy, we observed congestion in lungs and brain, hemorrhages in the trachea, pancreas, breast muscle, coronary fat, intestine, bursa of Fabricius, and kidneys. Histopathology revealed hemorrhagic pneumonia, hemorrhages in the liver and kidneys, and hemorrhages and necrosis in the spleen and pancreas. Significant changes in the brain included gliosis, focal encephalomalacia and encephalitis, and neuronophagia.


PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73200 ◽  
Author(s):  
Sharifa Nasreen ◽  
Salah Uddin Khan ◽  
Eduardo Azziz-Baumgartner ◽  
Kathy Hancock ◽  
Vic Veguilla ◽  
...  

2018 ◽  
Vol 24 (4) ◽  
pp. 770-773 ◽  
Author(s):  
Nancy Beerens ◽  
Guus Koch ◽  
Rene Heutink ◽  
Frank Harders ◽  
D.P. Edwin Vries ◽  
...  

2017 ◽  
Vol 23 (12) ◽  
pp. 1974-1981 ◽  
Author(s):  
Nancy Beerens ◽  
Rene Heutink ◽  
Saskia A. Bergervoet ◽  
Frank Harders ◽  
Alex Bossers ◽  
...  

2009 ◽  
Vol 46 (5) ◽  
pp. 971-976 ◽  
Author(s):  
D. Van Riel ◽  
J. M. A. Van Den Brand ◽  
V. J. Munster ◽  
T. M. Besteboer ◽  
R. A. M. Fouchier ◽  
...  

The largest recorded outbreak of highly pathogenic avian influenza virus of the subtype H7N7 occurred in the Netherlands in 2003. We describe the immunohistochemical and histopathologic findings of 3 chickens naturally infected during this outbreak. Influenza virus antigen occurred in endothelial cells and mononuclear cells of all tissues examined and occurred in parenchymal cells of heart, lung, kidney, pancreas, and trachea, often associated with multifocal inflammation and necrosis. These findings are consistent with the acute stage of highly pathogenic avian influenza from other subtypes. In the severely edematous wattle skin, most endothelial cells contained virus antigen, while in all other tissues virus antigen was only detected in a few endothelial cells. Virus histochemistry showed that this H7N7 virus attached to more endothelial cells in wattle skin than in other vascular beds. This might explain, at least partly, the tropism of the virus and the associated severity of lesions in this tissue.


2017 ◽  
Vol 216 (suppl_4) ◽  
pp. S520-S528 ◽  
Author(s):  
Apurba Chakraborty ◽  
Mahmudur Rahman ◽  
M Jahangir Hossain ◽  
Salah Uddin Khan ◽  
M Sabbir Haider ◽  
...  

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xinhua Chen ◽  
Wei Wang ◽  
Yan Wang ◽  
Shengjie Lai ◽  
Juan Yang ◽  
...  

Abstract Background Highly pathogenic avian influenza A(H5N1) virus poses a global public health threat given severe and fatal zoonotic infections since 1997 and ongoing A(H5N1) virus circulation among poultry in several countries. A comprehensive assessment of the seroprevalence of A(H5N1) virus antibodies remains a gap and limits understanding of the true risk of A(H5N1) virus infection. Methods We conducted a systematic review and meta-analysis of published serosurveys to assess the risk of subclinical and clinically mild A(H5N1) virus infections. We assessed A(H5N1) virus antibody titers and changes in titers among populations with variable exposures to different A(H5N1) viruses. Results Across studies using the World Health Organization-recommended seropositive definition, the point estimates of the seroprevalence of A(H5N1) virus-specific antibodies were higher in poultry-exposed populations (range 0–0.6%) and persons exposed to both human A(H5N1) cases and infected birds (range 0.4–1.8%) than in close contacts of A(H5N1) cases or the general population (none to very low frequencies). Seroprevalence was higher in persons exposed to A(H5N1) clade 0 virus (1.9%, range 0.7–3.2%) than in participants exposed to other clades of A(H5N1) virus (range 0–0.5%) (p < 0.05). Seroprevalence was higher in poultry-exposed populations (range 0–1.9%) if such studies utilized antigenically similar A(H5N1) virus antigens in assays to A(H5N1) viruses circulating among poultry. Conclusions These low seroprevalences suggest that subclinical and clinically mild human A(H5N1) virus infections are uncommon. Standardized serological survey and laboratory methods are needed to fully understand the extent and risk of human A(H5N1) virus infections.


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