HbF-promoting polymorphisms may specifically reduce the residual risk of cerebral vasculopathy in SCA children with alpha-thalassemia

2020 ◽  
pp. 1-6
Author(s):  
Philippe Joly ◽  
Nathalie Bonello-Palot ◽  
Catherine Badens ◽  
Serge Pissard ◽  
Abdourahim Chamouine ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Blood Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Quantitative Trait ◽  
Genetic Modifiers ◽  
Cell Deformability ◽  
Cell Rheology ◽  
Alpha Thalassemia ◽  
Hbf Level

Sickle cell anemia (SCA) is a disease characterized by abnormal red blood cell rheology. Because of their effects on HbS polymerization and red blood cell deformability, alpha-thalassemia and the residual HbF level are known genetic modifiers of the disease. The aim of our study was to determine if the number of HbF quantitative trait loci (QTL) would also favor a specific sub-phenotype of SCA as it is the case for alpha-thalassemia. Our results confirmed that alpha-thalassemia protected from cerebral vasculopathy but increased the risk for frequent painful vaso-occlusive crises. We also showed that more HbF-QTL may provide an additional and specific protection against cerebral vasculopathy but only for children with alpha-thalassemia (-α/αα or -α/-α genotypes).

Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties

2014 ◽  
Vol 57 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Yann Lamarre ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
Marie-Dominique Hardy-Dessources ◽  
Vanessa Tarer ◽  
...  
Keyword(s):  
Blood Cell ◽  
Rheological Properties ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Alpha Thalassemia

Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia

2016 ◽  
Vol 62 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Céline Renoux ◽  
Nermi Parrow ◽  
Camille Faes ◽  
Philippe Joly ◽  
Max Hardeman ◽  
...  
Keyword(s):  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154866 ◽  
Author(s):  
Kizzy-Clara Cita ◽  
Laurent Brureau ◽  
Nathalie Lemonne ◽  
Marie Billaud ◽  
Philippe Connes ◽  
...  
Keyword(s):  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Cell Aggregate ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Aggregate Strength

scholarly journals Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?

Blood ◽  
2013 ◽  
Vol 121 (15) ◽  
pp. 3054-3056 ◽  
Author(s):  
Nathalie Lemonne ◽  
Yann Lamarre ◽  
Marc Romana ◽  
Martin Mukisi-Mukaza ◽  
Marie-Dominique Hardy-Dessources ◽  
...  
Keyword(s):  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Combined and differential effects of alpha‐thalassemia and HbF‐quantitative trait loci in Senegalese hydroxyurea‐free children with sickle cell anemia

2019 ◽  
Author(s):  
Fatou Gueye Tall ◽  
Cyril Martin ◽  
El Hadji Malick Ndour ◽  
Céline Renoux ◽  
Indou Déme Ly ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Quantitative Trait ◽  
Differential Effects ◽  
Alpha Thalassemia ◽  
Trait Loci

scholarly journals Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia

Haematologica ◽  
2015 ◽  
Vol 100 (10) ◽  
pp. e383-e386 ◽  
Author(s):  
N. Lemonne ◽  
K. Charlot ◽  
X. Waltz ◽  
S. K. Ballas ◽  
Y. Lamarre ◽  
...  
Keyword(s):  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Cell Rheology ◽  
Increase Blood Viscosity ◽  
Hydroxyurea Treatment

Red blood cell nitric oxide synthase modulates red blood cell deformability in sickle cell anemia

2016 ◽  
Vol 64 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Anaïs Mozar ◽  
Philippe Connes ◽  
Bianca Collins ◽  
Marie-Dominique Hardy-Dessources ◽  
Marc Romana ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Oxide Synthase

Quantitative trait loci for red blood cell traits in swine

2007 ◽  
Vol 38 (5) ◽  
pp. 447-452 ◽  
Author(s):  
G. Reiner ◽  
R. Fischer ◽  
S. Hepp ◽  
T. Berge ◽  
F. Köhler ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Quantitative Trait ◽  
Trait Loci

In vitro effects of temperature on red blood cell deformability and membrane stability in human and various vertebrate species

2021 ◽  
pp. 1-10
Author(s):  
Adam Attila Matrai ◽  
Gabor Varga ◽  
Bence Tanczos ◽  
Barbara Barath ◽  
Adam Varga ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Mechanical Stability ◽  
Cell Deformability ◽  
Blood Samples ◽  
Effects Of Temperature ◽  
The Way ◽  
Rbc Deformability

BACKGROUND: The effects of temperature on micro-rheological variables have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of heat treatment in human, rat, dog, and porcine blood samples. METHODS: Red blood cell (RBC) - buffer suspensions were prepared and immersed in a 37, 40, and 43°C heat-controlled water bath for 10 minutes. Deformability, as well as mechanical stability of RBCs were measured in ektacytometer. These tests were also examined in whole blood samples at various temperatures, gradually between 37 and 45°C in the ektacytometer. RESULTS: RBC deformability significantly worsened in the samples treated at 40 and 43°C degrees, more expressed in human, porcine, rat, and in smaller degree in canine samples. The way of heating (incubation vs. ektacytometer temperation) and the composition of the sample (RBC-PBS suspension or whole blood) resulted in the different magnitude of RBC deformability deterioration. Heating affected RBC membrane (mechanical) stability, showing controversial alterations. CONCLUSION: Significant changes occur in RBC deformability by increasing temperature, showing inter-species differences. The magnitude of alterations is depending on the way of heating and the composition of the sample. The results may contribute to better understanding the micro-rheological deterioration in hyperthermia or fever.

scholarly journals Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Marie-Eve Myrand-Lapierre ◽  
Xiaoyan Deng ◽  
Richard R. Ang ◽  
Kerryn Matthews ◽  
Aline T. Santoso ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Heterogeneous Sample ◽  
Red Blood Cell Deformability

Mechanism for multiplexed measurement of single red blood cell deformability to evaluate pathological cells in a heterogeneous sample.

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