Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

2019 ◽  
Vol 68 (4) ◽  
pp. 1677-1686 ◽  
Author(s):  
Yoshiyuki Soeda ◽  
Marino Saito ◽  
Sumihiro Maeda ◽  
Kohki Ishida ◽  
Akira Nakamura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Methylene Blue ◽  
Tau Oligomers ◽  
Tau Fibrils

P2-027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2-NGF GENE THERAPY FOR ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P677-P677
Author(s):  
Michael J. Castle ◽  
Fernando Calvo Baltanas ◽  
Imre Kovacs ◽  
Alan H. Nagahara ◽  
Krystof S. Bankiewicz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Gene Therapy ◽  
Phase Ii ◽  
Phase Ii Clinical Trial ◽  
Target Engagement ◽  
Ngf Gene

Methylene blue and Alzheimer's disease

2009 ◽  
Vol 78 (8) ◽  
pp. 927-932 ◽  
Author(s):  
Murat Oz ◽  
Dietrich E. Lorke ◽  
George A. Petroianu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Methylene Blue

P4-045: Longitudinal ADC changes in Alzheimer's disease in a multi-center clinical trial setting

2011 ◽  
Vol 7 ◽  
pp. S713-S713
Author(s):  
Luc Bracoud ◽  
Angelika Caputo ◽  
Chahin Pachai ◽  
Boubakeur Belaroussi ◽  
Ana Graf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Clinical Trial Setting ◽  
Trial Setting

scholarly journals A clinical trial to validate event‐related potential markers of Alzheimer's disease in outpatient settings

2015 ◽  
Vol 1 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Marco Cecchi ◽  
Dennis K. Moore ◽  
Carl H. Sadowsky ◽  
Paul R. Solomon ◽  
P. Murali Doraiswamy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Event Related Potential ◽  
Outpatient Settings

scholarly journals O4-06-05: PF-04447943: A phase II controlled clinical trial of a selective PDE9A inhbitor in Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S695-S695 ◽  
Author(s):  
Elias Schwam ◽  
Rebecca Evans ◽  
Timothy Nicholas ◽  
Robert Chew ◽  
Wendy Davidson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Phase Ii ◽  
Controlled Clinical Trial
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