scholarly journals Association of White Matter Hyperintensity Progression with Cognitive Decline in Patients with Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 80 (2) ◽  
pp. 877-883
Author(s):  
Kentaro Hirao ◽  
Fumio Yamashita ◽  
Akito Tsugawa ◽  
Rieko Haime ◽  
Raita Fukasawa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensity ◽  
Final Visit ◽  
Amnestic Mci ◽  
Entire Duration ◽  
Frontal Lobe Function ◽  
State Examination

Background: White matter hyperintensities (WMH) on MRI have been reported to increase the risk of conversion from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). However, effects of the progression of WMH on the cognition of patients with MCI remains unclear to date. Objective: To investigate the association between WMH progression and cognitive decline in amnestic MCI patients. Methods: Thirty-eight subjects with amnestic MCI were analyzed prospectively every year for 2 years. Fourteen MCI subjects dropped out on the final visit, and therefore 24 subjects with MCI were analyzed for the entire duration. The volumes of periventricular hyperintensities (PVH) and deep WMH (DWMH) were measured on T2 FLAIR using the 3D-slicer. The associations between PVH/DWMH progression and cognitive decline were investigated. Results: An increase in DWMH volume significantly correlated with changes in Mini-Mental State Examination and category verbal fluency scores, whereas an increase in PVH volume did not correlate with changes in any item. Conclusion: DWMH progression was closely associated with a decline in frontal lobe function and semantic memory, suggesting that WMH progression might affect some AD pathophysiologies in amnestic MCI patients.

scholarly journals Increased regional white matter hyperintensity volume in objectively‐defined subtle cognitive decline and mild cognitive impairment

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Amanda T. Calcetas ◽  
Kelsey R. Thomas ◽  
Emily C. Edmonds ◽  
Sophia L. Holmqvist ◽  
Lauren Edwards ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensity

Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment

2018 ◽  
Vol 66 (2) ◽  
pp. 533-549 ◽  
Author(s):  
Ashwati Vipin ◽  
Heidi Jing Ling Foo ◽  
Joseph Kai Wei Lim ◽  
Russell Jude Chander ◽  
Ting Ting Yong ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Grey Matter ◽  
White Matter Hyperintensity ◽  
Grey Matter Atrophy

scholarly journals The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years

2020 ◽  
Vol 9 (8) ◽  
pp. 2663
Author(s):  
Seung Joo Kim ◽  
Dong Kyun Lee ◽  
Young Kyoung Jang ◽  
Hyemin Jang ◽  
Si Eun Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Cognitive Decline ◽  
Dynamic Change ◽  
Surrogate Marker ◽  
Brain Magnetic Resonance Imaging ◽  
Longitudinal Change ◽  
White Matter Hyperintensity ◽  
Cortical Thinning ◽  
Automated Method

White matter hyperintensity (WMH) has been recognised as a surrogate marker of small vessel disease and is associated with cognitive impairment. We investigated the dynamic change in WMH in patients with severe WMH at baseline, and the effects of longitudinal change of WMH volume on cognitive decline and cortical thinning. Eighty-seven patients with subcortical vascular mild cognitive impairment were prospectively recruited from a single referral centre. All of the patients were followed up with annual neuropsychological tests and 3T brain magnetic resonance imaging. The WMH volume was quantified using an automated method and the cortical thickness was measured using surface-based methods. Participants were classified into WMH progression and WMH regression groups based on the delta WMH volume between the baseline and the last follow-up. To investigate the effects of longitudinal change in WMH volume on cognitive decline and cortical thinning, a linear mixed effects model was used. Seventy patients showed WMH progression and 17 showed WMH regression over a three-year period. The WMH progression group showed more rapid cortical thinning in widespread regions compared with the WMH regression group. However, the rate of cognitive decline in language, visuospatial function, memory and executive function, and general cognitive function was not different between the two groups. The results of this study indicated that WMH volume changes are dynamic and WMH progression is associated with more rapid cortical thinning.

P4-184: Elevated arterial stiffness and deep-brain white matter hyperintensity in patients with mild cognitive impairment

2012 ◽  
Vol 8 (4S_Part_19) ◽  
pp. P700-P701
Author(s):  
Benjamin Tseng ◽  
Muhammad Ayaz ◽  
Estee Brunk ◽  
Kyle Armstrong ◽  
Kristin Martin-Cook ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Arterial Stiffness ◽  
White Matter Hyperintensity ◽  
Brain White Matter ◽  
Deep Brain

scholarly journals Frontal White Matter Hyperintensity Is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment

2018 ◽  
Vol 8 (1) ◽  
pp. 138-150 ◽  
Author(s):  
Noriko Ogama ◽  
Takashi Sakurai ◽  
Naoki Saji ◽  
Toshiharu Nakai ◽  
Shumpei Niida ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Alzheimer Disease ◽  
Frontal Lobe ◽  
Brain Atrophy ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Hyperintensity ◽  
Verbal Aggressiveness ◽  
The Impact

Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) are exhibited in most patients with Alzheimer disease (AD). Although white matter hyperintensity (WMH) is often observed with AD, the precise role of WMH in BPSD remains unclear. The current study aimed to identify the impact of regional WMH on specific features of BPSD in persons with mild to moderate AD and amnestic mild cognitive impairment (aMCI). Methods: A sample of 256 female outpatients with AD (n = 217) and aMCI (n = 39) were recruited. We assessed BPSD using the Dementia Behavior Disturbance Scale. WMH and brain atrophy were evaluated using an automatic segmentation program. Regional WMH was evaluated as periventricular hyperintensity (PVH) and deep WMH in frontal, temporal, occipital, and parietal lobes. Results: Whole-brain WMH was associated with verbal aggressiveness. In multivariate analysis, PVH in the frontal lobe was independently associated with verbal aggressiveness after adjustment for brain atrophy and clinical confounders. Conclusion: The current results indicated that PVH in the frontal lobe was independently associated with verbal aggressiveness.

scholarly journals Trajectory of white matter hyperintensity burden preceding mild cognitive impairment

Neurology ◽  
2012 ◽  
Vol 79 (8) ◽  
pp. 741-747 ◽  
Author(s):  
L. C. Silbert ◽  
H. H. Dodge ◽  
L. G. Perkins ◽  
L. Sherbakov ◽  
D. Lahna ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensity

Acceleration of White Matter Hyperintensity Burden Preceding Onset of Mild Cognitive Impairment (S24.006)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S24.006-S24.006
Author(s):  
L. Silbert ◽  
H. Dodge ◽  
L. Perkins ◽  
D. Lahna ◽  
J. Kaye
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensity
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