Respiratory Disorders in Parkinson’s Disease

2021 ◽  
pp. 1-18
Author(s):  
Evelyn M. Guilherme ◽  
Roberta de Fátima C.M. Padovez ◽  
Adriele de Oliveira ◽  
Alyne Montero Ferro ◽  
Valéria A. P. di Lorenzo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Pulmonary Function ◽  
Respiratory Muscle ◽  
Physical Capacity ◽  
Respiratory Muscle Strength ◽  
Respiratory Impairment ◽  
Respiratory Disorders ◽  
Electronic Search

Background: Parkinson’s disease (PD) non motor symptoms may present early in the disease course and worsen with advancing disease. Respiratory changes can affect individuals to remain physically active, contributing to a reductionof functionality and quality of life. Objective: The aim of this systematic review is to synthesize evidence of respiratory disorders in patients with PD. Methods: An electronic search was performed up to November 2020 on PubMed-MEDLINE, Embase, Web of Science, Lilacs, Cinahl, and Cochrane using the following keyword combination: [(“Parkinson disease”) AND (“respiratory function tests” OR “evaluation”) AND (“respiratory system” OR “respiration disorders” OR “respiratory muscles”)]. Results: The electronic search resulted in 601 references in English or Portuguese. The selection process and data extraction were made by two independent reviewers. We selected 19 studies including cross-sectional studies that investigated the respiratory disorders in patients with PD through pulmonary function, respiratory muscle strength, or physical capacity evaluation. We excluded studies that considered patients with other diseases. Eighteen studies evaluated the pulmonary function in patients with PD, eleven studies verified the influence of PD on respiratory muscle strength, and three studies assessed the physical capacity through functional tests. Conclusion: The evidence showed that PD patients have higher chances to present a pulmonary dysfunction, either obstructive or restrictive, when compared to healthy subjects. In addition, these patients present lower respiratory muscle strength and a consequent decrease in physical capacity in endurance exercises. The respiratory impairment in PD seems to be directly related to the progression of the disease.

scholarly journals Respiratory muscle strength and lung function in the stages of Parkinson’s disease

2019 ◽  
Vol 45 (6) ◽  
Author(s):  
Rejane Barreto dos Santos ◽  
Anderson Santos Fraga ◽  
Maria das Graças Wanderley de Sales Coriolano ◽  
Bruna Ferreira Tiburtino ◽  
Otávio Gomes Lins ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Lung Function ◽  
Motor Function ◽  
Respiratory Muscle ◽  
Respiratory Muscle Strength ◽  
And Control

ABSTRACT Objective: To investigate parameters of lung function and respiratory muscle strength in different stages of Parkinson’s disease (PD), as well as to determine their correlation with motor function and quality of life. Methods: This was a cross-sectional study conducted at a referral center for PD in the city of Recife, Brazil. Respiratory muscle strength and lung function, as well as their relationship with motor function and quality of life, were evaluated in patients with PD, stratified by the level of severity, and were compared with the data obtained for a control group. After confirming the normality of data distribution, we performed one-way ANOVA with a post hoc t-test. Results: The sample comprised 66 individuals, in two groups: PD (n = 49) and control (n = 17). All of the parameters investigated showed inverse correlations with PD severity, and there were significant differences among the levels of severity, as well as between the PD and control groups, in terms of the MIP, MEP, FVC, FEV1, and FEF25-75%. The lung function parameters also showed moderate to weak inverse correlations with bradykinesia and rigidity. On a quality of life questionnaire, the total score and mobility domain score both presented a moderate inverse correlation with FVC, FEV1, PEF, and MEP. Conclusions: Respiratory muscle strength and some lung function parameters are impaired from the early stages of PD onward, bradykinesia and rigidity being the cardinal signs that correlate most strongly with impairment of those parameters. Such alterations negatively affect the quality of life of patients with PD.

scholarly journals Respiratory Muscle Performance and the Perception of Dyspnea in Parkinson's Disease

2002 ◽  
Vol 29 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Paltiel Weiner ◽  
Rivka Inzelberg ◽  
Avi Davidovich ◽  
Puiu Nisipeanu ◽  
Rasmi Magadle ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Respiratory Muscles ◽  
Normal Subjects ◽  
Forced Expiratory Volume ◽  
Muscle Performance ◽  
Respiratory Muscle Strength ◽  
Before And After

Background:Pulmonary and respiratory muscle function impairment are common in patients with Parkinson's disease (PD). However, dyspnea is not a frequent complaint among these patients, although it is well documented that the intensity of dyspnea is related to the activity and the strength of the respiratory muscles.Patients and Methods:We studied pulmonary function, respiratory muscle strength and endurance and the perception of dyspnea (POD) in 20 patients with PD (stage II and III Hoehn and Yahr scale) before and after their first daily L-dopa dose. Respiratory muscle strength was assessed by measuring the maximal inspiratory and expiratory mouth pressures (PImax and PEmax), at residual volume (RV) and total lung capacity (TLC) respectively. The POD was measured while the subject breathed against progressive load and dyspnea was rated using a visual analog scale.Results:Respiratory muscle strength and endurance were decreased and the POD was increased during the off medication period compared to normal subjects. There was a nonsignificant trend to an increase in PImax, PEmax and endurance after L-dopa intake. The POD of PD patients decreased (p<0.05) following medication, although, it remained increased (p<0.01) as compared to the normal subjects. Even if patients had spirometry data showing a mild restrictive pattern, before medication, both forced vital capacity (FVC) and forced expiratory volume (FEV)1 remained almost identical after L-dopa intake.Conclusions:Patients with PD have higher POD, compared to normal subjects and this increased perception is attenuated when the patients are on dopaminergic medication. The change in the POD is not related to changes in respiratory muscle performance or pulmonary functions. A central effect or a correction of uncoordinated respiratory movements by L-dopa may contribute to the decrease in POD following L-dopa treatment.

scholarly journals Influence of global postural reeducation method on respiratory muscle strength and parkinsonian quality of life

2020 ◽  
pp. 1-5 ◽  
Author(s):  
Larissa Salgado de Oliveira Rocha ◽  
Larissa Natsumi Hosoda Mineshita ◽  
Luciane Lobato Sobral ◽  
Lizandra Dias Magno ◽  
Marcio Clementino de Souza Santos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Post Treatment ◽  
Inspiratory Pressure ◽  
Life Questionnaire ◽  
Respiratory Muscle Strength

Background: Degenerative diseases such as Parkinson’s disease can lead to postural changes and muscular strength, this generates greater impact on the individual, on his functional capacity, respiratory system, mobility and, quality of life (QOL). Objective: The aim of this study was to verify the influence of the Global Posture Reeducation (GPR) method on respiratory muscle strength and QOL in patients with Parkinson’s disease. Methods: Twenty volunteers, the average of age is 48.8 ± 6.22 years, they are diagnosed with Parkinson’s disease at level 2 to 3 by the Hoehn & Yahr Scale. They were submitted to the protocol of treatment with the GPR method in the postures of Frog in the ground and ballerina, performed regularly twice a week lasting 60 minutes each session, for 6 weeks, totaling 12 sessions, evaluated by PDQ-39 quality of life questionnaire and by inspiratory pressure measurements and Maximum expiratory value. Results: In the quantitative analysis of inspiratory and expiratory muscle pressure, there was an increase in post-treatment for maximal inspiratory pressure (MIP) (p <0.05) when compared to pre-treatment, as well as when compared with predicted values MIP and maximum expiratory pressure (MEP) presented higher values (p <0.05). In terms of QoL domains: mobility (p = 0.0009), daily life activity (p = 0.0006), emotional well-being (p = 0.001), cognition (p = 0.01) and physical discomfort were statistically significant in post-treatment. Conclusion: The use of GPR in Parkinson’s disease has shown to be effective in the treatment of respiratory muscle strength and QoL.

scholarly journals Pulmonary Function and Respiratory Muscle Strength in Patients with Multiple Sclerosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Elisabeth Westerdahl ◽  
Martin Gunnarsson ◽  
Anna Wittrin ◽  
Ylva Nilsagård
Keyword(s):  
Multiple Sclerosis ◽  
Muscle Strength ◽  
Pulmonary Function ◽  
Lower Limit ◽  
Functional Capacity ◽  
Respiratory Muscle ◽  
Physical Capacity ◽  
Respiratory Muscle Strength ◽  
Edss Score ◽  
Lower Limit Of Normal

Background. In patients with multiple sclerosis (MS), there is a decline in muscle strength and physical capacity due to demyelination and axonal loss in the central nervous system. In patients with advanced MS or in a later stage of the disease, also respiratory impairment may occur. The degree of pulmonary dysfunction in the earlier stages of MS has not been thoroughly described. Therefore, the primary aims of this study are to describe pulmonary function and respiratory muscle strength in patients with a moderate disease course and to identify associations between respiratory muscle strength and functional capacity. Methods. A sample of 48 patients with a diagnosis of MS and mean age 56 ± 11 years was studied using a descriptive cross-sectional design. The patients had a disease duration of 24 ± 11 years and a median Expanded Disability Status Scale (EDSS) score of 4.5 (interquartile range 4.0-6.5). Pulmonary function assessed by spirometry, respiratory muscle strength, peak cough flow and peripheral oxygen saturation, subjective breathing and coughing ability, and physical capacity measured using the 6MWT were evaluated. Results. The patients had normal pulmonary function with no significant abnormalities in dynamic spirometry (vital capacity 103 ± 16 % predicted, forced expiratory volume in 1 second 95 ± 15 % predicted). Peak expiratory flow rate 89 ± 17 % predicted was in the lower limit of normal. Respiratory muscle strength, determined by maximal inspiratory (MIP) and expiratory (MEP) static pressures, was normal but with large differences between individuals. MIP ranged from 26 to 143 cmH2O ( 98 ± 31 % predicted); the MEP values ranged from 43 to 166 cmH2O ( 104 ± 29 % predicted), with two patients having values below the lower limit of normal. Significant positive associations between MIP as well as MEP were found in several pulmonary function variables. A significant negative association was found between EDSS score and MEP ( r = − 0.312 , p = 0.031 ). Mean peak cough flow was 389 ± 70  L/min, which is comparable with the values reported for healthy adults. The patients did not experience a severely decreased ability to take deep breaths or cough. There was a moderate correlation between MEP and physical capacity, as assessed by the 6MWT ( r = 0.399 , p = 0.010 ) and between peak expiratory flow (PEF) and the 6MWT ( r = 0.311 , p = 0.048 ). Conclusion. Respiratory muscle strength, pulmonary function assessed by spirometry, and peak cough flow were normal in patients with mild to moderate MS; however, there were large individual differences demonstrating low respiratory muscle strength in some patients. Significant associations between MEP and functional capacity and between MEP and disease severity were found, indicating that patients with impaired respiratory muscle strength have lower functional capacity and more severe disease.

Effects of Treatment on Airway Dynamics and Respiratory Muscle Strength in Parkinson's Disease

1993 ◽  
Vol 148 (6_pt_1) ◽  
pp. 1576-1580 ◽  
Author(s):  
Pedro F. C. De Bruin ◽  
Veralice M. S. De Bruin ◽  
Andrew J. Lees ◽  
Neil B. Pride
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Respiratory Muscle Strength ◽  
Airway Dynamics

scholarly journals Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis

2013 ◽  
Vol 71 (3) ◽  
pp. 146-152 ◽  
Author(s):  
Guilherme Fregonezi ◽  
Palomma Russelly Saldanha Araújo ◽  
Tathiana Lindemberg Ferreira Macêdo ◽  
Mario Emilio Dourado Junior ◽  
Vanessa Regiane Resqueti ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Muscle Strength ◽  
Early Diagnosis ◽  
Pulmonary Function ◽  
Healthy Subjects ◽  
Respiratory Muscle ◽  
Function Evaluation ◽  
Respiratory Muscle Strength ◽  
Respiratory Dysfunction ◽  
Lateral Sclerosis

ObjectiveIt was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects.MethodsPulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness.ResultsTwenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax.ConclusionIn ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.

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