Reduction of self-mutilating behavior and improved oromotor function in a patient with Lesch-Nyhan syndrome following botulinum toxin injection: A case report

2021 ◽  
Vol 14 (1) ◽  
pp. 133-136
Author(s):  
Courtney Gilbert ◽  
Michelle Sauer ◽  
JenFu Cheng

Lesch-Nyhan syndrome is a genetic metabolic disorder often involving dystonia and self-mutilating behavior. This case report describes a 13-year-old boy with Lesch-Nyhan syndrome and self-mutilating behavior who received botulinum toxin injections to his bilateral masseter muscles after failing multiple other treatments. Following injections, the patient had reduction in self-biting, along with improvements in speech, mastication and feeding observed in speech therapy. Botulinum toxin injections to the masseters may help to improve oromotor function and reduce self-mutilating behaviors in children with Lesch-Nyhan syndrome who have failed more conservative treatments, providing opportunity for improved functional status and patient safety. Further investigation is indicated to establish optimal dosing. Additionally, the mechanism for the reduction of self-mutilating behavior is unclear and justifies additional investigation.

2021 ◽  
Vol 9 ◽  
pp. 2050313X2199359
Author(s):  
Clare Perkins ◽  
Wei Jia ◽  
James Rainsbury ◽  
Andrew Lux

Hereditary geniospasm is a rare and benign disorder that can cause distress and social embarrassment to patients. There are only a handful of possible treatment options available. Due to the rarity of the condition, practices differ across the world and the results are varied. These include beta-blockers, benzodiazepines and anti-epileptics. These treatments can have significant side-effects when used long term. However, botulinum toxin injections have been successfully used in a handful of cases. We report a successful botulinum treatment of hereditary geniospasm in a mother and son, with the injection protocols.


2014 ◽  
Vol 51 (4) ◽  
pp. 661-664 ◽  
Author(s):  
Serdar Kesikburun ◽  
Rıdvan Alaca ◽  
Berke Aras ◽  
İlknur Tuğcu ◽  
Arif Kenan Tan

SpringerPlus ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Terrence L. Trentman ◽  
Jillian A. Maloney ◽  
Christopher S. Wie ◽  
Alanna M. Rebecca ◽  
David M. Rosenfeld

2017 ◽  
Vol 38 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Gunwoo Park ◽  
Young-Chan Choi ◽  
Jung-Hee Bae ◽  
Seong-Taek Kim

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