CYTOTOXIC ACTIVITY OF VARTHEMIA IPHIONOIDES ESSENTIAL OIL AGAINST VARIOUS HUMAN CANCER CELL LINES

Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera. Three new alkaloids, zanthocadinanine C (1), 7-methoxy-8-demethoxynitidine (2), and zanthonitiside I (3) were isolated from the stems and twigs of Z. nitidum. Their structures were determined on the basis of extensive spectroscopic, including 1-dimensional and 2-dimensional nuclear magnetic resonance and mass spectroscopy data. Compounds 1–3 were evaluated for cytotoxic activity against 5 human cancer cell lines, KB, MCF-7, LNCaP, HepG-2, and LU-1. Compound 2 showed significant cytotoxic activity against all tested human cancer cell lines with IC50 values ranging from 10.3 to 12.6 µM.

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Effect of the Method of Preparation on the Composition and Cytotoxic Activity of the Essential Oil of Pituranthos tortuosus

Zeitschrift für Naturforschung C ◽

10.1515/znc-2011-3-408 ◽

2011 ◽

Vol 66 (3-4) ◽

pp. 143-148 ◽

Cited By ~ 8

Author(s):

Hossam M. Abdallah ◽

Shahira M. Ezzat

Keyword(s):

Breast Cancer ◽

Essential Oil ◽

Cell Line ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Line ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

The aerial parts of Pituranthos tortuosus (Desf.) Benth and Hook (Apiaceae), growing wild in Egypt, yielded 0.8%, 0.6%, and 1.5% (v/w) of essential oil when prepared by hydrodistillation (HD), simultaneous hydrodistillation-solvent (n-pentane) extraction (Lickens- Nickerson, DE), and conventional volatile solvent extraction (preparation of the “absolute”, SE), respectively. GC-MS analysis showed that the major components in the HD sample were β-myrcene (18.81%), sabinene (18.49%), trans-iso-elemicin (12.90%), and terpinen- 4-ol (8.09%); those predominent in the DE sample were terpinen-4-ol (29.65%), sabinene (7.38%), γ-terpinene (7.27%), and β-myrcene (5.53%); while the prominent ones in the SE sample were terpinen-4-ol (15.40%), dill apiol (7.90%), and allo-ocimene (4E,6Z) (6.00%). The oil prepared in each case was tested for its cytotoxic activity on three human cancer cell lines, i.e. liver cancer cell line (HEPG2), colon cancer cell line (HCT116), and breast cancer cell line (MCF7). The DE sample showed the most potent activity against the three human cancer cell lines (with IC50 values of 1.67, 1.34, and 3.38 μg/ml against the liver, colon, and breast cancer cell lines, respectively). Terpinen-4-ol, sabinene, γ-terpinene, and β-myrcene were isolated from the DE sample and subjected to a similar evaluation of cytotoxic potency; signifi cant activity was observed

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ChemInform Abstract: New Synthetic Route to [Bis-1,2-(aminomethyl)benzene]dichloroplatinum(II) Complexes, Screening for Cytotoxic Activity in Cisplatin-Sensitive and Resistant Human Cancer Cell Lines, and Reaction with Glutathione.

ChemInform ◽

10.1002/chin.200152172 ◽

2010 ◽

Vol 32 (52) ◽

pp. no-no

Author(s):

K. Rinke ◽

R. Gruenert ◽

P. J. Bednarski

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Synthetic Route ◽

Human Cancer Cell Lines

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Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines

Cancer Letters ◽

10.1016/j.canlet.2003.08.023 ◽

2004 ◽

Vol 203 (1) ◽

pp. 59-69 ◽

Cited By ~ 44

Author(s):

Krzysztof Polkowski ◽

Joanna Popiołkiewicz ◽

Piotr Krzeczyński ◽

Jan Ramza ◽

Wiesław Pucko ◽

...

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

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[4-(Imidazol-1-yl)thiazol-2-yl]phenylamines. A Novel Class of Highly Potent Colchicine Site Binding Tubulin Inhibitors: Synthesis and Cytotoxic Activity on Selected Human Cancer Cell Lines

Journal of Medicinal Chemistry ◽

10.1021/jm060545p ◽

2006 ◽

Vol 49 (19) ◽

pp. 5769-5776 ◽

Cited By ~ 15

Author(s):

Siavosh Mahboobi ◽

Andreas Sellmer ◽

Heymo Höcher ◽

Emerich Eichhorn ◽

Thomas Bär ◽

...

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines ◽

Tubulin Inhibitors ◽

Site Binding

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SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A

Vietnam Journal of Science and Technology ◽

10.15625/2525-2518/54/2c/11880 ◽

2018 ◽

Vol 54 (2C) ◽

pp. 502

Author(s):

Le Duc Anh

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Hep G2 ◽

Human Cancer Cell Lines ◽

Activity Evaluation ◽

Derivatives Of

Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 wereprepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylationreactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,LU, RD and Fl. The result showed that both compounds exhibited no activity against the testedcell lines.

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