scholarly journals RNA Polyadenylation

2020 ◽  
Author(s):  
Keyword(s):  
Rna Polyadenylation

scholarly journals RNA polyadenylation and degradation in different Archaea; roles of the exosome and RNase R

2006 ◽  
Vol 34 (20) ◽  
pp. 5923-5931 ◽  
Author(s):  
Victoria Portnoy ◽  
Gadi Schuster
Keyword(s):  
Rnase R ◽  
Rna Polyadenylation

scholarly journals Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq

RNA ◽  
2011 ◽  
Vol 17 (4) ◽  
pp. 761-772 ◽  
Author(s):  
P. J. Shepard ◽  
E.-A. Choi ◽  
J. Lu ◽  
L. A. Flanagan ◽  
K. J. Hertel ◽  
...  
Keyword(s):  
Dynamic Landscape ◽  
Rna Polyadenylation

scholarly journals Landscape of RNA polyadenylation inE. coli

2016 ◽  
pp. gkw894 ◽  
Author(s):  
Alexandre Maes ◽  
Céline Gracia ◽  
Nicolas Innocenti ◽  
Kaiyang Zhang ◽  
Erik Aurell ◽  
...  
Keyword(s):  
Rna Polyadenylation

scholarly journals Maturation-specific polyadenylation and translational control: diversity of cytoplasmic polyadenylation elements, influence of poly(A) tail size, and formation of stable polyadenylation complexes.

1990 ◽  
Vol 10 (11) ◽  
pp. 5634-5645 ◽  
Author(s):  
J Paris ◽  
J D Richter
Keyword(s):  
Complex Formation ◽  
Oocyte Maturation ◽  
Translational Control ◽  
Untranslated Regions ◽  
Stable Complex ◽  
Mobility Shift ◽  
Cytoplasmic Polyadenylation ◽  
Egg Extracts ◽  
Gel Mobility Shift ◽  
Rna Polyadenylation

Early embryonic development in Xenopus laevis is programmed in part by maternally derived mRNAs, many of which are translated at the completion of meiosis (oocyte maturation). Polysomal recruitment of at least one of these mRNAs, G10, is regulated by cytoplasmic poly(A) elongation which, in turn, is dependent upon the cytoplasmic polyadenylation element (CPE) UUUUUUAUAAAG and the hexanucleotide AAUAAA (L. L. McGrew, E. Dworkin-Rastl, M. B. Dworkin, and J. D. Richter, Genes Dev. 3:803-815, 1989). We have investigated whether sequences similar to the G10 RNA CPE that are present in other RNAs could also be responsible for maturation-specific polyadenylation. B4 RNA, which encodes a histone H1-like protein, requires a CPE of the sequence UUUUUAAU as well as the polyadenylation hexanucleotide. The 3' untranslated regions of Xenopus c-mos RNA and mouse HPRT RNA also contain U-rich CPEs since they confer maturation-specific polyadenylation when fused to Xenopus B-globin RNA. Polyadenylation of B4 RNA, which occurs very early during maturation, is limited to 150 residues, and it is this number that is required for polysomal recruitment. To investigate the possible diversity of factors and/or affinities that might control polyadenylation, egg extracts that faithfully adenylate exogenously added RNA were used in competition experiments. At least one factor is shared by B4 and G10 RNAs, although it has a much greater affinity for B4 RNA. Additional experiments demonstrate that an intact CPE and hexanucleotide are both required to compete for the polyadenylation apparatus. Gel mobility shift assays show that two polyadenylation complexes are formed on B4 RNA. Optimal complex formation requires an intact CPE and hexanucleotide but not ongoing adenylation. These data, plus additional RNA competition studies, suggest that stable complex formation is enhanced by an interaction of the trans-acting factors that bind the CPE and polyadenylation hexanucleotide.

scholarly journals A Viral Genome Landscape of RNA Polyadenylation from KSHV Latent to Lytic Infection

2013 ◽  
Vol 9 (11) ◽  
pp. e1003749 ◽  
Author(s):  
Vladimir Majerciak ◽  
Ting Ni ◽  
Wenjing Yang ◽  
Bowen Meng ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Viral Genome ◽  
Lytic Infection ◽  
Rna Polyadenylation

scholarly journals Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR

RNA ◽  
2007 ◽  
Vol 13 (7) ◽  
pp. 1103-1115 ◽  
Author(s):  
T. Hall-Pogar ◽  
S. Liang ◽  
L. K. Hague ◽  
C. S. Lutz
Keyword(s):  
Cox 2 ◽  
Rna Polyadenylation

A classification-based prediction model of messenger RNA polyadenylation sites

2010 ◽  
Vol 265 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Guoli Ji ◽  
Xiaohui Wu ◽  
Yingjia Shen ◽  
Jiangyin Huang ◽  
Qingshun Quinn Li
Keyword(s):  
Prediction Model ◽  
Messenger Rna ◽  
Polyadenylation Sites ◽  
Rna Polyadenylation

Maturation-specific polyadenylation and translational control: diversity of cytoplasmic polyadenylation elements, influence of poly(A) tail size, and formation of stable polyadenylation complexes

1990 ◽  
Vol 10 (11) ◽  
pp. 5634-5645
Author(s):  
J Paris ◽  
J D Richter
Keyword(s):  
Complex Formation ◽  
Oocyte Maturation ◽  
Translational Control ◽  
Untranslated Regions ◽  
Stable Complex ◽  
Mobility Shift ◽  
Cytoplasmic Polyadenylation ◽  
Egg Extracts ◽  
Gel Mobility Shift ◽  
Rna Polyadenylation

Early embryonic development in Xenopus laevis is programmed in part by maternally derived mRNAs, many of which are translated at the completion of meiosis (oocyte maturation). Polysomal recruitment of at least one of these mRNAs, G10, is regulated by cytoplasmic poly(A) elongation which, in turn, is dependent upon the cytoplasmic polyadenylation element (CPE) UUUUUUAUAAAG and the hexanucleotide AAUAAA (L. L. McGrew, E. Dworkin-Rastl, M. B. Dworkin, and J. D. Richter, Genes Dev. 3:803-815, 1989). We have investigated whether sequences similar to the G10 RNA CPE that are present in other RNAs could also be responsible for maturation-specific polyadenylation. B4 RNA, which encodes a histone H1-like protein, requires a CPE of the sequence UUUUUAAU as well as the polyadenylation hexanucleotide. The 3' untranslated regions of Xenopus c-mos RNA and mouse HPRT RNA also contain U-rich CPEs since they confer maturation-specific polyadenylation when fused to Xenopus B-globin RNA. Polyadenylation of B4 RNA, which occurs very early during maturation, is limited to 150 residues, and it is this number that is required for polysomal recruitment. To investigate the possible diversity of factors and/or affinities that might control polyadenylation, egg extracts that faithfully adenylate exogenously added RNA were used in competition experiments. At least one factor is shared by B4 and G10 RNAs, although it has a much greater affinity for B4 RNA. Additional experiments demonstrate that an intact CPE and hexanucleotide are both required to compete for the polyadenylation apparatus. Gel mobility shift assays show that two polyadenylation complexes are formed on B4 RNA. Optimal complex formation requires an intact CPE and hexanucleotide but not ongoing adenylation. These data, plus additional RNA competition studies, suggest that stable complex formation is enhanced by an interaction of the trans-acting factors that bind the CPE and polyadenylation hexanucleotide.

scholarly journals Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice†

2019 ◽  
Vol 100 (6) ◽  
pp. 1673-1685 ◽  
Author(s):  
Chunwei Zheng ◽  
Ying-Chun Ouyang ◽  
Binjie Jiang ◽  
Xiwen Lin ◽  
Jian Chen ◽  
...  
Keyword(s):  
Sperm Head ◽  
Rna Polyadenylation

The post-transcriptional life of mammalian mitochondrial RNA

2012 ◽  
Vol 444 (3) ◽  
pp. 357-373 ◽  
Author(s):  
Joanna Rorbach ◽  
Michal Minczuk
Keyword(s):  
Messenger Rna ◽  
Mitochondrial Gene ◽  
Rna Stability ◽  
Stability Control ◽  
Mitochondrial Rna ◽  
Mammalian Mitochondria ◽  
Mitochondrial Ribosome ◽  
Rna Maturation ◽  
Rna Polyadenylation

Mammalian mitochondria contain their own genome that encodes mRNAs for thirteen essential subunits of the complexes performing oxidative phosporylation as well as the RNA components (two rRNAs and 22 tRNAs) needed for their translation in mitochondria. All RNA species are produced from single polycistronic precursor RNAs, yet the relative concentrations of various RNAs differ significantly. This underscores the essential role of post-transcriptional mechanisms that control the maturation, stability and translation of mitochondrial RNAs. The present review provides a detailed summary on the role of RNA maturation in the regulation of mitochondrial gene expression, focusing mainly on messenger RNA polyadenylation and stability control. Furthermore, the role of mitochondrial ribosomal RNA stability, processing and modifications in the biogenesis of the mitochondrial ribosome is discussed.

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