A method to construct the dynamic landscape of a bio-membrane with experiment and simulation

Biomolecular function is based on a complex hierarchy of molecular motions. While biophysical methods can reveal details of specific motions, a concept for the comprehensive description of molecular dynamics over a wide range of correlation times has been unattainable. Here, we report an approach to construct the dynamic landscape of biomolecules, which describes the aggregate influence of multiple motions acting on various timescales and on multiple positions in the molecule. To this end, we use 13C NMR relaxation and molecular dynamics simulation data for the characterization of fully hydrated palmitoyl-oleoyl-phosphatidylcholine bilayers. We combine dynamics detector methodology with a new frame analysis of motion that yields site-specific amplitudes of motion, separated both by type and timescale of motion. In this study, we show that this separation allows the detailed description of the dynamic landscape, which yields vast differences in motional amplitudes and correlation times depending on molecular position.

Insights Into the Changing Landscape of Coronavirus Disease 2019

Coronavirus disease 2019 (COVID-19) is a highly contagious, infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2019 in Wuhan China. A year after the World Health Organization declared COVID-19 a global pandemic, over 215 million confirmed cases and approximately 5 million deaths have been reported worldwide. In this multidisciplinary review, we summarize important insights for COVID-19, ranging from its origin, pathology, epidemiology, to clinical manifestations and treatment. More importantly, we also highlight the foundational connection between genetics and the development of personalized medicine and how these aspects have an impact on disease treatment and management in the dynamic landscape of this pandemic.

Hydrogeomorphology as a Tool in the Evolutionary Analysis of the Dynamic Landscape—Application to Larrodrigo, Salamanca, Spain

Evolutionary analysis of the fluvial landscape provides relevant inputs for the environmental management of a territory, in such a way that the understanding of the dynamics of fluvial spaces becomes a preponderant factor in the definition of protection and management strategies. Although the development of geographic information systems is a step forward in the study of the landscape, it is necessary to establish methodological frameworks that make remote sensing techniques available at multiple spatio-temporal scales, especially in basins with high levels of intervention. In the present study, we develop a methodology for the analysis of the fluvial landscape development in the last century of a highly modified water body, through the detailed study of hydrogeomorphic elements, using remote sensing techniques including high-density surface data (LiDAR) and historical aerial imageries; when supported by fieldwork, these allow for the identification of the sequence of sedimentation–erosion zones, differentiating in detail the zones denominated as areas of current erosion, accretion zones, and historical erosion zones. An application of the methodology was carried out in the Larrodrigo stream, located in Salamanca, Spain.

COVIDiSTRESS diverse dataset on psychological and behavioural outcomes one year into the COVID-19 pandemic

During the onset of the COVID-19 pandemic, the COVIDiSTRESS Consortium launched an open-access global survey to understand and improve individuals’ experiences related to the crisis. A year later, we extended this line of research by launching a new survey to address the dynamic landscape of the pandemic. This survey was released with the goal of addressing diversity, equity, and inclusion by working with over 150 researchers across the globe who collected data in 48 languages and dialects across 137 countries. The resulting cleaned dataset described here includes 15,740 of over 20,000 responses. The dataset allows cross-cultural study of psychological wellbeing and behaviours a year into the pandemic. It includes measures of stress, resilience, vaccine attitudes, trust in government and scientists, compliance, and information acquisition and misperceptions regarding COVID-19. Open-access raw and cleaned datasets with computed scores are available. Just as our initial COVIDiSTRESS dataset has facilitated government policy decisions regarding health crises, this dataset can be used by researchers and policy makers to inform research, decisions, and policy.

Songlines: Preserving cultural heritage through architecture

<p>In indigenous Australian culture, the ‘Songlines’ represent the routes across the landscape followed by the original ‘creator-beings’ of the ‘Dreaming’. The ‘Songlines’ describe the locations of mountains, waterholes, ravines, and other landscape features that were ‘created’ by the movements and interactions of the creator-beings. Throughout Australia’s vast history, the indigenous peoples have recited the Songlines as oral narratives for the next generation, while also using the Songlines to navigate across vast tracts of wilderness. But with the departure of a disenfranchised younger generation of indigenous Australians to cities and government settlements, the Songlines are at risk of being forgotten. Songlines are not merely navigation devices. They act as mnemonics that define cultural values, indigenous laws and ancestral heritage. Stories of the ‘Dreaming’ acknowledge the past, present and future. As such, they are capable of re-engaging Indigenous Australians with a sense of place, heritage,and values, that are so menaingful to there culture and religion. The sites for this design-led investigation are located in Arkaroola Sanctuary, Vulkanatha /Gammon Ranges and Ikara-Flinders Ranges - located in South Australia. This vast expanse of land is associated with the indigenous people known as the Adnyamathanha. The principal aim of this investigation is to conceive a series of collaborative architectural shelters that are designed and positioned in ways that can help reawaken, expose, and define characteristics of ‘Songlines’ for future generations. The architecture will act as a reminder of cultural values, while serving as a framing device to reveal the dynamic landscape features that form the Adnyamathanha’s traditional Songlines. This is to safeguard knowledge, and re-awaken awareness of ‘Songlines’ for younger indigenous peoples who have left their homeland and tribal region. The architectural shelters, as points of pause along the Songlines, act as mnemonic devices that help keep alive a vibrant and fundamental sense of cultural identity and place. The architectural interventions seek to diffuse boundaries between Indigenous and Non-Indigenous cultures – given the current integrated context of Australia.</p>

Songlines: Preserving cultural heritage through architecture

<p>In indigenous Australian culture, the ‘Songlines’ represent the routes across the landscape followed by the original ‘creator-beings’ of the ‘Dreaming’. The ‘Songlines’ describe the locations of mountains, waterholes, ravines, and other landscape features that were ‘created’ by the movements and interactions of the creator-beings. Throughout Australia’s vast history, the indigenous peoples have recited the Songlines as oral narratives for the next generation, while also using the Songlines to navigate across vast tracts of wilderness. But with the departure of a disenfranchised younger generation of indigenous Australians to cities and government settlements, the Songlines are at risk of being forgotten. Songlines are not merely navigation devices. They act as mnemonics that define cultural values, indigenous laws and ancestral heritage. Stories of the ‘Dreaming’ acknowledge the past, present and future. As such, they are capable of re-engaging Indigenous Australians with a sense of place, heritage,and values, that are so menaingful to there culture and religion. The sites for this design-led investigation are located in Arkaroola Sanctuary, Vulkanatha /Gammon Ranges and Ikara-Flinders Ranges - located in South Australia. This vast expanse of land is associated with the indigenous people known as the Adnyamathanha. The principal aim of this investigation is to conceive a series of collaborative architectural shelters that are designed and positioned in ways that can help reawaken, expose, and define characteristics of ‘Songlines’ for future generations. The architecture will act as a reminder of cultural values, while serving as a framing device to reveal the dynamic landscape features that form the Adnyamathanha’s traditional Songlines. This is to safeguard knowledge, and re-awaken awareness of ‘Songlines’ for younger indigenous peoples who have left their homeland and tribal region. The architectural shelters, as points of pause along the Songlines, act as mnemonic devices that help keep alive a vibrant and fundamental sense of cultural identity and place. The architectural interventions seek to diffuse boundaries between Indigenous and Non-Indigenous cultures – given the current integrated context of Australia.</p>

Analysis of the Dynamic Landscape of Scientific Innovation in the Chip Domain

Chip is the core of the electronic information industry, and its current &quot;neck&quot; phenomenon is rooted in the failure to keep up with basic research. This study aims to provide a clear landscape of the dynamics of scientific innovation in the chip domain. Specifically, this study uses bibliometrics, social network analysis, and SPLC algorithm-based master path analysis to analyze spatial and temporal trends, collaboration characteristics, knowledge flows, and mainstream research paths through the global output of scientific paper in the field of the chip. The results show that the scientific output in this field has grown significantly, the network size is expanding, a few countries/regions and organizations are in the main position of chip science innovation, and the research themes on the mainstream research paths are concentrated in chip manufacturing. The study can provide lessons for researchers, policymakers, and research funders.