scholarly journals Glandular Stomach

2020 ◽  
Author(s):  
Keyword(s):  
Glandular Stomach

Genotoxicity and Cell Proliferative Activity of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone [MX] in Rat Glandular Stomach

1992 ◽  
Vol 25 (11) ◽  
pp. 341-345 ◽  
Author(s):  
C. Furihata ◽  
M. Yamashita ◽  
N. Kinae ◽  
T. Matsushima
Keyword(s):  
Cell Proliferation ◽  
Body Weight ◽  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Tap Water ◽  
Fold Increase ◽  
Single Strand ◽  
Glandular Stomach ◽  
Decarboxylase Activity ◽  
Pyloric Mucosa

MX is a strong direct acting mutagen on Salmonella typhimurium TA100 and is present in chlorinated tap water which contains organic compounds. MX was administered orally to 7-week-old male F344 rats, and its geno-toxicity in the pyloric mucosa of stomach was examined by analysis of DNA single strand scissions by the alkaline elution method. The effect of MX on cell proliferation was examined by assays of the inductions of replicative DNA synthesis and ornithine decarboxylase. MX at closes of 20-48 mg/kg body weight induced DNA single strand scissions dose-dependently (p<0.02) in the pyloric mucosa of the stomach 2 h after its administration. Moreover at doses of 10-60 mg/kg body weight, it induced up to 21-fold increase in replicative DNA synthesis (p<0.01) 16 h after its administration. At doses of 10-60 mg/kg body weight, it induced up to 100-fold increase in ornithine decarboxylase activity with a maximum 16 h after its administration. These results suggest that MX is genotoxic and induces cell proliferation in the glandular stomach of rats.

scholarly journals THE EFFECT OF 2: 2-DIPHENYL-4-N-HEXAMETHYLEN IMINO BUTYRAMIDE METHIODIDE ON EXPERIMENTAL CHRONIC ULCER IN GLANDULAR STOMACH OF RATS

1971 ◽  
Vol 21 (2) ◽  
pp. 139-154
Author(s):  
Takashi HISAMATSU ◽  
Tadashi NAKAZAWA ◽  
Takemi KOEDA
Keyword(s):  
Chronic Ulcer ◽  
Glandular Stomach

Possible Antitumor Promoter in the Glandular Stomach: Calcium Chloride

1990 ◽  
pp. 395-400
Author(s):  
C. Furihata ◽  
T. Matsushima
Keyword(s):  
Calcium Chloride ◽  
Glandular Stomach

SEQUENTIAL MORPHOLOGICAL CHANGES OF ULCERATION IN THE GLANDULAR STOMACH OF RATS INDUCED BY IODOACETAMIDE

1975 ◽  
Vol 25 (4) ◽  
pp. 463-476
Author(s):  
Tomoyuki Shirai ◽  
Michihito Takahashi ◽  
Shoji Fukushima ◽  
Masae Tatematsu ◽  
Motoo Hananouchi ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Glandular Stomach

The Combined Effect of 3-Methylcholanthrene and N,N′-2,7-fluorenylenebisacetamide on the Induction of Cancer of the Glandular Stomach of the Rat

1965 ◽  
Vol 34 (2) ◽  
pp. 157-174 ◽  
Author(s):  
Harold L. Stewart ◽  
Katharine C. Snell ◽  
Harold P. Morris
Keyword(s):  
Combined Effect ◽  
Glandular Stomach

DNA damaging and cell proliferative activity of 1-methyl-1-nitrosourea in rat glandular stomach mucosa

1995 ◽  
Vol 348 (4) ◽  
pp. 169-173 ◽  
Author(s):  
Chie Furihata ◽  
Emi Ikui ◽  
Taijiro Matsushima
Keyword(s):  
Proliferative Activity ◽  
Glandular Stomach ◽  
Stomach Mucosa ◽  
Cell Proliferative Activity
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