scholarly journals Right Lung Alveolus

2020 ◽  
Author(s):  
Keyword(s):  
Lung Alveolus

scholarly journals From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 “Basic and Translational Science.”

2019 ◽  
Vol 5 (2) ◽  
pp. 00194-2018 ◽  
Author(s):  
Marko Z. Nikolić ◽  
Eva M. Garrido-Martin ◽  
Flavia R. Greiffo ◽  
Aurélie Fabre ◽  
Irene H. Heijink ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Human Lung ◽  
Basic Research ◽  
Clinical Findings ◽  
Translational Science ◽  
European Respiratory Society ◽  
Lung Alveolus ◽  
Epigenetic Editing ◽  
Selection Of ◽  
Novel Therapeutic

The European Respiratory Society (ERS) International Congress is the largest respiratory congress and brings together leading experts in all fields of respiratory medicine and research. ERS Assembly 3 shapes the basic and translational science aspects of this congress, aiming to combine cutting-edge novel developments in basic research with novel clinical findings. In this article, we summarise a selection of the scientific highlights from the perspective of the three groups within Assembly 3. In particular, we discuss new insights into the pathophysiology of the human alveolus, novel tools in organoid development and (epi)genome editing, as well as insights from the presented abstracts on novel therapeutic targets being identified for idiopathic pulmonary fibrosis.

scholarly journals Advanced Microengineered Lung Models for Translational Drug Discovery

2018 ◽  
Vol 23 (8) ◽  
pp. 777-789 ◽  
Author(s):  
Brian F. Niemeyer ◽  
Peng Zhao ◽  
Rubin M. Tuder ◽  
Kambez H. Benam
Keyword(s):  
Biomarker Discovery ◽  
Human Lung ◽  
In Vivo Models ◽  
Chip Technology ◽  
Preclinical Drug Development ◽  
Lung Alveolus ◽  
Organ Level ◽  
On Chip

Lung diseases impose a significant socioeconomic burden and are a leading cause of morbidity and mortality worldwide. Moreover, respiratory medicine, unlike several other therapeutic areas, faces a disappointingly low number of new approved therapies. This is partly due to lack of reliable in vitro or in vivo models that can reproduce organ-level complexity and pathophysiological responses of human lung. Here, we examine new opportunities in application of recently emerged organ-on-chip technology to model human lung alveolus and small airway in preclinical drug development and biomarker discovery. We also discuss challenges that need to be addressed in coming years to further enhance the physiological and clinical relevance of these microsystems, enable their increased accessibility, and support their leap into personalized medicine.

scholarly journals Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

Nature ◽  
2018 ◽  
Vol 555 (7695) ◽  
pp. 251-255 ◽  
Author(s):  
William J. Zacharias ◽  
David B. Frank ◽  
Jarod A. Zepp ◽  
Michael P. Morley ◽  
Farrah A. Alkhaleel ◽  
...  
Keyword(s):  
Evolutionarily Conserved ◽  
Lung Alveolus

scholarly journals Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

2017 ◽  
Vol 103 (2) ◽  
pp. 332-340 ◽  
Author(s):  
A Jain ◽  
R Barrile ◽  
AD van der Meer ◽  
A Mammoto ◽  
T Mammoto ◽  
...  
Keyword(s):  
Human Lung ◽  
Intravascular Thrombosis ◽  
Lung Alveolus

Dynamics of Rapid Spore Capture by Dendritic Cells in the Lung Alveolus

2012 ◽  
Vol 186 (2) ◽  
pp. e2-e3 ◽  
Author(s):  
Daniel Fiole ◽  
Julien Douady ◽  
Jean-Claude Vial ◽  
Anne Quesnel-Hellmann ◽  
Jean-Nicolas Tournier
Keyword(s):  
Dendritic Cells ◽  
Lung Alveolus

Analysis of elastic and surface tension effects in the lung alveolus using finite element methods

1986 ◽  
Vol 19 (7) ◽  
pp. 541-549 ◽  
Author(s):  
R. Kowe ◽  
R.C. Schroter ◽  
F.L. Matthews ◽  
D. Hitchings
Keyword(s):  
Surface Tension ◽  
Finite Element ◽  
Finite Element Methods ◽  
Lung Alveolus

scholarly journals Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review

2014 ◽  
Vol 8 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Najla Fiaturi ◽  
John J. Castellot ◽  
Heber C. Nielsen
Keyword(s):  
Lung Alveolus

Compartmentalization of 11-oxidoreductase within fetal lung alveolus

1985 ◽  
Vol 249 (1) ◽  
pp. C173-C176 ◽  
Author(s):  
J. S. Torday ◽  
M. Post ◽  
B. T. Smith
Keyword(s):  
Lung Surfactant ◽  
Fetal Lung ◽  
Alveolar Type ◽  
Oxidoreductase Activity ◽  
Alveolar Type Ii Cell ◽  
Factor Production ◽  
Fetal Rat ◽  
Surfactant Production ◽  
Type Ii Cell ◽  
Lung Alveolus

The role of 11-oxidoreductase in the cellular process of fetal lung surfactant production and its localization within the alveolar domain have been investigated. In organotypic cultures of fetal rat lung, cortisol and cortisone markedly stimulate saturated phosphatidylcholine synthesis by the alveolar type II cell; a 10-fold excess of 11-ketoprogesterone blocks the bioactivity of cortisone. Both cortisol and cortisone also stimulate fibroblast-pneumonocyte factor production, whereas 11-ketoprogesterone blocks the effect of cortisone, but not of cortisol, suggesting that cortisone stimulation of fibroblast-pneumonocyte factor production depends on its conversion to cortisol by 11-oxidoreductase. A survey of the cells that are present in the alveolar domain revealed that 11-oxidoreductase activity is only present in the fibroblast. Localization of both 11-oxidoreductase and fibroblast-pneumonocyte factor production within the same cell emphasizes the significance of 11-oxidoreductase in the regulation of fetal lung surfactant production.

scholarly journals The reconstruction of lung alveolus-like structure in collagen-matrigel/microcapsules scaffolds in vitro

2011 ◽  
Vol 15 (9) ◽  
pp. 1878-1886 ◽  
Author(s):  
Wen-Jun Zhang ◽  
Qiu-Xia Lin ◽  
Ye Zhang ◽  
Chang-Ting Liu ◽  
Li-Yuan Qiu ◽  
...  
Keyword(s):  
Lung Alveolus
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